Results 231 to 240 of about 10,864 (278)
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Expert Opinion on Investigational Drugs, 1997
Brimonidine tartrate is a highly selective alpha2-adrenergic receptor agonist indicated for the chronic treatment of glaucoma and ocular hypertension. Glaucoma, a serious worldwide public health problem causing blindness in 5.2 million people, is treated by drugs that lower the intraocular pressure (IOP), a primary risk factor in glaucomatous optic ...
L. B. Cantor, J. Burke
openaire +6 more sources
Brimonidine tartrate is a highly selective alpha2-adrenergic receptor agonist indicated for the chronic treatment of glaucoma and ocular hypertension. Glaucoma, a serious worldwide public health problem causing blindness in 5.2 million people, is treated by drugs that lower the intraocular pressure (IOP), a primary risk factor in glaucomatous optic ...
L. B. Cantor, J. Burke
openaire +6 more sources
European Journal of Ophthalmology, 2023
Objective To compare objective ocular redness measured using OCULUS Keratograph 5 M before and after 0.2% brimonidine instillation in glaucoma patients under topical hypotensive treatment.
Elena Montolío-Marzo +6 more
semanticscholar +1 more source
Objective To compare objective ocular redness measured using OCULUS Keratograph 5 M before and after 0.2% brimonidine instillation in glaucoma patients under topical hypotensive treatment.
Elena Montolío-Marzo +6 more
semanticscholar +1 more source
Journal of Ocular Pharmacology and Therapeutics, 2023
Purpose: Brimonidine is a highly alpha-2 adrenergic agonist, which provides a potential myopia control effect. This study aimed to examine the pharmacokinetics and concentration of brimonidine in the posterior segment tissue of eyes in guinea pigs ...
Aiqun Xiang +6 more
semanticscholar +1 more source
Purpose: Brimonidine is a highly alpha-2 adrenergic agonist, which provides a potential myopia control effect. This study aimed to examine the pharmacokinetics and concentration of brimonidine in the posterior segment tissue of eyes in guinea pigs ...
Aiqun Xiang +6 more
semanticscholar +1 more source
Expert Opinion on Drug Safety, 2010
Brimonidine is a drug used in the management of glaucoma throughout the world and is the most modern alpha(2)-adrenoceptor agonist available. This review comprehensively discusses the use of brimonidine for glaucoma.A historical insight into the development of selective adrenergic glaucoma drugs is given, followed by a description of the mechanisms of ...
Mamun Q. Rahman +2 more
openaire +2 more sources
Brimonidine is a drug used in the management of glaucoma throughout the world and is the most modern alpha(2)-adrenoceptor agonist available. This review comprehensively discusses the use of brimonidine for glaucoma.A historical insight into the development of selective adrenergic glaucoma drugs is given, followed by a description of the mechanisms of ...
Mamun Q. Rahman +2 more
openaire +2 more sources
Preclinical evaluation of brimonidine
Survey of Ophthalmology, 1996Preclinical studies of brimonidine show that it is a potent alpha 2-adrenoceptor agonist that is 1000-fold more selective for the alpha 2-vs. the alpha 1-adrenoceptor, and is 7-12-fold more alpha 2-selective than clonidine and 23- to 32-fold more alpha 2-selective than apraclonidine (p-aminoclonidine).
James A. Burke, Michal Schwartz
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Brimonidine Induced Anterior Uveitis
Ocular Immunology and Inflammation, 2015To present the largest series reported so far of brimonidine induced granulomatous anterior uveitis.Retrospective chart review of patients with chronic glaucoma on treatment with brimonidine presenting with anterior uveitis.19 eyes of 12 patients with chronic glaucoma developed anterior uveitis with granulomatous keratic precipitates after being ...
Ehud Zamir, Jacqueline Beltz
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The benefit of scratch patch testing to demonstrate ocular contact allergy to brimonidine tartrate
Contact Dermatitis, 2022Ocular allergies to brimonidine are frequent in patients treated for glaucoma. There is variability in reporting due to the lack of diagnostic criteria and the absence of cutaneous testing.
J. Ringuet +4 more
semanticscholar +1 more source
Can bleeding in trabeculectomy be decreased? Effectiveness of brimonidine pre-treatment
European Journal of Ophthalmology, 2022Purpose To evaluate the efficacy of preoperative topical brimonidine use to maintain visibility during trabeculectomy and control intraoperative bleeding and postoperative subconjunctival hemorrhage.
F. Ucar, H. Yener
semanticscholar +1 more source
Preclinical Safety Profile of Brimonidine
European Journal of Ophthalmology, 1996Brimonidine is a selective α2-adrenergic agonist developed for lowering intraocular pressure in glaucoma patients. Since brimonidine will be used in long-term theraphy, the safety of this drug is an important feature for its clinical success. Brimonidine has been evaluated in a number of safety studies using doses much greater than those in humans. In
Diane D.-S. Tang-Liu +5 more
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Brimonidine tartrate for the treatment of glaucoma
Expert Opinion on Pharmacotherapy, 2018Brimonidine tartrate is a commonly used eyedrop for short- and long-term lowering of intraocular pressure. Its use has been popularized due to its effects on aqueous suppression and uveoscleral outflow, as well as the suggestion of neuroprotection. Although available with alternative preservative vehicles, brimonidine is associated with high rates of ...
Judy L. Chen +3 more
openaire +3 more sources