Results 111 to 120 of about 6,869 (176)

S100A8/9-NLRP3-mediated chronic unresolved inflammation drives cardiac pathologies following invasive pneumococcal disease. [PDF]

Exp Mol Med
Tousif S, Minassian D, He C, Singh B, Umbarkar P, Bhati AS, Mohasin M, Erdmann N, Xie M, Sethu P, Orihuela CJ, Lal H.   +11 more
europepmc   +1 more source

Prostate Cancer Patient‐Derived Organoids (PDOs) as Functional Avatars for Antisense Oligonucleotide (ASO)‐Based Personalized Therapy

Advanced Healthcare Materials, EarlyView.
Prostate patient‐derived organoids (PDOs) were established from TURP and biopsy specimens with >90% success and retain key features of their tissues of origin, making them functional avatars for antisense oligonucleotide (ASO) therapy . Transfecting single cells outside the Matrigel matrix and then reconstituting organoids overcomes the 3D delivery ...
Thi Thom Tran, Thi Tu Uyen Phan, Michael Baboudjian, Quang Hieu Duong, Ines Sousa, Thi Thuy Le, Virginie Baylot, Sophie Giusiano, Laurent Daniel, Pauline Brige, Benjamin Guillet, Cyrille Bastide, Carmen Garrido, David Taïeb, Thi Khanh Le, Palma Rocchi   +15 more
wiley   +1 more source

Preclinical evaluation of AGT mRNA replacement therapy for primary hyperoxaluria type I disease. [PDF]

Sci Adv
Yang T, Ge J, Huang L, Zhu X, Zhang D, Tang S, Zhao J, Ma Y, Long M, Bo X, Li J, Zhang Y, Yuan Q, Sharma AD, Ott M, Geng H, Zhao Y, Zhang L, Shen H, Li H, Li D, Wan P, Xia Q.   +22 more
europepmc   +1 more source

Spatially Controlled Embedded Bioprinting of Prevascularized Spheroids‐Containing Biopatch Enables Functional Skin Regeneration

Advanced Healthcare Materials, EarlyView.
A spatially controlled embedded bioprinting strategy enables precise engineering of prevascularized multicellular spheroids within skin‐derived dECM bioinks. Optimized spheroid size, composition, and spacing promote vascular maturation, paracrine signaling, and tissue integration, resulting in enhanced angiogenesis, blood perfusion, and functional skin
Minjun Ahn, Gyu Tae Park, Dongjun Lee, Sik Yoon, Sae‐Ock Oh, Jae Ho Kim, Byoung Soo Kim   +6 more
wiley   +1 more source

Single-Cell and Plasma Proteomics Do Not Differentiate Patients With and Without SARS-CoV-2 Antigenemia in Convalescence in a Cohort of 100 Patients. [PDF]

Open Forum Infect Dis
Pienkos S, Swank Z, Hamlin RE, Rao M, Grant P, Bonilla H, Jacobson K, Jagannathan P, Singh U, Walt DR, Subramanian A, Blish C.   +11 more
europepmc   +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

Detected residual venous thrombi and catheter-directed management of intermediate-risk pulmonary thromboembolism. [PDF]

Front Cardiovasc Med
Heyman SN, Leibowitz D, Herzog E.
europepmc   +1 more source

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

Advanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park, Su Yong Kim, MinSu Jeong, Beom Joon Kim, Shin Hyuk Kang, Won‐Gun Koh   +5 more
wiley   +1 more source

Testosterone and androgen receptor pathway modulation in sepsis: immunometabolic mechanisms and therapeutic implications - a scoping review. [PDF]

Front Endocrinol (Lausanne)
Szczupak M, Kobak J, Kreczko M, Wierzchowska J, Krupa-Nurcek S.   +4 more
europepmc   +1 more source