Results 81 to 90 of about 32,807 (303)

Efficacy and safety of add on therapy of bromocriptine with metformin in Indian patients with type 2 diabetes mellitus: A randomized open labeled phase IV clinical trial

open access: yesIndian Journal of Pharmacology, 2014
Objective: To compare the effectiveness and safety of add on therapy of bromocriptine with metformin in type 2 diabetes mellitus (DM) patients. Material and Methods: Adult type 2 DM patients fulfilling the inclusion criteria were randomized in three ...
Arijit Ghosh   +5 more
semanticscholar   +1 more source

Loss of choroid plexus‐derived insulin‐like growth factor 2 (IGF2) leads to hyposmia, while retaining post‐partum mood resilience in mice

open access: yesJournal of Neuroendocrinology, Volume 37, Issue 9, September 2025.
Abstract During the post‐partum period, new mothers are vulnerable to mood disorders. In adults, impairments in neurogenesis commonly associate with anxiety and depressive behaviors. Insulin‐like growth factor 2 (IGF2) is expressed in the choroid plexus (CP) within the subventricular zone (SVZ) neurogenic niche, and global loss of IGF2 leads to ...
Hollian R. Phillipps   +4 more
wiley   +1 more source

Bromocriptine: A Sympatholytic, D2-Dopamine Agonist for the Treatment of Type 2 Diabetes

open access: yesDiabetes Care, 2011
Bromocriptine is a sympatholytic D2-dopamine agonist that has been approved for the treatment of type 2 diabetes. Based on animal and human studies, timed bromocriptine administration within 2 h of awakening is believed to augment low hypothalamic ...
R. DeFronzo
semanticscholar   +1 more source

Bilateral Adrenal Ablation for the Treatment of Ectopic ACTH Syndrome With Severe Hypokalemia: A Case Report and a Literature Review

open access: yesClinical Case Reports, Volume 13, Issue 8, August 2025.
ABSTRACT Ectopic ACTH secretion‐related Cushing's syndrome may manifest as a rapid onset of hypercortisolism, elevated urinary free cortisol (UFC) and blood ACTH concentrations, and hypokalemia. However, for patients whose primary lesions are difficult to remove, bilateral adrenalectomy is the recommended treatment method according to guidelines. Here,
Fang Sun   +6 more
wiley   +1 more source

A review of neuroleptic malignant syndrome : incidence and features in Malta [PDF]

open access: yes, 1995
This paper describes Malta’s first sample of Neuroleptic Malignant Syndrome (NMS) and reviews the current literature. A retrospective sample of all diagnosed cases of NMS was reviewed using Pope’s (1986) criteria. Twelve cases were identified yielding an
Grech, Anton, Saliba, Joseph R.
core  

Bromocriptine Does Not Alter Speed–Accuracy Tradeoff

open access: yesFrontiers in Neuroscience, 2012
Being quick often comes at the expense of being accurate. This speed–accuracy tradeoff is a central feature of many types of decision making. It has been proposed that dopamine plays an important role in adjusting responses between fast and accurate ...
J. Winkel   +6 more
semanticscholar   +1 more source

Mitochondria as Regulators of Nonapoptotic Cell Death in Cancer

open access: yesMedComm, Volume 6, Issue 8, August 2025.
Mitochondrial fission and fusion are key processes in maintaining cellular health. Fission is driven by proteins like, Fis‐1, which recruits DRP‐1, to facilitate the division of mitochondria. Fusion, however, is mediated by mitofusion 1(MFN1), mitofusion 2(MFN2), and optic atrophy 1 (OPA1), which work together to merge mitochondria, allowing functional
Saloni Malla   +8 more
wiley   +1 more source

Acromegaly: pathogenesis & treatment [PDF]

open access: yes, 2019
Acromegaly is a multi-system disorder whose etiology is most often traced back to a growth hormone-secreting pituitary adenoma (PA). Growth hormone (GH) secretion promotes insulin-like growth factor 1 (IGF-1) release from peripheral tissues, leading to ...
Tilvawala, Megha
core  

Advances in the treatment of prolactinomas [PDF]

open access: yes, 2006
Prolactinomas account for approximately 40% of all pituitary adenomas and are an important cause of hypogonadism and infertility. The ultimate goal of therapy for prolactinomas is restoration or achievement of eugonadism through the normalization of ...
1997 Data on file   +627 more
core   +1 more source

The Application of Polymeric Nanoparticles as Drug Delivery Carriers to Cells in Neurodegenerative Diseases

open access: yesCell Proliferation, Volume 58, Issue 8, August 2025.
Polymeric nanoparticles represent promising drug (gene) delivery carriers to the brain due to their unique advantages to facilitate the penetration of blood–brain barrier and endocytosis of neuronal cells in neurodegenerative diseases. ABSTRACT In spite of great advances in modern medicine, there are a few effective strategies for the treatment of ...
Lian Jin   +4 more
wiley   +1 more source

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