Results 171 to 180 of about 486,581 (309)

Dual Nickel/Photoredox‐Catalyzed Regio‐ and Enantioselective Alkenylation of Epoxides

open access: yesAdvanced Science, EarlyView.
Ni/photoredox‐catalyzed stereoconvergent cross‐electrophile coupling of racemic epoxides with alkenyl bromides is described, affording β‐alkenyl products with up to 95% ee, excellent E‐selectivity, and complete regiocontrol. These versatile intermediates enable diverse chiral synthons; mechanistic studies suggest a halide ring‐opening followed by ...
Hongyan Lan   +4 more
wiley   +1 more source

Profile of inhaled glycopyrronium bromide as monotherapy and in fixed-dose combination with indacaterol maleate for the treatment of COPD

open access: yes, 2015
Anoop Prakash,1 K Suresh Babu,2 Jaymin B Morjaria1,31Department of Respiratory Medicine, Castle Hill Hospital, Cottingham, 2Department of Respiratory Medicine, Queen Alexandra Hospital, Cosham, Portsmouth, 3Department of Academic Respiratory Medicine ...
Prakash A, Morjaria JB, Babu KS
core  

Imperfect Oriented Attachment of Gold Nanoparticles

open access: yesAdvanced Science, EarlyView.
The cover illustrates the imperfect oriented attachment of gold nanoparticles in liquid, as revealed by in situ liquid‐phase transmission electron microscopy. Triggered by the abrupt collapse of the interfacial hydration layer, two misoriented nanoparticles undergo a kinetically driven “jump‐to‐coalescence”.
Fangjie Meng   +7 more
wiley   +1 more source

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

open access: yesAdvanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song   +7 more
wiley   +1 more source

Discovery of 2-(2-Benzoyl-5-Phenyl-<i>1H</i>-Imidazol-1-Yl) Derivatives as Inhibitors of Factor XIIa. [PDF]

open access: yesChemistrySelect
Al-Horani RA   +7 more
europepmc   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

open access: yesAdvanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian   +13 more
wiley   +1 more source

First hotel, Bromide, Oklahoma.

open access: yes
First hotel, Bromide ...

core  

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