Results 81 to 90 of about 199,040 (253)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The Last Reform in Macedonia: The British-Russian Reform Bill (8 March 1908)
Yakın Dönem Türkiye AraştırmalarıMacedonia, which was acquired by the Ottoman Empire from Bulgaria through the Berlin Treaty and mandated to undergo reforms, became a region of conflicting interests involving European countries and various ethnic groups.
Nuran Koltuk
doaj +1 more source
, 2006 Questions of asylum and immigration have taken centre stage in national and international debate and figure prominently in the domestic political agendas of wealthy states and nations. In Australia, Europe and the US, harsh and punitive asylum and immigration laws are being enacted incrementally and asylum-seekers are subject increasingly to detention.
openaire +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Rusya, İngiltere ve Doğu Rumeli Vilayetinin Kuruluşu
Vakanüvis Uluslararası Tarih Araştırmaları Dergisi, 2018 1877 – 1878 Osmanlı Rus savaşından sonra imzalanan Ayestefanos Antlaşması neticesinde ortaya çıkan “Büyük Bulgaristan” ideali Büyük Doğu Krizi sürecinde sarsılan Avrupa güç dengesinde daha derin krizler ortaya çıkardı. İngiltere ve Avusturya-Macaristan
Nadezhda VASİLEVA VASİLEVA
doaj
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source