Results 91 to 100 of about 32,807 (303)

Somatostatin and dopamine receptors as targets for medical treatment of Cushing's Syndrome [PDF]

, 2008
Somatostatin (SS) and dopamine (DA) receptors are widely expressed in neuroendocrine tumours that cause Cushing's Syndrome (CS). Increasing knowledge of specific subtype expression within these tumours and the ability to target these receptor subtypes ...
A Colao, A Colao, A Newman-Tancredi, A Saiardi, A Saveanu, A Saveanu, A Schonbrunn, AB Atkinson, AM Isidori, AM O’Carroll, AS Mahmoud-Ahmed, B Ambrosi, B Ueberberg, C Bruns, C Garcia, C Invitti, C Missale, C Missale, C. de Bruin, D Cervia, D Cervia, D Ferone, D Gaitan, D Morris, D Yin, DC Danila, DL Batista, DN Orth, DW Ray, E Mezey, F Amenta, F Castinetti, F Illouz, F Kelestimur, F Vignati, G Giustina, G Weckbecker, GI Uwaifo, GK Stalla, HA Schmid, HA Schmid, HL Fehm, I Ilias, I Shraga-Slutzky, J Hoek van der, J Hoek van der, J Jagannathan, J Kraicer, J Lindholm, J Newell-Price, J Stack, JB Tyrrell, JC Reubi, JM Farah Jr., JW Miller, KD Wu, L Petrini, L Stefaneanu, L. J. Hofland, LA Casulari, LJ Hofland, LJ Hofland, LJ Hofland, LK Nieman, M Locatelli, M Phlipponneau, M Rocheville, M Tallent, ME Molitch, ML Vance, MR Brown, MZ Strowski, N Unger, N Unger, P Barnett, P Brazeau, P Jaquet, P Jaquet, P Ma, P Petrossians, PJ Stafford, R Day, R Hall, R Pivonello, R Pivonello, R Pivonello, R Pivonello, R Pivonello, R Pivonello, R Pivonello, R Schade, R Zanettini, R. A. Feelders, RJ Benveniste, RJ Croughs, S. W. J. Lamberts, SL Lightman, SW Lamberts, SW Lamberts, SW Lamberts, SW Lamberts, SW Lamberts, SW Lamberts, SW Lamberts, SW Lamberts, SW Lamberts, SW Lamberts, T Antakly, T Miyoshi, UI Richardson, VG Rasmussen, WE Farrell, WW Herder de, WW Herder de, X Bertagna, YC Patel   +115 more
core   +3 more sources

Bromocriptine for “negative” schizophrenia

Comprehensive Psychiatry, 1991
The hypothesis that the pathophysiology of negative symptoms in schizophrenia may involve relative hypoactivity of central dopaminergic neurotransmission prompts the exploration of dopamine agonist strategies in the treatment of this condition. Although the use of dopamine agonists in otherwise unmedicated schizophrenic patients often leads to the ...
Paul C. Bermanzohn, Paul C. Bermanzohn, Sergio Levi-Minzi, Samuel G. Siris, Samuel G. Siris   +4 more
openaire   +3 more sources

Ropinirole Functions Through a Dopamine Receptor D2‐Independent Mechanism to Ameliorate Amyotrophic Lateral Sclerosis Phenotypes in TARDBP‐Mutant iPSC‐Derived Motor Neurons

Journal of Neurochemistry, Volume 169, Issue 8, August 2025.
Ropinirole, a dopamine D2 receptor (DRD2) agonist, protects motor neurons harboring ALS‐linked TARDBP mutations via both DRD2‐dependent and DRD2‐independent mechanisms. Notably, the DRD2‐independent pathway inhibits elevated reactive oxygen species (ROS), abnormal gene expression, aberrant RNA splicing, and neuronal hyperexcitation—key pathogenic ...
Hirotsugu Asano, Tetsuya Kawaguchi, Chris Kato, Satoru Morimoto, Masato Yano, Maki Minaguchi, Daisuke Yasuda, Komei Fukushima, Hideyuki Okano   +8 more
wiley   +1 more source

Overexpression of the short isoform of the dopamine D2 receptor causes diet‐induced obesity and hyperglycemia in mice

Journal of Neuroendocrinology, Volume 37, Issue 8, August 2025.
Alterations in the expression levels of D2S and D2L resulted in obesity and metabolic syndrome such as abdominal fat accumulation and hyperglycemia in D2L KO mice fed with a high‐fat diet, compared to WT mice. This may be partly due to increased food intake.
Hanna Gonzalez, Lei Cheng, Qing Chang, Paul E. Gold, Diego Perez‐Tilve, YanYan Wang   +5 more
wiley   +1 more source

Dopa-responsive dystonia and hyperprolactinaemia : a novel association in two sisters [PDF]

, 2007
Dopa-Responsive Dystonia (DRD) is a rare hereditary condition of childhood-onset dystonia which responds dramatically to treatment with levodopa. It was first described in 1971 as a "hereditary progressive basal ganglia disease with marked diurnal ...
Cachia, Mario J., Galea, Janabel
core  

Litter sex composition influences plasma prolactin levels but not the melanin‐concentrating hormone immunoreactive neurons in the medial preoptic area of late lactating Long‐Evans rats

Journal of Neuroendocrinology, Volume 37, Issue 8, August 2025.
Influence of litter sex composition on maternal prolactin levels and MCH‐immunoreactive (MCH‐ir) neurons in the vmMPOA of lactating rats. The sex ratio of litters affects maternal physiology, specifically increasing prolactin levels and altering weight gain patterns, while food and water intake and MCH‐ir neuron counts remain unchanged.
Ammir Y. Helou, Camila de Carvalho, Larissa A. do Carmo, Jackson C. Bittencourt   +3 more
wiley   +1 more source

Using Artificial Intelligence Tools as Second Reviewers for Data Extraction in Systematic Reviews: A Performance Comparison of Two AI Tools Against Human Reviewers

Cochrane Evidence Synthesis and Methods, Volume 3, Issue 4, July 2025.
ABSTRACT Background Systematic reviews are essential but time‐consuming and expensive. Large language models (LLMs) and artificial intelligence (AI) tools could potentially automate data extraction, but no comprehensive workflow has been tested for different review types.
T. Helms Andersen, T. M. Marcussen, A. D. Termannsen, T. W. H. Lawaetz, O. Nørgaard   +4 more
wiley   +1 more source

iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid β Combination for Alzheimer’s Disease [PDF]

, 2017
In the process of drug development, in vitro studies do not always adequately predict human-specific drug responsiveness in clinical trials. Here, we applied the advantage of human iPSC-derived neurons, which offer human-specific drug responsiveness, to ...
Arai Tetsuaki, Asada Takashi, Funayama Misato, Imamura Keiko, Inoue Haruhisa, Iwata Nobuhisa, Izumi Yuishin, Kaji Ryuji, Kawakatsu Shinobu, Kondo Takayuki, Miyake Michiyo, Nakagawa Masato, Ohta Akira, Tsukita Kayoko, Woltjen Knut, 新井 哲明   +15 more
core   +1 more source

Relationship of serum prolactin with severity of drug use and treatment outcome in cocaine dependence. [PDF]

, 2004
RATIONALE: Alteration in serum prolactin (PRL) levels may reflect changes in central dopamine activity, which modulates the behavioral effects of cocaine.
Berrettini, Wade H., Certa, Kenneth M., Mannelli, Paolo, Murray, Heather, Patkar, Ashwin A., Peindl, Kathleen, Vergare, Michael J.   +6 more
core   +1 more source

Natural Killer cells responsiveness to physical esercise: a brief review [PDF]

, 2013
Natural killer cells (NK) are a group of peripheral blood lymphocytes which display cytotoxic ac- tivity against a wide range of tumour cells. They are a consistent part of the inflammatory re- sponse that is activated when either internal or external ...
Concu A., CRISAFULLI, ANTONIO, Melis F, MILIA, RAFFAELE, TOCCO, FILIPPO   +4 more
core   +1 more source