Results 101 to 110 of about 6,939 (185)

3D Bioprinted Glioblastoma Multiforme Models: How the Extracellular Matrix Glycosignature Influences Drug Response

Advanced Functional Materials, EarlyView.
Aberrant glycosylation in the glioblastoma tumor microenvironment drives therapeutic resistance. Here, a 3D bioprinted model was engineered by incorporating α‐NeuNAc‐(2→3)‐β‐D‐Gal‐ and chondroitin sulfate. Combined multiplex immunofluorescence and synchrotron‐based nanoCT analysis revealed that glycan‐matrix interactions dictate specific drug‐escape ...
Francesca Cadamuro, Marco Piazzoni, Ilaria Borghi, Alberto Baeri, Alessandro Fumagalli, Federica Perillo, Hafiz Muhammad Fahad, Martina Ghizzi, Luca Crippa, Gabriella Nicolini, Angela Bentivegna, Daniele Ramazzotti, Valentina Zuliani, Mirko Rivara, Carlo Giorgio Giussani, Andrea Di Cristofori, Guido Cavaletti, Federica Facciotti, Sobhan Sheikhi, Claire Seydoux, Murielle Salome, Peter Cloetens, Alberto Bravin, Paola Coan, Francesco Nicotra, Laura Russo   +25 more
wiley   +1 more source

Polyfunctional T peripheral helper cells are associated with the magnitude and durability of antibody responses after COVID-19. [PDF]

Clin Transl Immunology
Tungatt K, Gomes GMC, Fewings NL, Stubis A, Doyle CM, Merheb V, Aggarwal A, Byth K, Robertson H, Dervish S, Maddocks S, Taylor J, Bull RA, Martinello M, COSIN Protocol Steering Committee, Brilot F, Turville SG, Cunningham AL, Sandgren KJ.   +18 more
europepmc   +1 more source

Dual‐Layer Conducting and Redox Polymer Bioanodes for Synergistic Enhancement of Microbial Extracellular Electron Transfer

Advanced Functional Materials, EarlyView.
A hybrid PEDOT/Fc‐LPEI conducting/redox polymer bioanode synergistically improves microbial extracellular electron transfer (EET) in Shewanella oneidensis MR‐1. The dual‐layer interface delivers 18‐fold higher current output and 27‐fold greater charge collected than bare carbon felt, highlighting an effective strategy for high‐performance ...
Shenghan Gu, Saman Azhari, Kuniaki Nagamine, Takeo Miyake, Gábor Méhes   +4 more
wiley   +1 more source

Feasibility of Smartphone-Derived Short-Interval Walking Tests for Monitoring Functional Recovery After Spine Surgery. [PDF]

JOR Spine
Puhakka J, Jung M, Fekete T, Loibl M, Kleinstück F, Porchet F, Ropelato M, Gocevic M, Galbusera F, Cina A, O'Riordan D, Kosola J, Haschtmann D.   +12 more
europepmc   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

Dengue fever maculopathy: case report and brief review. [PDF]

GMS Ophthalmol Cases
Gameiro Filho AR, Odorcik WG, Garcia MHR, Novello MB, da Costa DS.   +4 more
europepmc   +1 more source

A Systematic Study of GelMA‐Carbopol Bioinks for High‐Fidelity Extrusion 3D Bioprinting at Physiological Temperatures

Advanced Healthcare Materials, EarlyView.
Gonzalez Martinez and collaborators develop a strategy to formulate high performance GelMA‐based bioinks with low solids contents. The resulting bioinks enable 3D bioprinting at 37 °C of high‐fidelity structures with tunable mechanical properties that support high cell viability and function.
David A. González‐Martínez, Aidee V. Arizpe Tafoya, Eduardo González‐Martínez, Mabel Barreiro Carpio, Laura Daniela Serrano Andrade, Christopher T. N. Chow, Mohammadhossein Dabaghi, Jeremy A. Hirota, Jose M. Moran‐Mirabal   +8 more
wiley   +1 more source

S100A8/9-NLRP3-mediated chronic unresolved inflammation drives cardiac pathologies following invasive pneumococcal disease. [PDF]

Exp Mol Med
Tousif S, Minassian D, He C, Singh B, Umbarkar P, Bhati AS, Mohasin M, Erdmann N, Xie M, Sethu P, Orihuela CJ, Lal H.   +11 more
europepmc   +1 more source

Sodium Alginate‐Based Submucosal Lifting Hydrogel for Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection

Advanced Healthcare Materials, EarlyView.
A biocompatible sodium alginate‐based hydrogel is developed as a next‐generation submucosal lifting agent intended for EMR and ESD. The optimized formulation exhibits a composition devoid of endotoxins, high viscosity, demonstrates reliable injectability, and ensures prolonged mucosal elevation.
Iram Maqsood, Venkata S. Akshintala, Surya T. Evani, Rebecca A. Krimins, Yihan Wang, Keith Freel, Ahmed Ibrahim, Saowanee Ngamruengphong, Mouen Khashab, Stephen W. Hoag   +9 more
wiley   +1 more source