Results 81 to 90 of about 594,538 (299)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Ordnance Survey of Great Britain [cartographic material] : England & Wales.
, 1948 Relief shown by gradient tints, contours and spot heights.; "National grid, military system"; "Outline edition"--Sheet 11.; Each sheet is numbered and named individually.; Includes insets, index to adjoining sheets, and grid reference.; Topographic map ...
Great Britain. Ordnance Survey.
core
, 2015 Early photographic work from Billingham's series 'Rays a Laugh' xhibited in 'Art and Alcohol', Tate Britain, London, (16 November 2015 - 30 September 2016) curated by David Blayney Brown.
Billingham, Richard, Tate Britain
core +3 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Geological survey of Great Britain (Scotland) [cartographic material] /
, 1968 various eds. Geological map series of Scotland showing geological periods, sedimentary rocks, metamorphic rocks, metasedimentary rocks and meta-igneous rocks. Relief shown by contours, hachures, and spot heights.
Great Britain. Ordnance Survey.
core
ALLIANZ POLITIK IN DER SUEZKRISE 1956
Вестник Кемеровского государственного университета, 2014 The problem of NATO's crisis during the Suez crisis in 1956 (military intervention of Britain, France and Israel to prevent the strengthening of Egypt in the Suez Canal zone) is analyzed in the paper.The author examines the position of the leading NATO ...
T. Freiberger
doaj
Katar’da Osmanlı Hâkimiyetine Tarihsel Bir Bakış
Vakanüvis Uluslararası Tarih Araştırmaları Dergisi, 2019 Bu çalışmada temel olarak Yavuz Sultan Selim'in Mısır seferiyle Katar’ın Osmanlı himayesine girmesinden 1915 yılında son askerimizin Katar’dan çıkmasına kadar geçen süreyi irdeledik.
Dummar BİNGÖL
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source