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Protocol to investigate G protein-coupled receptor signaling kinetics and concentration-dependent responses using ONE-GO biosensors. [PDF]
STAR ProtocJanicot R, Garcia-Marcos M.
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Near Add Power of Glaucoma Patients with Early Presbyopia. [PDF]
J Clin MedAyaki M, Ichikawa K.
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Melanin-Binding-Based Discovery of Topically Instilled Carbonic Anhydrase Inhibitors for Targeted Delivery and Prolonged Action in the Eye. [PDF]
Mol PharmValtari A +11 more
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Brimonidine is a highly selective 2-adrenoceptor agonist that lowers intraocular pressure (IOP) by decreasing aqueous humor production and increasing aqueous humor outflow via the uveoscleral route. Brimonidine is used to treat glaucoma and other eye conditions.
Ahmed H, Bakheit +3 more
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Brimonidine is a highly selective 2-adrenoceptor agonist that lowers intraocular pressure (IOP) by decreasing aqueous humor production and increasing aqueous humor outflow via the uveoscleral route. Brimonidine is used to treat glaucoma and other eye conditions.
Ahmed H, Bakheit +3 more
openaire +2 more sources
Expert Opinion on Investigational Drugs, 1997
Brimonidine tartrate is a highly selective alpha2-adrenergic receptor agonist indicated for the chronic treatment of glaucoma and ocular hypertension. Glaucoma, a serious worldwide public health problem causing blindness in 5.2 million people, is treated by drugs that lower the intraocular pressure (IOP), a primary risk factor in glaucomatous optic ...
L. B. Cantor, J. Burke
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Brimonidine tartrate is a highly selective alpha2-adrenergic receptor agonist indicated for the chronic treatment of glaucoma and ocular hypertension. Glaucoma, a serious worldwide public health problem causing blindness in 5.2 million people, is treated by drugs that lower the intraocular pressure (IOP), a primary risk factor in glaucomatous optic ...
L. B. Cantor, J. Burke
openaire +6 more sources
Expert Opinion on Drug Safety, 2010
Brimonidine is a drug used in the management of glaucoma throughout the world and is the most modern alpha(2)-adrenoceptor agonist available. This review comprehensively discusses the use of brimonidine for glaucoma.A historical insight into the development of selective adrenergic glaucoma drugs is given, followed by a description of the mechanisms of ...
Mamun Q. Rahman +2 more
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Brimonidine is a drug used in the management of glaucoma throughout the world and is the most modern alpha(2)-adrenoceptor agonist available. This review comprehensively discusses the use of brimonidine for glaucoma.A historical insight into the development of selective adrenergic glaucoma drugs is given, followed by a description of the mechanisms of ...
Mamun Q. Rahman +2 more
openaire +2 more sources
Preclinical evaluation of brimonidine
Survey of Ophthalmology, 1996Preclinical studies of brimonidine show that it is a potent alpha 2-adrenoceptor agonist that is 1000-fold more selective for the alpha 2-vs. the alpha 1-adrenoceptor, and is 7-12-fold more alpha 2-selective than clonidine and 23- to 32-fold more alpha 2-selective than apraclonidine (p-aminoclonidine).
James A. Burke, Michal Schwartz
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Brimonidine Induced Anterior Uveitis
Ocular Immunology and Inflammation, 2015To present the largest series reported so far of brimonidine induced granulomatous anterior uveitis.Retrospective chart review of patients with chronic glaucoma on treatment with brimonidine presenting with anterior uveitis.19 eyes of 12 patients with chronic glaucoma developed anterior uveitis with granulomatous keratic precipitates after being ...
Ehud Zamir, Jacqueline Beltz
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Preclinical Safety Profile of Brimonidine
European Journal of Ophthalmology, 1996Brimonidine is a selective α2-adrenergic agonist developed for lowering intraocular pressure in glaucoma patients. Since brimonidine will be used in long-term theraphy, the safety of this drug is an important feature for its clinical success. Brimonidine has been evaluated in a number of safety studies using doses much greater than those in humans. In
Diane D.-S. Tang-Liu +5 more
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