Results 81 to 90 of about 1,879,820 (319)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Housing price volatility and downsizing in later life [PDF]

, 2007
In this paper, we modeled several types of housing transitions of the elderly in two countries -- Britain and the United States. One important form of these transitions involves downsizing of housing consumption, the importance of which among older ...
Banks, J., Blundell, R., Oldfield, Z., Smith, J.P.   +3 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Freedom, Sincerity, and the Modern Woman in the Interwar Romances of Berta Ruck

Journal of Popular Romance Studies, 2022
Berta Ruck’s interwar romance novels address contemporary anxieties about the changing role of women in Britain after 1918. Ruck’s novels focus both on the modern woman in contrast to the Victorian woman, and the extent to which modernity and the new ...
Bonnie White
doaj  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Multifunctionality and Ecumenism in Post-War British Church Architecture: Two Projects by Martin Purdy

Histories of Postwar Architecture
In the period following the Second World War, both the Roman Catholic Church and the Church of England underwent profound transformations, driven by the influence of the Liturgical Movement.
Lorenzo Grieco
doaj   +1 more source

The Approach to Shiite Studies in British Academic Institutes [PDF]

Journal of Islamic Political Studies
In contemporary British academic institutes and centers, a range of research is conducted on the Islamic world, including Shiite studies. British researchers have for long asserted that their approach to Islamic and Shiite studies is historical, claiming
Ahmad Vaezi, Omid Alipour Olyaei, Hamidreza Shariatmadari   +2 more
doaj   +1 more source

Betting on Dog Racing. The Next Legalised Gambling Opportunity in South Africa? A Cautionary Note from the Regulation of Greyhound Racing in Great Britain

, 2010
This article commences with a brief overview of the history of dog racing in South Africa. It provides a synopsis of South Africa’s current legal position on dog racing and the betting thereon. The main question this article addresses is whether there is
Carnelley, Marita
core  

Book review: who cares?: public ambivalence & government activism from the New Deal to the second gilded age [PDF]

, 2011
Alastair Hill finds some important advice for both Barack Obama and David Cameron on the ‘policy moods’ in Britain and ...
Hill, Alastair
core  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source