Results 41 to 50 of about 49,296 (268)

Pasireotide Long-Acting Release Treatment for Diabetic Cats with Underlying Hypersomatotropism [PDF]

, 2017
BACKGROUND: Long‐term medical management of hypersomatotropism (HS) in cats has proved unrewarding. Pasireotide, a novel somatostatin analogue, decreases serum insulin‐like growth factor 1 (IGF‐1) and improves insulin sensitivity in cats with HS when ...
Abraham, Berg, Bruns, Church, Colao, Colao, Combes, Cozzi, Dowling, Dunning, Feelders, Freda, Gadelha, Henry, Hofland, Hubina, Hussaini, Jaffe, Katznelson, Kurosaki, Lamb, Laron, Ma, Meij, Meij, Myers, Niessen, Niessen, Niessen, Patel, Petersenn, Peterson, Reubi, Reusch, Reusch, Sathyapalan, Schaefer, Scudder, Shanik, Slingerland, Slingerland, Theodoropoulou, Tyson, Zambre   +43 more
core   +3 more sources

Incidence of Benign and Malignant Tumors in Patients with Acromegaly is Increased: a Nationwide Population-Based Study.

Journal of Clinical Endocrinology and Metabolism, 2021
CONTEXT Whether cancer risk in acromegaly is increased remains controversial. Also, the risk of benign tumors has been little studied. OBJECTIVE To investigate the incidence of benign and malignant tumors in acromegaly in a nationwide population-based ...
D. Esposito, O. Ragnarsson, G. Johannsson, Daniel S Olsson   +3 more
semanticscholar   +1 more source

E-cadherin expression is associated with somatostatin analogue response in acromegaly [PDF]

, 2018
Acromegaly is a rare disease resulting from hypersecretion of growth hormone (GH) and insulin‐like growth factor 1 (IGF1) typically caused by pituitary adenomas, which is associated with increased mortality and morbidity. Somatostatin analogues (SSAs)
Cano, David A., Castaño, Justo P., Dios, Elena, Flores Martínez, Álvaro, Ibáñez Costa, Alejandro, Japón Rodríguez, Miguel Ángel, Luque, Raúl M., Madrazo Atutxa, Ainara, Soto Moreno, Alfonso Manuel, Venegas Moreno, Eva, Vázquez Borrego, Mari C.   +10 more
core   +1 more source

Advances in Research on the Cardiovascular Complications of Acromegaly

Frontiers in Oncology, 2021
Cardiovascular-related complications are one of the most common complications in patients with acromegaly, and can lead to an increased risk of death. Hypertension and cardiomyopathy are the main cardiovascular complications.
Han Yang, Huiwen Tan, He Huang, Jianwei Li   +3 more
semanticscholar   +1 more source

Pasireotide for the Medical Management of Feline Hypersomatotropism [PDF]

, 2015
BACKGROUND: Feline hypersomatotropism (HST) is a cause of diabetes mellitus in cats. Pasireotide is a novel multireceptor ligand somatostatin analog that improves biochemical control of humans with HST.
Abraham, Adams, Alt, Appleton, Bhayana, Bruns, Castillo, Church, Colao, Colao, Cuevas-Ramos, Fedele, Fernandez-Rodriguez, Fougner, Golor, Henry, Hofland, Juul, Katznelson, Kvols, Lamb, Lamberts, Maxwell, Meij, Miller, Murray, Myers, Niessen, Niessen, Niessen, Niessen, Petrus, Polska, Rand, Ray, Schmid, Schmid, Sheppard, Slingerland, Sohmiya, Starkey, Stolk, Taboada, Wajchenberg, Zatelli, Zou   +45 more
core   +2 more sources

Prolonged Diagnostic Delay in Acromegaly is Associated with Increased Morbidity and Mortality.

European Journal of Endocrinology, 2020
CONTEXT Clinical features of acromegaly develop insidiously. Its diagnosis may therefore be delayed. OBJECTIVE Our aim was to study diagnostic delay and its impact on morbidity and mortality in a nationwide cohort of patients with acromegaly.
D. Esposito, O. Ragnarsson, G. Johannsson, Daniel S Olsson   +3 more
semanticscholar   +1 more source

Genetics of Acromegaly and Gigantism

Journal of Clinical Medicine, 2021
Growth hormone (GH)-secreting pituitary tumours represent the most genetically determined pituitary tumour type. This is true both for germline and somatic mutations.
A. Bogusławska, M. Korbonits
semanticscholar   +1 more source

Disease and Treatment-Related Burden in Patients With Acromegaly Who Are Biochemically Controlled on Injectable Somatostatin Receptor Ligands

Frontiers in Endocrinology, 2021
Medical treatment for acromegaly commonly involves receiving intramuscular or deep subcutaneous injections of somatostatin receptor ligands (SRLs) in most patients.
M. Fleseriu, M. Molitch, A. Dreval, N. Biermasz, M. Gordon, R. Crosby, W. Ludlam, A. Haviv, Y. Gilgun-Sherki, S. Mathias   +9 more
semanticscholar   +1 more source

Growth hormone nadir during oral glucose load depends on waist circumference, gender and age: normative data in 231 healthy subjects. [PDF]

, 2011
Objective  (i) To analyse the predictors of GH suppression after standard glucose load (oGTT) in the healthy population and (ii) to establish the 97th percentile of GH nadir post-oGTT according to these variables.
AURIEMMA, RENATA SIMONA, COLAO, ANNAMARIA, GALDIERO, MARIANO, GRASSO, LUDOVICA FRANCESCA STELLA, LOMBARDI, GAETANO, PIVONELLO, CLAUDIA, PIVONELLO, ROSARIO, SAVASTANO, SILVIA   +7 more
core   +1 more source

Prevalence of vertebral fractures and serum sclerostin levels in acromegaly

Endocrine, 2021
An increased prevalence of vertebral fractures (VFs) has been reported in previous studies. The aim of this study was to evaluate the association between bone mineral density (BMD), bone turnover markers, serum sclerostin levels, and vertebral fractures (
M. M. Uygur, D. Yazıcı, Onur Buğdaycı, D. Yavuz   +3 more
semanticscholar   +1 more source