Results 91 to 100 of about 49,296 (268)

Luteinizing hormone receptor knockout mouse: What has it taught us?

Andrology, Volume 14, Issue 4, Page 1017-1028, May 2026.
Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley   +1 more source

A Zebrafish Acromegaly Model Elevates DNA Damage and Impairs DNA Repair Pathways

Biology, 2018
Acromegaly is a pathological condition due to excess growth hormone (GH) secretion. Acromegaly patients exhibit a deterioration of health and many associated complications, such as cardiovascular issues, arthritis, kidney diseases, muscular weakness, and
Abdalla Elbialy, Shuichi Asakawa, Shugo Watabe, Shigeharu Kinoshita   +3 more
doaj   +1 more source

Serum N-Terminal Type III Procollagen Propeptide: An Indicator of Growth Hormone Excess and Response to Treatment in Feline Hypersomatotropism [PDF]

, 2016
BACKGROUND: N‐terminal type III procollagen propeptide (PIIINP) is a biomarker of soft tissue proliferation. Hypersomatotropism (HS) is associated with soft tissue proliferation.
Church, D B, Forcada, Y, Kenny, P J, Keyte, S V, Niessen, S J M   +4 more
core   +3 more sources

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

A Case of Heart Failure With Reduced Ejection Fraction Secondary to Dilated Cardiomyopathy due to Long‐Standing Untreated Acromegaly: A Case Report and Focused Literature Review

Clinical Case Reports, Volume 14, Issue 4, April 2026.
Echocardiographic findings in dilated cardiomyopathy secondary to untreated acromegaly. (A) Apical four‐chamber view showing biventricular and biatrial dilation. (B‐C) Colour Doppler demonstrating mitral, aortic, and tricuspid regurgitation. (D) Reduced global longitudinal strain (GLS: −6.5%), consistent with severe systolic dysfunction.
Cristian Orlando Porras Bueno, Nancy Muriel Herrera Leaño, María Juliana Soto Chávez, Darío Parra Prieto, Alejandro Mariño Correa   +4 more
wiley   +1 more source

AIP and MEN1 mutations and AIP immunohistochemistry in pituitary adenomas in a tertiary referral center. [PDF]

, 2019
Background: Pituitary adenomas have a high disease burden due to tumor growth/ invasion and disordered hormonal secretion. Germline mutations in genes such as MEN1 and AIP are associated with early onset of aggressive pituitary adenomas that can be ...
Cano González, David A., Flores Martínez, Álvaro, Venegas Moreno, Eva   +2 more
core  

Evaluation and Diagnostic Potential of Serum Ghrelin in Feline Hypersomatotropism and Diabetes Mellitus [PDF]

, 2015
BACKGROUND: Ghrelin is a growth hormone secretagogue. It is a potent regulator of energy homeostasis. Ghrelin concentration is down‐regulated in humans with hypersomatotropism (HS) and increases after successful treatment. Additionally, ghrelin secretion
Appleton, Barkan, Bedendi, Belsito, Berg, Bhatti, Brearley, Briatore, Cappiello, Cummings, Dezaki, Dunning, Erdmann, Feldman, Freda, Gelling, Ida, Jenkins, Jensen, Kawamata, Kojima, Kojima, Kozakowski, Krzyzanowska-Świniarska, Martin, McLaughlin, Meij, Natalucci, Niessen, Niessen, Niessen, Niessen, Peino, Pöykkö, Reusch, Roemmler, Saad, Sofer, Soriano-Guillén, Takaya, Tschuor, Ueno, Yada   +42 more
core   +2 more sources

Acromegaly at diagnosis in 3173 patients from the Liège Acromegaly Survey (LAS) Database

Endocrine-Related Cancer, 2017
Acromegaly is a rare disorder caused by chronic growth hormone (GH) hypersecretion. While diagnostic and therapeutic methods have advanced, little information exists on trends in acromegaly characteristics over time.
P. Pétrossians, A. Daly, E. Natchev, L. Maione, K. Blijdorp, M. Sahnoun-Fathallah, R. Auriemma, A. Diallo, A. Hulting, D. Ferone, V. Hána, S. Filipponi, C. Sievers, C. Nogueira, C. Fajardo-Montañana, D. Carvalho, G. Stalla, M. Jaffrain-Rea, B. Delemer, A. Colao, T. Brue, S. Neggers, S. Zacharieva, P. Chanson, A. Beckers   +24 more
semanticscholar   +1 more source

MANAGEMENT OF ENDOCRINE DISEASE: Does gender matter in the management of acromegaly.

European Journal of Endocrinology, 2020
Gonadal steroids modulate the effects of GH, with oestrogens attenuating and androgens augmenting GH action. Whether these divergent effects influence the clinical manifestation, management and prognosis of acromegaly have not been carefully reviewed ...
N. Lenders, A. McCormack, K. Ho
semanticscholar   +1 more source

Hypertensive Urgency and Pulmonary Infiltrates: A Report of Three Cases

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Hypertensive urgency is commonly attributed to medication nonadherence, progression of essential hypertension, or secondary causes. However, in some patients, no clear precipitating factor is identified, despite repeated evaluations and the absence of target organ damage. Subclinical inflammatory conditions have been hypothesized as potential,
Mónica Contreras‐Moreira
wiley   +1 more source