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Brimonidine and brinzolamide for treating glaucoma and ocular hypertension; a safety evaluation
Expert Opinion on Drug Safety, 2017Brimonidine tartrate and brinzolamide eye drops are often used as third and fourth line treatment options to reduce intraocular pressure (IOP) in the management of glaucoma and ocular hypertension. Better tolerated, more effective topical agents requiring once daily instillation including prostaglandin analogues and beta-blockers usually are preferred ...
Ivan Goldberg
exaly +4 more sources
Effects of topical administration of 1% brinzolamide on normal cat eyes
Veterinary Ophthalmology, 2003AbstractObjective To evaluate the effect of short‐term daily topical administration of 1% brinzolamide on the intraocular pressure (IOP) of healthy domestic cats with normotensive eyes and to assess the potential for negative side effects of drug administration.Animals Twelve privately owned adult domestic cats without physical or ocular abnormalities ...
R. V. Morgan, A. M. Willis, H. E. Gray
exaly +4 more sources
Drugs & Aging, 2009
Brinzolamide 1%/timolol 0.5% fixed combination (brinzolamide/timolol) is a twice-daily eyedrops suspension comprising the carbonic anhydrase-II inhibitor brinzolamide and the beta-adrenergic receptor antagonist timolol. Brinzolamide/timolol produced clinically relevant reductions in mean intraocular pressure (IOP) from baseline and was more effective ...
Jamie D. Croxtall, Lesley J. Scott
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Brinzolamide 1%/timolol 0.5% fixed combination (brinzolamide/timolol) is a twice-daily eyedrops suspension comprising the carbonic anhydrase-II inhibitor brinzolamide and the beta-adrenergic receptor antagonist timolol. Brinzolamide/timolol produced clinically relevant reductions in mean intraocular pressure (IOP) from baseline and was more effective ...
Jamie D. Croxtall, Lesley J. Scott
openaire +2 more sources
Topical brinzolamide for foveal schisis in juvenile retinoschisis
Journal of American Association for Pediatric Ophthalmology and Strabismus, 2013We describe a case series of 4 consecutive patients diagnosed with X-linked retinoschisis seen at a pediatric ophthalmology clinic during a 3-year period. All patients were treated with topical brinzolamide; 3 patients experienced significantly decreased severity of macular cysts on OCT in at least one eye.
Seo Wei Leo +2 more
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Topical brinzolamide in congenital nystagmus: A retrospective study
Archivos de la Sociedad Española de Oftalmología (English Edition), 2017To evaluate the effect of treatment with topical brinzolamide on visual acuity and nystagmus intensity in patients with congenital nystagmus.A retrospective study was designed in which the clinical records of 14 patients with congenital nystagmus were reviewed. All patients underwent a complete ophthalmological examination and a Perea video-oculography
B. Domingo Gordo +11 more
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Expert Opinion on Pharmacotherapy, 2008
Primary open-angle glaucoma is a multifactorial optic neuropathy characterized by the progressive loss of retinal ganglion cells and their axons. However, the primary risk factor is elevated intraocular pressure (IOP), which can damage the optic nerve head (ONH) and until now was the only treatable risk factor.
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Primary open-angle glaucoma is a multifactorial optic neuropathy characterized by the progressive loss of retinal ganglion cells and their axons. However, the primary risk factor is elevated intraocular pressure (IOP), which can damage the optic nerve head (ONH) and until now was the only treatable risk factor.
openaire +3 more sources
Brinzolamide-loaded Soft Contact Lens for Ophthalmic Delivery
Therapeutic Delivery, 2022Aim: In this study, brinzolamide (BRZ) was loaded in balafilcon A silicone hydrogel soft contact lens to enhance delivery in glaucoma therapy. Materials & methods: BRZ-loaded soft contact lens was prepared by the soaking method with optimization of pH, temperature and concentration of drug loading solution.
Liza Marie, C De Guzman +2 more
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Effect of Travoprost and Brinzolamide on ocular hemodynamics
Acta Ophthalmologica Scandinavica, 2007Abstract Purpose: To investigate the effect of topical travoprost and brinzolamide on retrobulbar flow velocities and ocular pulse amplitude in glaucoma patients. Methods: Twenty patients with glaucoma underwent color doppler imaging of the central retinal, temporal and nasal short posterior ciliary and ophthalmic artery, as well as Pascal dynamic ...
Ingeborg Stalmans +3 more
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Ophthalmology, 2014
To compare the intraocular pressure (IOP)-lowering efficacy and safety of brinzolamide 1% and brimonidine 0.2% fixed combination (BBFC) with that of brinzolamide 1% or brimonidine 0.2% monotherapy, all dosed 2 times per day (BID).Six-month, phase 3, randomized, multicenter, double-masked clinical trial.A total of 560 patients with primary open-angle ...
James D. Branch +5 more
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To compare the intraocular pressure (IOP)-lowering efficacy and safety of brinzolamide 1% and brimonidine 0.2% fixed combination (BBFC) with that of brinzolamide 1% or brimonidine 0.2% monotherapy, all dosed 2 times per day (BID).Six-month, phase 3, randomized, multicenter, double-masked clinical trial.A total of 560 patients with primary open-angle ...
James D. Branch +5 more
openaire +3 more sources