Results 11 to 20 of about 33,428 (239)

Bromodomain Proteins in HIV Infection [PDF]

Viruses, 2013
Bromodomains are conserved protein modules of ~110 amino acids that bind acetylated lysine residues in histone and non-histone proteins. Bromodomains are present in many chromatin-associated transcriptional regulators and have been linked to diverse ...
Melanie Ott, Ott, Melanie, Daniela Boehm, Conrad, Ryan J, Boehm, D, Ryan J. Conrad, Boehm, Daniela, Conrad, RJ, Ryan Conrad   +8 more
core   +7 more sources

CBP/p300 bromodomain: new promising epigenetic target [PDF]

Visualized Cancer Medicine, 2022
CREB (cAMP responsive element binding protein) binding protein (CBP) and adenovirus E1A-associated 300 kDa protein (p300) are histone acetyltransferases, which are necessary for multiple cellular processes.
Xiang Qiuping, Zhou Yang, Zhang Yan, Xu Yong   +3 more
doaj   +3 more sources

Functional Roles of Bromodomain Proteins in Cancer

Cancers, 2021
Simple Summary This review provides an in depth analysis of the role of bromodomain-containing proteins in cancer development. As readers of acetylated lysine on nucleosomal histones, bromodomain proteins are poised to activate gene expression, and often
Samuel P. Boyson, Cong Gao, Kathleen H. Quinn, Joseph R. Boyd, H. Paculova, S. Frietze, K. Glass   +6 more
semanticscholar   +2 more sources

The BRPF1 bromodomain is a molecular reader of di-acetyllysine

Current Research in Structural Biology, 2020
Bromodomain-containing proteins are often part of chromatin-modifying complexes, and their activity can lead to altered expression of genes that drive cancer, inflammation and neurological disorders in humans.
Juliet O. Obi, Mulu Y. Lubula, Gabriel Cornilescu, Amy Henrickson, Kara McGuire, Chiara M. Evans, Margaret Phillips, Samuel P. Boyson, Borries Demeler, John L. Markley, Karen C. Glass   +10 more
doaj   +2 more sources

Bromodomain biology and drug discovery [PDF]

Nature Structural & Molecular Biology, 2019
The bromodomain (BrD) is a conserved structural module found in chromatin- and transcription-associated proteins that acts as the primary reader for acetylated lysine residues.
Nilesh Zaware, Ming‐Ming Zhou
semanticscholar   +3 more sources

Discovery of a PCAF bromodomain chemical probe [PDF]

Angewandte Chemie International Edition, 2016
The p300/CBP-associated factor (PCAF) and related GCN5 bromodomain-containing lysine acetyl transferases are members of subfamily I of the bromodomain phylogenetic tree.
Apirat Chaikuad, Mendez Johnson, Jacqui, Brennan, Paul E., Peter G. K. Clark, Yang, Hongbing, Catherine M. Rogers, TRULLI, LAURA, Mendez-Johnson, Jacqui, Dorrell, Lucy, Murphy, Emma J., Matthias T. Ehebauer, Ehebauer, Matthias T., John R. Walker, Dixon, Darren J, Daniels, Danette, Lin, Yu Hui, Dixon, Darren J., Huber, Kilian V.M., Chun‐Feng D. Hou, Dixon, Darren, Moses Moustakim, Clark, Peter G.K., Clark, Peter G. K., Hou, Chun-Feng D., Jacqui Mendez‐Johnson, Octovia P. Monteiro, Hui, Raymond, Kilian V. M. Huber, Jag Heer, Stefan Knapp, Hou, Chun Feng D., Fedorov, Oleg, Emma J. Murphy, Fuentes de Arriba, Angel L., Monteiro, Octovia, Oleg Fedorov, Heer, Jag, Laura Trulli, Knapp, Stefan, Rogers, Catherine M., Huber, Kilian, Yu‐Hui Lin, Danette Daniels, Paul E. Brennan, Lucy Dorrell, Moustakim, Moses, Darren J. Dixon, Brennan, Paul, Huber, Kilian V. M., Chaikuad, Apirat, Raymond Hui, Walker, John R., Angel L. Fuentes de Arriba, Monteiro, Octovia P., Lin, Yu-Hui, Hongbing Yang   +55 more
core   +7 more sources

Structure-Guided Design of a Domain-Selective Bromodomain and Extra Terminal N‑Terminal Bromodomain Chemical Probe [PDF]

, 2023
Small-molecule-mediated disruption of the protein–protein interactions between acetylated histone tails and the tandem bromodomains of the bromodomain and extra-terminal (BET) family of proteins is an important mechanism of action for the potential ...
Christopher R. Wellaway (7148462), Peter D. Craggs (7180412), Inmaculada Rioja (8539), Marc Reid (1695424), David S. Palmer (1328991), Ian D. Wall (2525425), Lucia Fusani (4578958), Emmanuel H. Demont (1399288), Rosa Cookson (2588734), Philip G. Humphreys (1357530), William J. Kerr (1267110), Erin Bradley (1436305), Alex Phillipou (8551068), Chun-wa Chung (1343454), Darren J. Mitchell (1343451), Rishi R. Shah (8232807), Rab K. Prinjha (449759)   +16 more
core   +4 more sources

Bromodomain: an acetyl-lysine binding domain [PDF]

FEBS Letters, 2002
Bromodomains, an extensive family of evolutionarily conserved protein modules originally found in proteins associated with chromatin and in nearly all nuclear histone acetyltransferases, have been recently discovered to function as acetyl-lysine binding ...
Ming-Ming Zhou, Zeng, Lei, Lei Zeng, Zhou, Ming-Ming   +3 more
core   +3 more sources

Immunogenicity of prostate cancer is augmented by BET bromodomain inhibition [PDF]

Journal for ImmunoTherapy of Cancer, 2019
Background Prostate cancer responds poorly to current immunotherapies. Epigenetic therapies such as BET Bromodomain inhibition can change the transcriptome of tumor cells, possibly making them more immunogenic and thus susceptible to immune targeting ...
Wendy Mao, Ali Ghasemzadeh, Zachary T. Freeman, Aleksandar Obradovic, Matthew G. Chaimowitz, Thomas R. Nirschl, Emily McKiernan, Srinivasan Yegnasubramanian, Charles G. Drake   +8 more
doaj   +2 more sources

A Minireview on BET Inhibitors: Beyond Bromodomain Targeting

Biomedicines
Bromodomain and extra-terminal domain (BET) proteins are epigenetic readers that recognize the histone acetylation code and play a critical role in regulating gene transcription.
Mikhail S. Iudin, Yuri M. Khodarovich, Anna M. Varizhuk, Vladimir B. Tsvetkov, Vyacheslav V. Severov   +4 more
doaj   +2 more sources