Results 81 to 90 of about 7,499 (195)

Soluble Guanylate Cyclase α1–Deficient Mice: A Novel Murine Model for Primary Open Angle Glaucoma [PDF]

, 2013
Primary open angle glaucoma (POAG) is a leading cause of blindness worldwide. The molecular signaling involved in the pathogenesis of POAG remains unknown.
Abernathy, Emma, Alt, Clemens, Arora, Pankaj, Bloch, Kenneth Daniel, Brouckaert, Peter, Buys, Emmanuel, Clerté, Maeva, de Waard, Nadine, Giani, Andrea, Gong, Haiyan, Gregory, Meredith S., Hayton, Sarah R., Jones, Alexander, Kang, Jae Hee Hee, Ko, Yu-Chieh, Ksander, Bruce R., Lin, Charles P., Loomis, Stephanie J., Malhotra, Rajeev, Nathan, Daniel, Oh, Dong-Jin, Pasquale, Louis, Ren, Ruiyi, Rhee, Douglas J, Scherrer-Crosbie, Marielle, Tainsh, Laurel T., Tainsh, Robert Edward Tillinghast, Turcotte, Raphael, Wiggs, Janey Lee, Yu, Binglan   +29 more
core   +5 more sources

Sulphur Analogues of Homoisoflavonoids as Potential Treatments for Neovascular Eye Diseases

ChemMedChem, Volume 21, Issue 2, January 2026.
Neovascular eye diseases are characterised by the abnormal growth of often fragile blood vessels in the eye. Treatment focuses on reducing angiogenesis as well as reducing oxidative stress induced inflammation, a key underlying cause. Synthetic sulphur analogues of naturally occurring homoisoflavonoids, synthesised in three steps, have shown promise as
Jacob D. Hiles, Ola Deri, Kamakshi Sishtla, Joseph C. Bear, Jeremy K. Cockcroft, Elizabeth I. Opara, Ali A. Al‐Kinani, Raid G. Alany, Timothy W. Corson, Sianne L. Schwikkard   +9 more
wiley   +1 more source

Treating Glaucoma with Porous Contact Lens

, 2008
Glaucoma is a family of diseases that afflicts 65 million people worldwide. Primary open angle glaucoma is the most common type of glaucoma. This is characterized by increased intraocular pressure (IOP) within the eye that results in vision loss. Current
Adams, Amie, Glass, Zachary, Schmidt, Gretchen, Xie, Jeanne   +3 more
core  

Effect of a fixed combination of ripasudil and brimonidine on aqueous humor dynamics in mice

Scientific Reports
Ripasudil–brimonidine fixed-dose combination (K-232) simultaneously targets three different intraocular pressure (IOP) lowering mechanisms, increasing trabecular meshwork outflow and uveoscleral outflow, and reducing aqueous humor production Vascularly ...
Reiko Yamagishi-Kimura, Megumi Honjo, Makoto Aihara   +2 more
doaj   +1 more source

New and emerging technologies for the treatment of inherited retinal diseases: a horizon scanning review. [PDF]

, 2015
The horizon scanning review aimed to identify new and emerging technologies in development that have the potential to slow or stop disease progression and/or reverse sight loss in people with inherited retinal diseases (IRDs).
Michaelides, M, Moore, AT, Simpson, S, Smith, J, Ward, D   +4 more
core  

Magnetic Resonance Imaging of Optic Nerve Traction During Adduction in Primary Open-Angle Glaucoma With Normal Intraocular Pressure. [PDF]

, 2017
PurposeWe used magnetic resonance imaging (MRI) to ascertain effects of optic nerve (ON) traction in adduction, a phenomenon proposed as neuropathic in primary open-angle glaucoma (POAG).MethodsSeventeen patients with POAG and maximal IOP ≤ 20 mm Hg, and
Bonelli, Laura, Caprioli, Joseph, Clark, Robert A, Coleman, Anne L, Demer, Joseph L, Giaconi, JoAnn A, Law, Simon K, Nouri-Mahdavi, Kouros, Suh, Soh Youn   +8 more
core   +1 more source

Brimonidine prevents axonal and somatic degeneration of retinal ganglion cell neurons

Molecular Neurodegeneration, 2011
Background Brimonidine is a common drug for lowering ocular pressure and may directly protect retinal ganglion cells in glaucoma. The disease involves early loss of retinal ganglion cell transport to brain targets followed by axonal and somatic ...
Crish Samuel D, Ruiz Lupe, Lambert Wendi S, Wheeler Larry A, Calkins David J   +4 more
doaj   +1 more source

Acute bilateral simultaneous angle closure glaucoma after topiramate administration: a case report [PDF]

, 2008
Introduction A case of severe acute bilateral angle closure glaucoma with complete visual loss after oral topiramate therapy. Case presentation A 34 year-old woman developed bilateral severe visual loss 2 days after doubling the dosage of topiramate. Her
Kakarla V Chalam, Tina Tillis, Farhana Syed, Swati Agarwal, Vikram S Brar, JT Banta, J Levy, FW Fraunfelder, JE Craig, FA Medeiros, SD Silberstein, E Eisenberg, P Raskin, N Celebisoy, BA Johnson   +14 more
core   +1 more source

Effects of the timolol-dorzolamide fixed combination and latanoprost on circadian diastolic ocular perfusion pressure in glaucoma. [PDF]

, 2008
PURPOSE. To evaluate the effect of the timolol-dorzolamide fixed combination (TDFC) and latanoprost 0.005% on 24-hour intraocular pressure (IOP), systolic (SBP) and diastolic (DBP) blood pressure, and diastolic ocular perfusion pressure (DOPP) in ...
Floriani I., Konstas A.G.P., Miglior S., Pizzolante T., Quaranta L.   +4 more
core   +1 more source

The efficacy and safety of add-on 0.1% brimonidine tartrate preserved with sodium chlorite in on-treatment Japanese normal-tension glaucoma patients

Clinical Ophthalmology, 2014
Toyoaki Tsumura,1 Keiji Yoshikawa,2 Tairo Kimura,3 Hirotaka Suzumura,4 Miwako Kawashima,5 Mami Nanno,6 Kiyotaka Ishijima,7 Ryuji Takeda8 1Fussa Hospital, Tokyo, Japan; 2Yoshikawa Eye Clinic, Tokyo, Japan; 3Ueno Eye Clinic, Tokyo, Japan; 4Suzumura Eye ...
Tsumura T, Yoshikawa K, Kimura T, Suzumura H, Kawashima M, Nanno M, Ishijima K, Takeda R   +7 more
doaj