Results 1 to 10 of about 21,450 (117)
Targeting bromodomain and extraterminal proteins in cardiovascular disease: Pathological mechanisms and therapeutic applications [PDF]
Journal of International Medical ResearchBromodomain and extraterminal proteins have emerged as key epigenetic regulators that coordinate transcriptional programs fundamental to cardiovascular physiology and disease.
Kaixuan Zhang, Yangkai Fan, Yuan Wang
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Bromodomain dimers: A case study of BRD4 and family-wide AlphaFold predictions [PDF]
Structural DynamicsBromodomains are conserved acetyl-lysine reader domains that play a central role in the assembly of transcriptional regulatory complexes. While generally presumed to function as monomers, bromodomain homo-dimers have been identified, and several ...
Alisa S. Dengler +3 more
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Recent Progress and Prospect in Studying Selective Inhibitors Toward Bromodomain Family Members [PDF]
MoleculesBromodomain (BRD)-containing proteins are gaining attention as key targets in epigenetic drug development. BRDs bind to acetylated lysine residues on histones and other proteins, significantly impacting transcriptional regulation and chromatin remodeling.
Jianzhong Chen +3 more
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eLife, 2021 Human bromodomain and extra-terminal domain (BET) family members are promising targets for therapy of cancer and immunoinflammatory diseases, but their mechanisms of action and functional redundancies are poorly understood.
Rafal Donczew, Steven Hahn
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Exploration of Targeted Anti-tumor Therapy, 2021 Aim: Bromodomain and extra-terminal domain (BET) proteins are epigenetic readers that play a fundamental role in transcription regulation. Preclinical and early clinical evidence sustain BET targeting as an anti-cancer approach.
Chiara Tarantelli +14 more
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BET Bromodomain Inhibitors: Novel Design Strategies and Therapeutic Applications
Molecules, 2023 The mammalian bromodomain and extra-terminal domain (BET) family of proteins consists of four conserved members (Brd2, Brd3, Brd4, and Brdt) that regulate numerous cancer-related and immunity-associated genes.
Kenneth K. W. To +3 more
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The Aggregation of ATAD2 Bromodomain in Solution
Chinese Journal of Magnetic Resonance, 2023 ATPase family AAA domain-containing protein 2 (ATAD2) is a chromatin regulator, also known as an oncogenic transcription cofactor. Its abnormal expression is closely related to the occurrence and development of various malignant tumors. ATAD2 consists of
WANG Yuanfang +5 more
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A Nutrient-Based Cellular Model to Characterize Acetylation-Dependent Protein-Protein Interactions
Frontiers in Molecular Biosciences, 2022 Cellular homeostasis requires the orderly expression of thousands of transcripts. Gene expression is regulated by numerous proteins that recognize post-translational modifications—in particular, the acetylation of lysine residues (Kac) on histones.
Jérémy Loehr +15 more
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The Functions of BET Proteins in Gene Transcription of Biology and Diseases
Frontiers in Molecular Biosciences, 2021 The BET (bromodomain and extra-terminal domain) family proteins, consisting of BRD2, BRD3, BRD4, and testis-specific BRDT, are widely acknowledged as major transcriptional regulators in biology.
Ka Lung Cheung +2 more
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The BRPF1 bromodomain is a molecular reader of di-acetyllysine
Current Research in Structural Biology, 2020 Bromodomain-containing proteins are often part of chromatin-modifying complexes, and their activity can lead to altered expression of genes that drive cancer, inflammation and neurological disorders in humans.
Juliet O. Obi +10 more
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