Results 41 to 50 of about 29,250 (249)

First Synoptic Observations of Geomagnetic Storm Effects on the Global‐Scale OI 135.6‐nm Dayglow in the Thermosphere by the GOLD Mission

open access: yesGeophysical Research Letters, 2020
The Global‐scale Observations of the Limb and Disk (GOLD) mission provides, for the first time, a synoptic view of the thermospheric response to a moderate geomagnetic storm at a 30‐min cadence.
Quan Gan   +8 more
doaj   +1 more source

Preatmospheric Detection of a Meter-sized Earth Impactor

open access: yesThe Planetary Science Journal, 2023
On 2020 September 18 U.S. Government (USG) sensors detected a bolide with peak bolometric magnitude of −19 over the Western Pacific. The impact was also detected by the Geostationary Lightning Mapper instrument on the GOES-17 satellite and infrasound ...
David L. Clark   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Thermionic emission in gold nanoparticles under femtosecond laser irradiation observed with photoemission electron microscopy

open access: yesAIP Advances, 2019
This study reports that thermionic emission can dominate over multi-photon ionization in gold nanoparticles under femtosecond laser irradiation. The brightness of individual particles observed with photoemission electron microscopy increased steeply for ...
Bochao Li   +5 more
doaj   +1 more source

A Neurocomputational Account of the Role of Contour Facilitation in Brightness Perception

open access: yesFrontiers in Human Neuroscience, 2015
A novel filling-in model is proposed in order to account for challenging brightness illusions where inducing background elements are spatially separated from gray target such as dungeon, cube and grating illusion, bull's eye and ring patterns.
Dražen eDomijan
doaj   +1 more source

Approaching the Tsirelson bound with a Sagnac source of polarization-entangled photons

open access: yesSciPost Physics, 2021
High-fidelity polarization-entangled photons are a powerful resource for quantum communication, distributing entanglement and quantum teleportation. The Bell-CHSH inequality $S\leq2$ is violated by bipartite entanglement and only maximally entangled ...
Sandra Meraner, Robert J. Chapman, Stefan Frick, Robert Keil, Maximilian Prilmüller, Gregor Weihs
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

THE MEAN LIGHT CURVES OF THE MIRA-TYPE STARS IN THE H- AND K-BANDS

open access: yesOdessa Astronomical Publications, 2016
. For nine Mira-type stars (o Cet, R Leo, S Car, U Her, X Oph, R Aql, RR Aql, S Ori, S Scl,) and one semi-regular star (L2 Pup), the mean light curves have been obtained.
L. S. Kudashkina
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

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