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Brinzolamide plus brimonidine for the treatment of glaucoma: an update
Expert Opinion on Pharmacotherapy, 2014Glaucoma is a common sight-threatening condition that is primarily treated by lowering intraocular pressure (IOP). Today the mainstay of treatment is topical ocular hypotensive medications; many patients require more than one agent to achieve target IOP.
Sky K. H. Chew +2 more
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Ophthalmology, 2008
To compare the safety and intraocular pressure (IOP)-lowering efficacy of brinzolamide 1%/timolol 0.5% fixed combination with brinzolamide 1% or timolol 0.5% alone in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT).Randomized, double-masked, parallel group, multicenter study.Five hundred twenty-three patients were randomized to the
Martin B Kaback +8 more
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To compare the safety and intraocular pressure (IOP)-lowering efficacy of brinzolamide 1%/timolol 0.5% fixed combination with brinzolamide 1% or timolol 0.5% alone in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT).Randomized, double-masked, parallel group, multicenter study.Five hundred twenty-three patients were randomized to the
Martin B Kaback +8 more
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Preclinical Overview of Brinzolamide1
Survey of Ophthalmology, 2000The development of topically active carbonic anhydrase inhibitors (CAIs) is a significant recent achievement in glaucoma medical treatment. Brinzolamide, the newest topical CAI, exhibits selectivity, high affinity, and potent inhibitory activity for the carbonic anhydrase type II isozyme (CA-II), which is involved in aqueous humor secretion.
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Effects of Brinzolamide on Aqueous Humor Dynamics in Monkeys and Rabbits
Journal of Ocular Pharmacology and Therapeutics, 2003This study examines the mechanisms by which brinzolamide reduces intraocular pressure (IOP) in healthy rabbits and in monkeys with unilateral ocular hypertension. Intraocular pressures were measured by pneumatonometry and aqueous flow was determined by fluorophotometry before and after three twice-daily drops of 1% brinzolamide to both eyes per monkey ...
Marsha A. McLaughlin +2 more
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Development of inclusion complex of brinzolamide with hydroxypropyl-β-cyclodextrin
Carbohydrate Polymers, 2013Glaucoma is an accumulative optic neuropathy resulted from increasing intraocular pressure. Brinzolamide (BRZ) is a kind of carbonic anhydrase inhibitors for glaucoma treatment. In this study, brinzolamide-hydroxypropyl-β-cyclodextrin (BRZ-HP-β-CD) inclusion complex was prepared by solvent evaporation method to improve the solubility of BRZ and enhance
Xiangrong Song +10 more
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Medical control of intraocular pressure with brinzolamide 1% after phacoemulsification
Canadian Journal of Ophthalmology, 2008To compare the effectiveness of only 1 drop of topical brinzolamide 1% with dosing every 12 hours and with no ocular hypotensive medication following clear corneal phacoemulsification surgery.This prospective, randomized, double-blind study was composed of 60 eyes of 60 patients who underwent uneventful clear corneal phacoemulsification surgery under ...
Erkin Kir, Harun Çakmak, Volkan Dayanir
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Effect of brinzolamide and dorzolamide on aqueous humor flow in human eyes
American Journal of Ophthalmology, 1999To measure the relative efficacy of brinzolamide hydrochloride 1% ophthalmic suspension, a new carbonic anhydrase inhibitor, compared with the currently used dorzolamide hydrochloride 2% ophthalmic solution as suppressors of aqueous humor flow in human eyes, and to study the difference of effect during the day and at night.A randomized, double-masked ...
Cory Ingram, Richard F. Brubaker
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Retinal Peripapillary Blood Flow before and after Topical Brinzolamide
Ophthalmologica, 2004<i>Purpose:</i> To study the effect of topical brinzolamide on retinal capillary blood flow by the Heidelberg Retina Flowmeter (HRF) in patients with glaucoma. <i>Methods:</i> Twenty patients with glaucoma were consecutively recruited. One eye for each patient was randomly selected.
IESTER, MICHELE +5 more
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The intraocular pressure reducing effect of brinzolamide as adjunctive therapy to latanoprost
Current Medical Research and Opinion, 2011To determine the intraocular pressure (IOP) lowering effect of brinzolamide when added to latanoprost.Patients who were simultaneously on brinzolamide and latanoprost were identified from the large prospective database of patients diagnosed with primary open angle glaucoma, normal tension glaucoma or ocular hypertension maintained in our glaucoma ...
Donald M. I. Montgomery +1 more
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Short-Term Effect of Topical Brinzolamide on Human Central Corneal Thickness
European Journal of Ophthalmology, 2008Purpose To investigate the effect of short-term brinzolamide application on human central corneal thickness (CCT). Methods Seventeen eyes of 16 patients who underwent neodymium:YAG laser posterior capsulotomy were included in the study group. Twenty-two subjects served as controls.
Örnek, K. +3 more
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