Results 81 to 90 of about 529,068 (299)

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Proposing, Validating and Analyzing the Functional Model for Innovation Intermediaries: Case Study of Iranian Science and Technology Parks [PDF]

بهبود مدیریت
Intermediary organizations are amongst key players in the national innovation system which facilitate the process of innovation in various fields by carrying out various functions and coordinate interactions between different actors of this system ...
Zahra Mohammadhashemi, Safora Allahy, Fahimeh Mohammadzamani   +2 more
doaj   +1 more source

Bayesian Network-based model for bridge network management

, 2015
Maintenance for highway bridges is crucial in order to keep the network in a satisfactory condi-tion for users but is also a costly affair. This paper proposes a dynamic, Bayesian network-based model to provide cost-efficient strategies in the context of bridge network management.
Kosgodagan-Dalla Torre, Alex, Morales-Nápoles, Oswaldo, Maljaars, Johan, Castanier, Bruno, Yeung, Thomas   +4 more
openaire   +4 more sources

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Mentoring Cybersecurity Students in Online Degree Programs

Journal of the Colloquium for Information Systems Security Education
This paper examines the design, implementation, and continuous improvement of a successful mentoring program integrated into cybersecurity capstone courses at Kennesaw State University, aimed at bridging the gap between academic learning and real-world ...
Herbert Mattord, Michael Whitman
doaj   +1 more source

Oxamate and Chloranilate Bridges in Polymeric Networks

Phosphorus, Sulfur, and Silicon and the Related Elements, 1997
Abstract: Oxamic acid acts as a bridging ligand with lanthanide ions to form, for example 9-coordinate Ho(III) systems in which the holmium centres are linked into sheets via H-bonds. Nd(III) also forms 9-coordinate complexes with oxamate but an alternative packing motif is observed.
Veltsistas, P., Papadimitriou, C., Arabatzis, Y., Slawin, A. M. Z., Woollins, J. D.   +4 more
openaire   +2 more sources

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Educational Leadership Based on Social Capital for Improving Quality of Private Secondary School

Jurnal Pendidikan Islam, 2017
This study aims to explain the leadership pattern of social capital based education for the quality improvement of private schools. The research is conducted at private Junior Secondary Level with a qualitative naturalistic approach.
Suwadi
doaj   +1 more source