Results 91 to 100 of about 24,454 (211)
A male patient presented at the age of 30 with classic clinical features of acromegaly and was found to have elevated growth hormone levels, not suppressing during an oral glucose tolerance test.
Nikolaos Kyriakakis +6 more
doaj +1 more source
Abstract Diffuse cranial vault hyperostosis is an uncommon finding and may present a diagnostic challenge in clinical and forensic practice. We report the case of a 53‐year‐old woman with a long‐standing history of epilepsy treated with phenytoin and sodium valproate who collapsed at home suddenly and died despite resuscitative efforts.
Maria Piagkou +7 more
wiley +1 more source
Acromegaly - a neuroendocrine pathology, caused by chronic overproduction of growth hormone. Chronic overproduction of somatotropin and insulin growth factor (IGF) is clinically expressed in gigantism or acromegaly.
E L Soyustova
core +1 more source
Hypertriglyceridemia: Causes, Consequences, Diagnosis, and Management
Hypertriglyceridemia (HTG) arises from the interplay between genetic susceptibility and secondary or precipitating factors, leading to dysregulated triglyceride‐rich lipoprotein (TRL) metabolism. Increased TRL production and impaired clearance promote distinct risk phenotypes: accumulation of apolipoprotein B(apoB)‐containing TRL remnants contributes ...
Shanshan Qi +9 more
wiley +1 more source
Hepatocyte‐specific GHR ablation is associated with hepatic and age‐related pathologies, triggering adipose‐liver crosstalk via elevated circulating GH and subsequent CD36‐dependent hepatic steatosis. This loss impairs STAT5b phosphorylation and enhances PPARγ nuclear activation, upregulating Pdk4 and Cd36 to drive mitochondrial dysfunction and ectopic
Kangkang Yang +7 more
wiley +1 more source
Assessment of Serum B-Arestin Level in Acromegaly Patients with Diabetes Mellitus
Background: Acromegaly is a rare endocrine disorder, with an annual incidence of 4 cases per million and a prevalence of 40 cases per million. The condition results from a pituitary adenoma that secretes growth hormone.
Hiba Ghassan Rajab +2 more
doaj +1 more source
Long‐standing growth hormone (GH) excess causes the skeletal clinical signs of acromegaly with typical changes in bone geometry, including increased cortical bone thickness (CBT).
Kristin Godang +8 more
doaj +1 more source
IMPROVE 2025: The 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence
ABSTRACT An international cohort of 161 clinicians and researchers from 19 countries attended the 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence (IMPROVE) in Prague, Czech Republic, on 2–4 July 2025. The aims of the meeting were to advance understanding of hyperphagia and obesity caused by defects in the melanocortin‐4 receptor
Jesús Argente +17 more
wiley +1 more source
Acromegaly, or hypersomatotropism, results from chronic, excessive secretion of growth hormone in the adult animal. The anabolic effects of growth hormone are exerted through the intermediary hormone, insulin-like growth factor 1, which is produced in the liver under the influence of growth hormone.
openaire +2 more sources
From gene regulation to membrane excitability: A new role for thyroid hormone in skeletal muscle
The Journal of Physiology, EarlyView.
Eric N. Jimenez‐Vazquez +1 more
wiley +1 more source

