Results 21 to 30 of about 12,259 (202)

Oncogenic driver and therapeutic target: Prolactin signalling axis in retroperitoneal sarcoma. [PDF]

Clin Transl Med
Retroperitoneal sarcoma cells can secrete prolactin into the bloodstream, inducing hyperprolactinaemia, which subsequently triggers metabolic reprogramming, such as glucose metabolism. SOX4 can function as a transcription factor that facilitates PRL transcription.
Xie F, Gu L, Yang K, Wang S, Xiao M, Yan G, Zhang Q, Liang R, Zhuang A, Xi Z, Niu Y, Chen Y, Xia X, Qu L, Zhao B, Li W, Wu T, Yu C, Luo C, Wang H, Lian L, Li W.   +21 more
europepmc   +2 more sources

Bromocriptine approved as the first medication to target dopamine activity to improve glycemic control in patients with type 2 diabetes

Diabetes, Metabolic Syndrome and Obesity, 2010
Michael A Via1, Himani Chandra2, Takako Araki1, Matthew V Potenza3, Maria Skamagas41Division of Endocrinology and Metabolism, Albert Einstein College of Medicine, Beth Israel Medical Center, New York, NY, USA; 2Division of Endocrinology, Diabetes and ...
Via MA
doaj   +2 more sources

Bromocriptine in peripartum cardiomyopathy: A meta‐analysis with trial sequential analysis [PDF]

ESC Heart Failure
Bromocriptine has been proposed as a disease‐modifying therapy for peripartum cardiomyopathy (PPCM). The long‐term outcomes of bromocriptine use remain uncertain.
Umar G. Adamu, Kabo Mojela, Kamilu M. Karaye, Nqoba Tsabedze   +3 more
doaj   +2 more sources

Clinical response and patient's tolerance of vaginal versus oral bromocriptine in women who suffers hyperprolactinaemia [PDF]

Zagazig University Medical Journal, 2021
Hyperprolactinaemia is areal challenge for gynecologist and endocrinologists ,bromocriptine was used for treating hyperprolactinaemia ,bromocriptine associated with many side effect this study aimed to compare clinical response , side effects and ...
mostafa abdelfattah, anwer esmaiel, Mona Elsayed mostafa, wael nossir   +3 more
doaj   +1 more source

Management of posttraumatic refractory paroxysmal sympathetic hyperactivity with bromocriptine: a case report [PDF]

Journal of Trauma and Injury
This case report describes a unique instance of refractory paroxysmal sympathetic hyperactivity (PSH) in a 19-year-old woman following a traumatic brain injury sustained in a motorcycle accident.
Min-Seok Woo, Seong-Hyun Park, Jeong-Hyun Hwang, Chaejin Lee   +3 more
doaj   +2 more sources

Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine

iScience, 2022
Summary: Bromocriptine is approved as a diabetes therapy, yet its therapeutic mechanisms remain unclear. Though bromocriptine’s actions have been mainly attributed to the stimulation of brain dopamine D2 receptors (D2R), bromocriptine also targets the ...
Despoina Aslanoglou, Suzanne Bertera, Laura Friggeri, Marta Sánchez-Soto, Jeongkyung Lee, Xiangning Xue, Ryan W. Logan, J. Robert Lane, Vijay K. Yechoor, Peter J. McCormick, Jens Meiler, R. Benjamin Free, David R. Sibley, Rita Bottino, Zachary Freyberg   +14 more
doaj   +1 more source

Study on Synergistic Effect of Bromocriptine and Sitagliptin in Streptozotocin-induced Diabetic Rats [PDF]

Journal of Clinical and Diagnostic Research, 2021
Introduction: Diabetes mellitus is a potentially morbid condition with high prevalence worldwide. Restoration of euglycemia in type 2 diabetes mellitus is difficult to achieve due to its multifactorial pathogenesis and frequently requires multiple ...
Govindaraj Nileshraj, Chandrasekaran Swithraa, Murugesan Sakthibalan, Maruti Shripati Sawadkar   +3 more
doaj   +1 more source

The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas

BMC Endocrine Disorders, 2021
Background Prolactinoma is a functional pituitary adenoma that secretes excessive prolactin. Dopamine agonists (DAs) such as bromocriptine (BRC) are the first-line treatment for prolactinomas, but the resistance rate is increasing year by year, creating ...
Shuman Wang, Aihua Wang, Yu Zhang, Kejing Zhu, Xiong Wang, Yonggang Chen, Jinhu Wu   +6 more
doaj   +1 more source

Impact of Nano-Bromocriptine on Egg Production Performance and Prolactin Expression in Layers

Animals, 2021
The current study aimed to investigate the potential use of nano-bromocriptine in improving the laying performance of late laying hens by modulating the prolactin gene expression.
Ahmed Dawod, Noha Osman, Hanim S. Heikal, Korany A. Ali, Omaima M. Kandil, Awad A. Shehata, Hafez M. Hafez, Hamada Mahboub   +7 more
doaj   +1 more source

Bromocriptine inhibits proliferation in the endometrium from women with adenomyosis

Frontiers in Endocrinology, 2023
ObjectiveBromocriptine treatment has been shown to reduce menstrual bleeding and pain in women with adenomyosis in a pilot clinical trial. The underlying mechanism contributing to the treatment effect is however unknown.
Yiqun Tang, Sakthivignesh Ponandai-srinivasan, Caroline Frisendahl, Johanna K. Andersson, Dora Pavone, Elizabeth A. Stewart, Parameswaran Grace Luther Lalitkumar, Eberhard Korsching, Nageswara Rao Bogavarappu, Kristina Gemzell-Danielsson   +9 more
doaj   +1 more source