Results 1 to 10 of about 49,296 (268)

Acromegaly [PDF]

Nature Reviews Disease Primers, 2019
Acromegaly is characterized by increased release of growth hormone and, consequently, insulin-like growth factor I (IGF1), most often by a pituitary adenoma. Prolonged exposure to excess hormone leads to progressive somatic disfigurement and a wide range
Annamaria Colao, Shlomo Melmed, Andrea Giustina   +2 more
exaly   +11 more sources

The acromegaly lipodystrophy

Frontiers in Endocrinology, 2022
Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) are essential to normal growth, metabolism, and body composition, but in acromegaly, excesses of these hormones strikingly alter them.
Pamela U. Freda
doaj   +2 more sources

A Consensus Statement on acromegaly therapeutic outcomes

Nature Reviews Endocrinology, 2018
The 11th Acromegaly Consensus Conference in April 2017 was convened to update recommendations on therapeutic outcomes for patients with acromegaly. Consensus guidelines on the medical management of acromegaly were last published in 2014; since then, new ...
Shlomo Melmed, Marcello D Bronstein, Philippe Chanson   +2 more
exaly   +2 more sources

Real-world burden of disease, treatment, and healthcare resource utilization in acromegaly: a quantitative survey of patient experiences [PDF]

Journal of Patient-Reported Outcomes
Background Acromegaly is a rare endocrine disease caused by excessive growth hormone (GH) secretion typically due to a pituitary adenoma. Patients ineligible for or with an inadequate response to surgery and/or radiotherapy often require pharmacotherapy ...
Maxwell Koobatian, Jill Sisco, Janetricks C. Okeyo, Alan Krasner, Tiffany P. Quock   +4 more
doaj   +2 more sources

Patient reported outcome data from acromegaly patients treated with injectable somatostatin receptor ligands (SRLs) in routine clinical practice

BMC Endocrine Disorders, 2020
Background Acromegaly patients managed on Somatostatin receptor ligands (SRLs), the most common first-line pharmacotherapy for acromegaly, may still experience acromegaly symptoms such as headache, sweating, fatigue, soft tissue swelling, and joint pain,
Eliza B. Geer, Jill Sisco, Daphne T. Adelman, William H. Ludlam, Asi Haviv, Shuqian Liu, Susan D. Mathias, Dana Gelbaum, Lizheng Shi   +8 more
doaj   +2 more sources

Insulin Resistance in Patients With Acromegaly

Frontiers in Endocrinology, 2019
Acromegaly is characterized by chronic overproduction of growth hormone (GH) that leads to insulin resistance, glucose intolerance and, ultimately, diabetes. The GH-induced sustained stimulation of lipolysis plays a major role not only in the development
Greisa Vila, Jens Otto L. Jørgensen, Anton Luger, Günter K. Stalla   +3 more
doaj   +2 more sources

Consensus on criteria for acromegaly diagnosis and remission

Pituitary, 2023
Purpose The 14th Acromegaly Consensus Conference was convened to consider biochemical criteria for acromegaly diagnosis and evaluation of therapeutic efficacy. Methods Fifty-six acromegaly experts from 16 countries reviewed and discussed current evidence
Andrea Giustina, N. Biermasz, F. Casanueva, M. Fleseriu, Pietro Mortini, C. Strasburger, A. J. van der Lely, J. Wass, S. Melmed, Giuseppe Ariel Albert Martin Cesar Thierry Michael Philippe Banfi Barkan Beckers Bidlingmaier Boguszewski Brue, Giuseppe Banfi, A. Barkan, Albert Beckers, M. Bidlingmaier, C. Boguszewski, T. Brue, M. Buchfelder, Philippe Chanson, S. Chiloiro, Annamaria Colao, Eva C. Coopmans, Daniela Esposito, D. Ferone, S. Frara, M. Gadelha, E. Geer, E. Ghigo, Y. Greenman, M. Gurnell, Ken K. Y. Ho, A. Ioachimescu, G. Johannsson, Jens Otto Lunde Jørgensen, U. B. Kaiser, N. Karavitaki, L. Katznelson, S. Lamberts, M. Losa, A. Luger, R. Luque, P. Maffei, Mónica Marazuela, S. Neggers, Alberto M. Pereira, L. Persani, S. Petersenn, Martin Reincke, Roberto Salvatori, Susan N. Samson, Katharina Schilbach, Ilan Shimon, S. Tsagarakis, M. Zatelli   +52 more
semanticscholar   +1 more source

Association of Epicardial Adipose Tissue Thickness with Cardiovascular Risk in Acromegaly

Medeniyet Medical Journal, 2022
Objective: Acromegaly is a rare disease associated with increased mortality. Reports on coronary artery disease in acromegaly are controversial. This study aimed to investigate the possible association of epicardial adipose tissue thickness with ...
Bulent CAN, Fatma OLCAY COSKUN, Sercin OZKOK, Mumtaz TAKIR   +3 more
doaj   +1 more source

Old Wine in a New Bottle: Acromegaly Presenting as Diabetic Ketoacidosis [PDF]

Journal of Clinical and Diagnostic Research, 2021
Acromegaly is a rare disease characterised by chronic excess of Growth Hormone (GH) levels. Insulin signalling is impaired, gluconeogenesis is excess and peripheral insulin resistance is increased in acromegaly causing hyperglycaemia and diabetes ...
Sowrabha Bhat, Subhodip Pramanik, Pradip Mukhopadhyay, Subhankar Chowdhury   +3 more
doaj   +1 more source

Gene Expression Signature in Adipose Tissue of Acromegaly Patients. [PDF]

, 2014
To study the effect of chronic excess growth hormone on adipose tissue, we performed RNA sequencing in adipose tissue biopsies from patients with acromegaly (n = 7) or non-functioning pituitary adenomas (n = 11).
Barkan, Ariel L, Bridges, Dave, Chandler, William F, Hochberg, Irit, Saltiel, Alan R, Tran, Quynh T   +5 more
core   +13 more sources