Results 71 to 80 of about 46,748 (286)

Changes in brain-derived neurotrophic factors in schizophrenic patients with spiritual psychoreligious therapy

Journal of the Pakistan Medical Association
Objective: To examine the effect of Spiritual Quranic Emotional Freedom Technique therapy on the level of brain-derived neurotrophic factor in schizophrenic patients.
Lilin Rosyanti, Indriono Hadi, Akhmad, Teguh Faturrahman, Arip Hidayat   +4 more
doaj   +1 more source

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression

Advanced Science, EarlyView.
This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai, Taipeng Sun, Mengzhen Feng, Gang Chen, Junchi Zhou, Hong Zhuang, Dan Wang, Ying Chen, Zhen Cheng, Zhi Xu, Xiao Zheng, Xueli Zhang, Yonggui Yuan   +12 more
wiley   +1 more source

Intensive Case Management-based Treatment Program for Patients with Methamphetamine Use Disorder: A 12-month Follow-up Study

Taiwanese Journal of Psychiatry
Objective: Methamphetamine use disorder (MUD) is a global public health concern. While case management programs are used for treating substance use disorders, evidence of their efficacy remains limited.
Chun Lin, Su-Chen Fang, Yi-Chia Wu, Hu-Ming Chang, Shuang Chen, Ming-Chyi Huang   +5 more
doaj   +1 more source

MANAGEMENT OF THE PSEUDOBULBAR AFFECT (PBA) IN KABUKI SYNDROME COMBINED DEXTROMETHORPHAN-FLUOXETINE TREATMENT AS AN ALTERNATIVE TO DEXTROMETHORPHAN/QUINIDINE

Clinical and Biomedical Research, 2021
A case report of a patient with pseudo bulbar affect previous treatments included haloperidol (10mg), Inosina pranobex (600mg), clozapine (600mg), olanzapine (20mg), carbamazepine (200mg), paroxetine (20mg), phenobarbital (100mg) and topiramate (50mg ...
Victor Hugo Cordova, André Goldani, Paulo Belmonte-de-Abreu   +2 more
doaj  

Prevalence of psychiatric comorbidity among patients of type 2 diabetes mellitus in a hilly state of North India

Indian Journal of Endocrinology and Metabolism, 2019
Background: Psychiatric comorbidity with diabetes mellitus is common. Comorbidity of diabetes and psychiatric disorders can present in different patterns, which are associated with impaired quality of life, increased cost of care, poor treatment ...
Neeraj Kanwar, Ravi C Sharma, Dinesh D Sharma, Ramesh, Kiran Mokta, Jatinder K Mokta   +5 more
doaj   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Establishing the cut-off scores for the severity ranges of schizophrenia on the BPRS-6 scale: findings from the REAP-AP

Psychiatry and Clinical Psychopharmacology, 2019
Objective: Using data from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics (REAP-AP), our study aimed to establish the remission and severity ranges (mild, moderate, and severe) of schizophrenia on the Brief Psychiatric Rating
Seon-Cheol Park, Eun Young Jang, Kiwon Kim, Hoseon Lee, Joonho Choi, Amitava Dan, Arshad Hussain, Andi Jayalangkara Tanra, Takahiro A. Kato, Kok Yoon Chee, Sih-Ku Lin, Chay Hoon Tan, Afzal Javed, Norman Sartorius, Naotaka Shinfuku, Yong Chon Park   +15 more
doaj   +1 more source

Evaluaton of regional cerebral blood flow alterations by limbic activation in patients with schizophrenia

Medicine Science, 2018
The aim of study is to evaluate the functions of limbic system in schizophrenia by performing procaine administration and using single photon emission computed tomography (SPECT). 22 patients and 19 controls were included in the study.
Ikbal Inanli, Ibrahim Eren, Harun Suslu, Mustafa Yildiz   +3 more
doaj   +1 more source

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source