Results 61 to 70 of about 20,619 (221)

Treatment outcomes and mortality of 94 patients with acromegaly [PDF]

, 2005
Due to new therapeutic modalities and modified therapeutic goals outcome of patients with acromegaly may change over time and differ by centre.
Zwahlen, M, Christ, ER, Trepp, R, Seiler, R, Diem, P, Stettler, C   +5 more
core   +1 more source

Unexplained massive pulmonary embolism in acromegaly patient: A case report

Clinical Case Reports
Key Clinical Message Our case highlights the importance of recognizing acromegaly as a potential risk factor for venous thromboembolism (VTE). Despite a thorough thrombophilia workup yielding unremarkable results, further research is warranted to ...
Usamah Al‐Anbagi, Shybin Usman, Abdulrahman Saad, Abdulqadir J. Nashwan   +3 more
doaj   +1 more source

Assessment of quality of life in patients with uncontrolled vs. controlled acromegaly using the Acromegaly Quality of Life Questionnaire (AcroQoL)

, 2005
Acromegaly is a chronic disease with an important impact on quality of life. An acromegaly disease-generated quality of life questionnaire (AcroQoL) has recently been developed.
Everts, Regula, Trepp, Roman, Webb, Susan M, Christ, Emanuel R, Allemann, Sabine, Stettler, Christoph, Fischli, Stefan   +6 more
core   +1 more source

Octreotide Counteracts IFN‐γ‐Induced Endothelial Inflammation

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 5, May 2026.
ABSTRACT Endothelial cells maintain vascular homeostasis through the regulation of permeability and coagulation. Interferon‐gamma (IFN‐γ), a proinflammatory cytokine released by activated T lymphocytes and natural killer cells, disrupts endothelial junctional integrity, leading to barrier dysfunction.
Saikat Fakir, Madan Sigdel, Md Matiur Rahman Sarker, Nektarios Barabutis   +3 more
wiley   +1 more source

A Zebrafish Acromegaly Model Elevates DNA Damage and Impairs DNA Repair Pathways

Biology, 2018
Acromegaly is a pathological condition due to excess growth hormone (GH) secretion. Acromegaly patients exhibit a deterioration of health and many associated complications, such as cardiovascular issues, arthritis, kidney diseases, muscular weakness, and
Abdalla Elbialy, Shuichi Asakawa, Shugo Watabe, Shigeharu Kinoshita   +3 more
doaj   +1 more source

Serial follow-up of presurgical treatment using pasireotide long-acting release with or without octreotide long-acting release for naive active acromegaly

, 2017
The aim of the present study was to evaluate the serial changes of GH and IGF-1 in seven patients with naive, active acromegaly following presurgical treatment of the somatostatin analog pasireotide long-acting release (LAR) and octreotide LAR.
Chang, Jan-Shun;Tseng, Ham-Min;Chang, Tien-Chun, 曾漢民;張天鈞   +1 more
core   +1 more source

Luteinizing hormone receptor knockout mouse: What has it taught us?

Andrology, Volume 14, Issue 4, Page 1017-1028, May 2026.
Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

A Case of Heart Failure With Reduced Ejection Fraction Secondary to Dilated Cardiomyopathy due to Long‐Standing Untreated Acromegaly: A Case Report and Focused Literature Review

Clinical Case Reports, Volume 14, Issue 4, April 2026.
Echocardiographic findings in dilated cardiomyopathy secondary to untreated acromegaly. (A) Apical four‐chamber view showing biventricular and biatrial dilation. (B‐C) Colour Doppler demonstrating mitral, aortic, and tricuspid regurgitation. (D) Reduced global longitudinal strain (GLS: −6.5%), consistent with severe systolic dysfunction.
Cristian Orlando Porras Bueno, Nancy Muriel Herrera Leaño, María Juliana Soto Chávez, Darío Parra Prieto, Alejandro Mariño Correa   +4 more
wiley   +1 more source

A Teenage Guitarist's Swollen Fingers

JEADV Clinical Practice, EarlyView.
Maho Matsuo, Hiroaki Iwata
wiley   +1 more source