Results 71 to 80 of about 11,153 (206)
Different ATP13A2 mutations associated with Kufor‐Rakeb Syndrome (KRS) result in varying levels of intracellular iron accumulation. Frameshift and deletion mutations lead to excessive iron accumulation and increased cell death, whereas missense mutations cause milder functional impairment, resulting in lower iron accumulation and reduced cellular ...
Ezgi Erterek +7 more
wiley +1 more source
Transfer of bromocriptine across the blood-brain barrier in man
The transfer of 14C-bromocriptine across the blood-brain barrier was studied in 10 patients using the double indicator single injection method. The extraction (E) of bromocriptine was 8 % (quartiles: 6 and 14 %).
Hertz, M M, Paulson, O B, Friis, M L
core +1 more source
Loss of INPP5A in PitNETs disrupts IP3 clearance and drives aberrant PI3K/Akt activation. PKA‐dependent phosphorylation stabilizes MBD2 via 14‐3‐3σ, sustaining transcriptional silencing of INPP5A. MBD2 inhibition sensitizes tumors to standard treatments and limits PitNET growth.
Qian Jiang +12 more
wiley +1 more source
Bromocriptine treatment rapidly lowers the serum prolactin (PRL) level in PRL-secreting adenomas in rats as well as humans. Accompanying immunohistochemical and electron microscopic studies of the adenoma cells treated with bromocriptine for a short ...
丹羽, 潤, 水無頼, 昂
core +1 more source
Bromocriptine does not alter speed-accuracy tradeoff. [PDF]
Contains fulltext : 110439.pdf (Publisher’s version ) (Open Access)Being quick often comes at the expense of being accurate. This speed-accuracy tradeoff is a central feature of many types of decision making.
Jasper eWinkel +22 more
core +1 more source
Bromocriptine alters hormone rhythms and lipid metabolism in swine
Hormones, metabolites and activities involved in lipid synthesis were assayed in pigs made leaner by bromocriptine treatment. Market size female swine were allowed free access to food under natural lighting conditions and implanted with bromocriptine ...
Southern, L. L. +2 more
core +1 more source
Bromocriptine in type 2 diabetes mellitus
Bromocriptine mesylate quick-release was approved by the Food and Drug Administration (FDA) in May 2009, for the treatment of type 2 diabetes. Bromocriptine is thought to act on the circadian neuronal activities in the hypothalamus, to reset an ...
Sanjay Kalra, C Shivaprasad
core +1 more source
Bromocriptine Mesylate for Glycemic Management in Type 2 Diabetes Mellitus
Objective: To review the pharmacologic characteristics, safety, and efficacy of bromocriptine mesylate for glycemic control in patients with type 2 diabetes mellitus.
Katherine A Petkewicz +2 more
core +1 more source
Metabolite involvement in bromocriptine-induced circling behaviour in rodents
Bromocriptine and apomorphine produced identical circling responses in rodents with medial forebrain bundle lesions. Rotation induced by bromocriptine, but not by apomorphine, was inhibited by prior treatment with reserpine or α-methyl-p-tyrosine ...
C Reavill, C D Marsden, P Jenner
core +1 more source
Background & aim: The effect of drugs on different receptors causes the effect as well as side effects of the drug. For example, dopamine drugs, in addition to their anti-Parkinsonian effects, block the upper parts of the hypothalamic-pituitary-gonad ...
SH Rashidpour +2 more
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