Results 71 to 80 of about 23,277 (221)

Treatment outcomes and mortality of 94 patients with acromegaly [PDF]

, 2005
Due to new therapeutic modalities and modified therapeutic goals outcome of patients with acromegaly may change over time and differ by centre.
Zwahlen, M, Christ, ER, Trepp, R, Seiler, R, Diem, P, Stettler, C   +5 more
core   +2 more sources

Transcriptional Profiling of Growth Hormone–Secreting Pituitary Adenoma Stem‐Like Cells: Unveiling the Significant Role of CXCR4 in Tumorigenesis and Clinical Applications

MedComm, Volume 7, Issue 9, September 2026.
Growth hormone–secreting pituitary adenomas harbor hPASCs (human pituitary adenoma stem‐like cells). Genetic profiling of hPASCs identified CXCR4 as a significant gene orchestrating a regulatory network in the self‐renewal and differentiation of hPASCs, as well as the modulation of tumor cells and the microenvironment.
LinHao Yuan, Hao Yang, BaoWang Li, Huimin Sui, Peiliang Li, Xu Wang, Jiang Li, Guijun Jia, Zhaohui Zhu, Deling Li, Wang Jia, Peng Kang   +11 more
wiley   +1 more source

Serial follow-up of presurgical treatment using pasireotide long-acting release with or without octreotide long-acting release for naive active acromegaly

, 2017
The aim of the present study was to evaluate the serial changes of GH and IGF-1 in seven patients with naive, active acromegaly following presurgical treatment of the somatostatin analog pasireotide long-acting release (LAR) and octreotide LAR.
Chang, Jan-Shun;Tseng, Ham-Min;Chang, Tien-Chun, 曾漢民;張天鈞   +1 more
core   +1 more source

Cancer prevalence in patients with acromegaly: data from the acromegaly registry of the Moscow Region

Alʹmanah Kliničeskoj Mediciny
Background: The incidence of cancer in acromegaly varies substantially, ranging from 6.8% to 21.3%. Population-based studies have revealed differences both in the tumor types and in the risk factors for cancer development in acromegaly. Aim: To assess
Natalia I. Borovskaya, Maria V. Kats, Daria S. Mikhaylova, Yuliya A. Kukushkina, Valentina E. Shikina, Irena A. Ilovayskaya   +5 more
doaj   +1 more source

Voice Quality in Individuals With Acquired Immunodeficiency Syndrome

International Journal of Language &Communication Disorders, Volume 61, Issue 5, September/October 2026.
ABSTRACT Background Speech and voice disorders are frequently observed in individuals with acquired immunodeficiency syndrome (AIDS). However, the literature lacks detailed descriptions of how perceptual and acoustic characteristics manifest in the voice quality profiles of this population.
Vanessa Medina, Andrea Baldi de Freitas, Luiz Carlos Rusilo, Jean Carlo Gorinchteyn, Zuleica Antônia Camargo   +4 more
wiley   +1 more source

Prevalence of acromegaly in patients with symptoms of sleep apnea.

PLoS ONE, 2017
Acromegaly is a rare disease with nonspecific symptoms with acral enlargement being almost universally present at diagnosis. The estimated prevalence is 40-125 cases/million but targeted universal screening studies have found a higher prevalence (about ...
Gemma Sesmilo, Eugenia Resmini, Marcel Sambo, Concepción Blanco, Fernando Calvo, Fernando Pazos, Pablo Fernández-Catalina, Purificación Martínez de Icaya, Concepción Páramo, Carmen Fajardo, Mónica Marazuela, Cristina Álvarez-Escolá, Juan Jose Díez, Verónica Perea, ACROSAHS study group   +14 more
doaj   +1 more source

Midlife Growth Hormone Receptor Ablation Extends Healthy Lifespan and Induces Sex‐Specific Hepatic Transcriptional Changes at Single‐Cell Resolution

Aging Cell, Volume 25, Issue 9, September 2026.
Reducing growth hormone receptor signaling beginning in middle age is sufficient to extend lifespan in both sexes while preserving metabolic and physical function, particularly in males. Single‐nucleus RNA sequencing reveals sex‐specific hepatic transcriptional remodeling associated with these longevity benefits. ABSTRACT Suppression of growth hormone (
Silvana Duran‐Ortiz, Edward O. List, Jonathan A. Young, Yuji Ikeno, Shouan Zhu, Todd McHugh, Patrick M. O'Connor, Minhoo Kim, Bérénice A. Benayoun, Fabian Benencia, Reetobrata Basu, Emmanuel A. Gotte, Darlene E. Berryman, John J. Kopchick   +13 more
wiley   +1 more source

Assessment of quality of life in patients with uncontrolled vs. controlled acromegaly using the Acromegaly Quality of Life Questionnaire (AcroQoL)

, 2005
Acromegaly is a chronic disease with an important impact on quality of life. An acromegaly disease-generated quality of life questionnaire (AcroQoL) has recently been developed.
Everts, Regula, Trepp, Roman, Webb, Susan M, Christ, Emanuel R, Allemann, Sabine, Stettler, Christoph, Fischli, Stefan   +6 more
core   +1 more source

Healthcare utilization and costs among patients with acromegaly in the United States

Journal of Comparative Effectiveness Research
Aim: Recent evidence regarding the healthcare resource utilization (HCRU) and associated costs of acromegaly is limited. Materials & methods: This retrospective, cross-sectional administrative claims analysis (IQVIA Pharmetrics Plus) identified ...
Tiffany P Quock, Eunice Chang, Ashis K Das, Amanda Speller, Marian H Tarbox, Melinda L Rossi, Stacy K Rattana, Ingrid E Paulson, Michael S Broder   +8 more
doaj   +1 more source

Growth Hormone Receptor Antagonism Extends Lifespan

Aging Cell, Volume 25, Issue 9, September 2026.
This study provides proof of concept that GH antagonism in GH‐producing mice extends lifespan, supporting further investigation of GH antagonists as potential anti‐aging interventions in animals and humans. ABSTRACT Interventions that disrupt growth hormone (GH) action are recognized as some of the most potent methods for extending lifespan ...
Edward O. List, Darlene E. Berryman, Grace S. Lach, Delaney F. Minto, Keeley Weese, John J. Kopchick   +5 more
wiley   +1 more source