Results 71 to 80 of about 128,236 (338)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Immersive Multiplayer VR: Unreal Engine’s Strengths, Limitations, and Future Prospects

open access: yesIEEE Access
Virtual Reality (VR) has revolutionized digital interactions, particularly in multiplayer games, where players engage in immersive experiences that foster social connectivity and collaboration.
Santiago Berrezueta-Guzman   +1 more
doaj   +1 more source

Edge Computing Resource Allocation for Dynamic Networks: The DRUID-NET Vision and Perspective

open access: yesSensors, 2020
The potential offered by the abundance of sensors, actuators, and communications in the Internet of Things (IoT) era is hindered by the limited computational capacity of local nodes.
Dimitrios Dechouniotis   +5 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Digital Twin in Industries: A Comprehensive Survey

open access: yesIEEE Access
Industrial networks are undergoing rapid transformation driven by the convergence of emerging technologies that are revolutionizing conventional workflows, enhancing operational efficiency, and fundamentally redefining the industrial landscape across ...
Md Bokhtiar Al Zami   +3 more
doaj   +1 more source

Bridging: Locating critical connectors in a network [PDF]

open access: yesSocial Networks, 2010
This paper proposes several measures for bridging in networks derived from Granovetter's (1973) insight that links which reduce distances in a network are important structural bridges. Bridging is calculated by systematically deleting links and calculating the resultant changes in network cohesion (measured as the inverse average path length).
Thomas W, Valente, Kayo, Fujimoto
openaire   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Improving Primary Healthcare Access for Asylum Seekers and Refugees: A Qualitative Study From a Swiss Family Physician Perspective

open access: yesJournal of Primary Care & Community Health, 2023
Since 2015 the need for evidence-based guidance in primary health care management of refugees, asylum seekers, and immigrants has dramatically increased. The aims of this study were to identify the challenges met by primary care physicians in Switzerland,
Johanna Oehri   +4 more
doaj   +1 more source

Toward an efficient solution for dynamic ad hoc network interoperability [PDF]

open access: yes, 2002
An ad hoc network is formed by an impromptu grouping of network capable nodes. The nodes forming the network have unconstrained mobility, and so provide a dynamic network topology.
Prince, Daniel   +2 more
core  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

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