Results 101 to 110 of about 7,144,441 (302)

The genome sequence of an ichneumonid wasp, Exephanes ischioxanthus (Gravenhorst, 1829) [version 1; peer review: 2 approved, 1 approved with reservations]

Wellcome Open Research
We present a genome assembly from an individual male Exephanes ischioxanthus (an ichneumonid wasp; Arthropoda; Insecta; Hymenoptera; Ichneumonidae). The genome sequence is 284.0 megabases in span.
Gavin R. Broad
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The genome sequence of Langmaid’s Yellow Underwing moth, Noctua janthina (Denis & Schiffermüller) 1775 [version 1; peer review: 2 approved]

Wellcome Open Research
We present a genome assembly from an individual male Noctua janthina (Langmaid’s Yellow Underwing; Arthropoda; Insecta; Lepidoptera; Noctuidae). The genome sequence has a total length of 539.70 megabases.
Gavin R. Broad
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors

Nature Communications
A central challenge in cancer research is to identify the secreted factors that sustain tumor cell survival. This is best exemplified in Hodgkin lymphoma, where malignant cells constitute a minor fraction of the tumor and rely on signals from the ...
Vignesh Shanmugam, Neriman Tokcan, Daniel Chafamo, Sean Sullivan, Mehdi Borji, Haley Martin, Gail Newton, Naeem Nadaf, Saoirse Hanbury, Irving Barrera, Dylan Cable, Jackson Weir, Orr Ashenberg, Geraldine Pinkus, Scott Rodig, Caroline Uhler, Evan Macosko, Margaret Shipp, Abner Louissaint, Fei Chen, Todd R. Golub   +20 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Learning representations for image-based profiling of perturbations

Nature Communications
Measuring the phenotypic effect of treatments on cells through imaging assays is an efficient and powerful way of studying cell biology, and requires computational methods for transforming images into quantitative data.
Nikita Moshkov, Michael Bornholdt, Santiago Benoit, Matthew Smith, Claire McQuin, Allen Goodman, Rebecca A. Senft, Yu Han, Mehrtash Babadi, Peter Horvath, Beth A. Cimini, Anne E. Carpenter, Shantanu Singh, Juan C. Caicedo   +13 more
doaj   +1 more source

The genome sequence of the Marbled Minor moth, Oligia strigilis (Linnaeus, 1758) [version 1; peer review: 2 approved]

Wellcome Open Research
We present a genome assembly from an individual male Oligia strigilis (Marbled Minor; Arthropoda; Insecta; Lepidoptera; Noctuidae). The genome sequence is 626.1 megabases in span.
Gavin R. Broad
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source