FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
East Anglian early Neolithic monument burial linked to contemporary Megaliths
Annals of Human Biology, 2019 In the fourth millennium BCE a cultural phenomenon of monumental burial structures spread along the Atlantic façade. Megalithic burials have been targeted for aDNA analyses, but a gap remains in East Anglia, where Neolithic structures were generally ...
Christiana L. Scheib +11 more
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
British dilemma and hypocrisy in the NPT regime vis-à-vis South Africa
Contree, 2016 The international non-proliferation regime has focused on developing strategies to halt the development of nuclear technology, particularly in developing regions.
Lucky E. Asuelime, Anna-Mart van Wyk
doaj +1 more source
Black Lives Matter in London, June 2020: Patrick Hutchinson, instant celebrity, and changing discourses of race and class in British media [PDF]
, 2022 Jude Davies
openalex +1 more source
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Trading in traditions : New Zealand's exports to the countries of the European Union, 1960 to 2000 : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in History at Massey University [PDF]
, 2004 New Zealand has always been a nation strongly reliant on international trading. From the mid-nineteenth century wool was a major export commodity and with the advent of refrigeration in the 1880s sheepmeat and dairy products, especially butter,gained ...
Davenport, Carol
core
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
The Falklands War and the British Stage
Romanian Journal of English Studies, 2014 The paper examines the way the Falklands War of 1982 was reflected in the creation of British playwrights. Officially, the war was seen as a heroic act, as another glorious page in the book of British history.
Radu Adrian
doaj +1 more source
The financial crisis of 1825 and the restructuring of the British financial system [PDF]
Banks and banking - History ; Banks and banking - Great Britain ; Great Britain ; Financial crises - Great ...
Larry Neal
core