Results 101 to 110 of about 4,858 (185)
MedComm, Volume 7, Issue 3, March 2026.Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia +4 more
wiley +1 more source
Epigenetics & ChromatinBackground INO80 and SWR1 are evolutionarily related ATP-dependent chromatin remodeling complexes that regulate the chromatin occupancy of the histone variant H2A.Z, playing critical roles in transcriptional regulation, genome replication, and DNA repair.
Jyoti Garg +14 more
doaj +1 more source
Protein Lactylation in Cancer: Mechanisms and Therapeutic Targets
MedComm, Volume 7, Issue 3, March 2026.This schematic illustrates the central role of lactylation, a lactate‐derived posttranslational modification, in linking metabolic reprogramming to cancer progression and therapy resistance. At its core, lactylation modulates proteins, influenced by metabolic shifts and environmental factors.
Qianying Ouyang +10 more
wiley +1 more source
Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury
Med Research, Volume 2, Issue 1, Page 4-21, March 2026.ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang +13 more
wiley +1 more source
Results in ChemistryThe bromodomain and extra-terminal domain (BET) family of proteins has been implicated as a crucial factor in the pathogenesis of numerous diseases by regulating gene expression and chromatin dynamics through its bromodomains, which bind to acetylated ...
Linlin Deng +6 more
doaj +1 more source
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang +7 more
wiley +1 more source
Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic Applications
MedComm – Oncology, Volume 5, Issue 1, March 2026.Molecular glue degraders (MGDs) constitute an emerging class of therapeutic agents poised to revolutionize the paradigm of targeted drug discovery. By reprogramming E3 ubiquitin ligases to degrade proteins of interest (POI) via a transient formation of a ternary complex mediated by protein–protein interactions, MGDs surpass the intrinsic limitations of
Jinfeng Wen +3 more
wiley +1 more source
Breaking barriers: transitioning from X‐ray crystallography to cryo‐EM for structural studies
Acta Crystallographica Section D, Volume 82, Issue 3, Page 253-273, March 2026.This article describes the transition of the Glass laboratory from X‐ray crystallography to single‐particle cryo‐electron microscopy (cryo‐EM) for structural studies of ATAD2B, a large AAA+ ATPase‐ and bromodomain‐containing protein involved in chromatin regulation.
Hassan Zafar +4 more
wiley +1 more source
Testis specific gene expression drives disease progression and Rituximab resistance in lymphoma
EMBO Molecular Medicine, 2013 Stefan Knapp
doaj +1 more source