Results 41 to 50 of about 2,414 (194)

New 2,3-Benzodiazepine Derivative: Synthesis, Activity on Central Nervous System, and Toxicity Study in Mice

Pharmaceuticals, 2021
We report the design and synthesis of a new diazepine derivative, 4-(4-methoxyphenyl)-2,3,4,5-tetrahydro-2,3-benzodiazepin-1-one (VBZ102), and the evaluation of its anxiolytic-like profile, memory impairment effect, and toxicity in Swiss mice. VBZ102 was
Amal Amaghnouje, Serhii Bohza, Nathalie Bohdan, Imane Es-Safi, Andrii Kyrylchuk, Sanae Achour, Hinde El Fatemi, Dalila Bousta, Andriy Grafov   +8 more
doaj   +1 more source

Comorbidity Between Recurrent Major Depressive Disorder and CADASIL: A Case Report With a Brief Review of Published Cases. [PDF]

Clin Case Rep
ABSTRACT Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) may underlie mood disorders by directly affecting cerebral vascular function and neural networks, thereby contributing to or worsening mood symptoms.
Wang YM, Yu HY, Zhang L, Hu C.
europepmc   +2 more sources

Comparative effectiveness, safety and acceptability of pharmacological and psychosocial interventions for the treatment of cannabis use disorder: A network meta‐analysis

Addiction, EarlyView.
Abstract Aim Our primary aim was to conduct a network meta‐analysis (NMA) for the effectiveness, safety and acceptability of all psychosocial interventions and all pharmacotherapies for cannabis use disorder (CUD). Methods We conducted a NMA of studies identified from two completed systematic reviews examining the effectiveness, safety and ...
Monika Halicka, Francesca Spiga, Tom P. Freeman, Suzanne Nielsen, Jelena Savović, Julian P. T. Higgins, Deborah M. Caldwell   +6 more
wiley   +1 more source

A Comparative Study between Screen-Printed and Solid-Contact Electrodes for the Stability-Indicating Determination of Bromazepam

Molecules, 2022
Stability-indicating methods are awesome tools to ensure the safety and efficacy of active pharmaceutical ingredients (APIs). An accurate comparative study involving the use of potentiometric sensors for the determination of bromazepam (BRZ) in the ...
Sherif A. Abdel-Gawad, Ali Altharawi
doaj   +1 more source

Risks Associated With Benzodiazepine Long‐Term Use in Chronic Insomnia: A Systematic Review and (Network) Meta‐Analysis

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT This systematic literature review evaluated the risks of using benzodiazepine medications for more than 3 months in adults with chronic insomnia. Chronic insomnia is defined as ongoing dissatisfaction with sleep quantity or quality, causing significant distress and impaired functioning during the day.
Dieter Riemann, Chiara Baglioni, Christoph Nissen, Agathe Nevière, Omar Irfan, Pauline Le Nouveau, Chrysoula Leontiou, Damien Léger   +7 more
wiley   +1 more source

Phytoextraction of Bromazepam [PDF]

, 2016
The aim of this bachelor thesis was to determine the possibility of phytoextraction of benzodiazepine bromazepam as a widely used drug with anxiolytic effects.
Konečná, Markéta
core  

Development of a validated HPLC method for the separation and analysis of a Bromazepam, Medazepam and Midazolam mixture

Journal of Pharmaceutical Analysis, 2012
The purpose of this work was to develop a rapid, sensitive and validated HPLC method for the separation and analysis of a Bromazepam, Medazepam and Midazolam mixture. The three benzodiazepine compounds were separated on a reversed-phase C18 column at 50 °
Hasan al-Hawasli, Mohammad Ammar al-Khayat, Mohammad Amer al-Mardini   +2 more
doaj   +1 more source

Anxiolytic, Antidepressant-Like Proprieties and Impact on the Memory of the Hydro-Ethanolic Extract of Origanum majorana L. on Mice

Applied Sciences, 2020
Marjoram (Origanum majorana L.) infusion has been used as folk medicine against depression and anxiety. However, no studies have been carried out yet to prove those activities scientifically.
Amal Amaghnouje, Hamza Mechchate, Imane Es-safi, Amal A. Alotaibi, Omar M. Noman, Fahd A. Nasr, Mohammed Al-zharani, Pierfrancesco Cerruti, Anna Calarco, Hinde EL Fatemi, Andriy Grafov, Dalila Bousta   +11 more
doaj   +1 more source

Assessing the Existence of Pharmaceutical Compounds in Hospital Treated Wastewater (Case Study: Sedatives in One of the Hospitals in District 11 of Tehran) [PDF]

محیط زیست و مهندسی آب, 2020
Hospital wastewater is one of the most infectious and dangerous wastewaters that may contain large amounts of pathogenic microorganisms, dangerous pollutants of various hormones.
Leila Rahimvand, Nooshin Sajadi
doaj   +1 more source

Effects of baclofen and lorazepam on interhemispheric inhibition in humans

Experimental Physiology, Volume 111, Issue 8, Page 3818-3827, 1 August 2026.
Abstract Transcallosal projections within the corpus callosum allow for the transfer of information between bilateral primary motor cortices (M1). Interhemispheric inhibition (IHI) is one approach to probe transcallosal communication using transcranial magnetic stimulation (TMS) whereby the motor evoked potential (MEP) elicited by TMS is reduced in ...
Faith C. Adams, Karishma R. Ramdeo, Malaikah Ahmad, Stevie D. Foglia, Chloe C. Drapeau, Mustaali Hussain, Jiyeon Park, Mark A. Tarnopolsky, Aimee J. Nelson   +8 more
wiley   +1 more source