Bromocriptine improves glucose tolerance in obese mice via central dopamine D2 receptor-independent mechanism. [PDF]
Bromocriptine, generally regarded as a dopamine D2 receptor agonist, has been used to treat patients with type 2 diabetes in the USA; however, its mechanisms of action including the receptors that mediate its anti-diabetic effects remain unclear ...
Hiroshi Tsuneki+11 more
doaj +2 more sources
Atherosclerosis enhances the efficacy of liposome-encapsulated bromocriptine in reducing the incidence of prolactinemia in pituitary tumors [PDF]
Intranasal drug delivery via nanocarriers has long been a research focus for enhancing drug concentration in the brain. However, the strategy of exploiting blood–brain barrier (BBB) alterations in atherosclerotic mouse models to enhance nanoparticle ...
Zhe Zhang+12 more
doaj +2 more sources
Is Abrupt Withdrawal of Benzodiazepines a Risk Factor for Neuroleptic Malignant Syndrome? A Case Report With Single-Dose Haloperidol. [PDF]
ABSTRACT Neuroleptic malignant syndrome (NMS) is a rare but life‐threatening reaction associated with the use of dopamine‐modulating agents, which presents with symptoms like high fever, muscle rigidity, and autonomic instability. It is known that both the use of dopamine receptor antagonists and the sudden withdrawal of dopamine receptor agonists can ...
Abbasi B, Elyasi F, Aliyali M.
europepmc +2 more sources
Benzodiazepine and Opioid Withdrawal Induced Neuroleptic Malignant Like Syndrome: A Clinical Case Report With Management Complexities. [PDF]
This case report describes a 54‐year‐old man who developed Neuroleptic Malignant‐like Syndrome (NMLS) following the abrupt withdrawal of high‐dose benzodiazepines and opioids. The report highlights the diagnostic challenges in differentiating NMLS from Neuroleptic Malignant Syndrome and emphasizes the critical role of GABAergic dysregulation in its ...
Abbasi B+3 more
europepmc +2 more sources
HYPOTHERMIC ACTION OF BROMOCRIPTINE [PDF]
The body temperature of rats has been studied in a cold environment. In this setting, bromocriptine induced hypothermia. This fall in core temperature was inhibited by pimozide. It was concluded that bromocriptine has a dopamine‐like action in areas of the brain concerned with the control of body temperature, as has previously been shown for ...
D.B. Calne, L.E. Claveria, J.L. Reid
openaire +5 more sources
Revisiting Late-Onset Bipolar Disorder Associated With Pituitary Adenoma: A Cross-Sectional, Multidisciplinary, Case-Based Analysis. [PDF]
Surveying 300 neurologists, psychiatrists, and family physicians, this study demonstrates discipline‐specific strengths‐imaging (neurology), diagnosis (psychiatry), and pharmacological follow‐up (family medicine)‐yet persistent gaps in holistic care of late‐onset bipolar disorder in elders.
Fidan YS+6 more
europepmc +2 more sources
Study on Synergistic Effect of Bromocriptine and Sitagliptin in Streptozotocin-induced Diabetic Rats [PDF]
Introduction: Diabetes mellitus is a potentially morbid condition with high prevalence worldwide. Restoration of euglycemia in type 2 diabetes mellitus is difficult to achieve due to its multifactorial pathogenesis and frequently requires multiple ...
Govindaraj Nileshraj+3 more
doaj +1 more source
The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas
Background Prolactinoma is a functional pituitary adenoma that secretes excessive prolactin. Dopamine agonists (DAs) such as bromocriptine (BRC) are the first-line treatment for prolactinomas, but the resistance rate is increasing year by year, creating ...
Shuman Wang+6 more
doaj +1 more source
Impact of Nano-Bromocriptine on Egg Production Performance and Prolactin Expression in Layers
The current study aimed to investigate the potential use of nano-bromocriptine in improving the laying performance of late laying hens by modulating the prolactin gene expression.
Ahmed Dawod+7 more
doaj +1 more source
Bromocriptine in Parkinsonism [PDF]
Bromocriptine, a drug acting directly upon dopaminergic receptors, has been found to have a significant therapeutic action in a double-blind study of 20 patients with idiopathic Parkinsonism who were already receiving conventional therapy, including levodopa.
L. E. Claveria+5 more
openaire +3 more sources