Results 81 to 90 of about 24,454 (211)

Self‐Assembly of Therapeutic Peptides for Enhanced Cancer Therapy: Strategies, Therapeutic Performance, and Future Perspectives

MedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.
Therapeutic peptide self‐assembly is governed by multiple non‐covalent interactions, enabling the construction of diverse supramolecular structures. These self‐assembled systems can be engineered through spontaneous self‐assembly of monomers, co‐assembly, or stimulus‐responsive strategies to improve tumor delivery efficiency.
Yuelin Fang, Xue Wan, Shihe Wang, Honglan Dai, Huiling Zeng, Nan Chen, Xinxin Zhang   +6 more
wiley   +1 more source

Prevalence of thyroid diseases in patients with acromegaly: results of an Italian multi-center study

, 2002
Acromegaly is frequently associated with the presence of thyroid disorders, however the exact prevalence is still controversial. An Italian multicenter study was performed on 258 patients with active acromegaly (high levels of IGF-I and lack of ...
E. Martino, L. Manetti, M. Arosio, G. Faglia, COLAO, ANNAMARIA, F. Camanni, Acromegaly Study Group of the Italian Society of Endocrinology, A. Liuzzi, A. M. Colao, G. Lombardi, S. Mariotti, LOMBARDI, GAETANO, M. Gasperi, R. Baldelli, S. Porretti, Gasperi, Maurizio   +15 more
core   +1 more source

Healthcare utilization and costs among patients with acromegaly in the United States

Journal of Comparative Effectiveness Research
Aim: Recent evidence regarding the healthcare resource utilization (HCRU) and associated costs of acromegaly is limited. Materials & methods: This retrospective, cross-sectional administrative claims analysis (IQVIA Pharmetrics Plus) identified ...
Tiffany P Quock, Eunice Chang, Ashis K Das, Amanda Speller, Marian H Tarbox, Melinda L Rossi, Stacy K Rattana, Ingrid E Paulson, Michael S Broder   +8 more
doaj   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie International Edition, Volume 65, Issue 45, 2 November 2026.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +1 more source

Disorders of carbohydrate metabolism and their relationship with the prevalence of cancer in patients with acromegaly – authors’ own observations [PDF]

, 2016
Background . Acromegaly is a rare chronic disease with an excessive secretion of growth hormone, which leads to characteristic changes in appearance, organ and metabolic complications and neoplasms, which are a significant cause of shortened survival ...
Maria Kurowska, Anna Oszywa-Chabros, Oszywa-Chabros, Anna, Malicka, Joanna, Marta Dudzińska, Agata Smoleń, Jerzy S. Tarach, Dudzińska, Marta, Tarach, Jerzy, Joanna Elżbieta Malicka, Kurowska, Maria, Smoleń, Agata   +11 more
core   +2 more sources

Clinical and economic burden among older adults with acromegaly in the United States

Journal of Comparative Effectiveness Research
Aim: To compare healthcare resource utilization (HCRU) and costs between older adults with and without acromegaly. Materials & methods: Using 2017–2022 100% Medicare Research Identifiable Files, we identified beneficiaries (≥65 years) with prevalent ...
Tiffany P Quock, Eunice Chang, Ashis K Das, Amanda Speller, Marian H Tarbox, Stacy K Rattana, Ingrid E Paulson, Michael S Broder   +7 more
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, Volume 38, Issue 61, 2 November 2026.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Multiple Machine Learning Algorithms for Predicting Postoperative Residual Tumor in Pituitary Neuroendocrine Tumors

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
An explainable random forest–based machine learning model accurately predicted postoperative residual tumors in PitNETs, with tumor size and Knosp grade as major predictors, offering a web‐based tool for individualized surgical risk assessment and precision management.
Mingrui Li, Chenyang Zhao, Guodong Tang, Yang Li, Qing Liu   +4 more
wiley   +1 more source

Treatment outcomes and mortality of 94 patients with acromegaly [PDF]

, 2005
Due to new therapeutic modalities and modified therapeutic goals outcome of patients with acromegaly may change over time and differ by centre.
Zwahlen, M, Christ, ER, Trepp, R, Seiler, R, Diem, P, Stettler, C, Christ ER, Seiler R, Stettler C, Diem P, Trepp R, Zwahlen M   +11 more
core   +2 more sources

Clinical and biochemical characteristics of patients with acromegaly and normal or increased prolactin levels

Alʹmanah Kliničeskoj Mediciny
Background: Prevalence of hyperprolactinemia in patients with acromegaly is 30 to 40%. Since recently, the necessity of screening for acromegaly in hyperprolactinemic patients with pituitary adenoma has been actively debated. The literature on this issue
Yuliya A. Kukushkina, Irena A. Ilovayskaya   +1 more
doaj   +1 more source