Results 41 to 50 of about 27,094 (219)

BRD4 (bromodomain containing 4) [PDF]

, 2007
Review on BRD4 (bromodomain containing 4), with data on DNA, on the protein encoded, and where the gene is ...
Collin, A
core   +1 more source

Functional Roles of Bromodomain Proteins in Cancer

, 2021
Histone acetylation is generally associated with an open chromatin configuration that facilitates many cellular processes including gene transcription, DNA repair, and DNA replication. Aberrant levels of histone lysine acetylation are associated with the
Joseph Boyd, Samuel P. Boyson, Karen C. Glass, Cong Gao, Hana Paculova, Seth Frietze, Kathleen Quinn   +6 more
core   +1 more source

Pro-Inflammatory Properties of Salivary Gland-Derived Fibroblasts—Implications in Sjögren’s Disease

Cells
Salivary gland dysfunction is a hallmark of Sjögren’s disease (SjD). Here, we investigated the pro-inflammatory properties of salivary gland-derived fibroblasts (SGF) that were cultured from minor salivary gland (MSG) tissues of patients with SjD and ...
Matthias Brunner, Daniel Guggisberg, Marco Sprecher, Ondrej Pastva, Kristina Bürki, Miranda Houtman, Marco Kreuzer, Sara Andrea Krättli, Laura Jahnke, Mila Roceri, Rémy Bruggmann, Muriel Elhai, Britta Maurer, Thomas M. Marti, Caroline Ospelt, Kerstin Klein   +15 more
doaj   +1 more source

Design and Synthesis of Hybrid Compounds as Epigenetic Modifiers

Pharmaceuticals, 2021
Epigenetic modifiers acting through polypharmacology mechanisms are promising compounds with which to treat several infectious diseases. Histone deacetylase (HDAC) enzymes, mainly class I, and extra-terminal bromodomains (BET) are involved in viral ...
Juliana Romano Lopes, Igor Muccilo Prokopczyk, Max Gerlack, Chung Man Chin, Jean Leandro Dos Santos   +4 more
doaj   +1 more source

Discovery of Highly Potent BET Inhibitors based on a Tractable Tricyclic Scaffold [PDF]

The bromodomain and extra-terminal domain (BET) protein family is a class of epigenetic reader proteins that recognize N-acetylated lysine residues in histone tails, playing a crucial role in gene expression and cell transcription.
Zaidi, Jaffer M., Stocks, Michael J., Chan, Weng C., Comeo, Eleonora, Baxter, Andrew, Preston, Alex G.S.   +5 more
core   +1 more source

Exploring the Histone Acetylation Cycle in the Protozoan Model Tetrahymena thermophila

Frontiers in Cell and Developmental Biology, 2020
The eukaryotic histone acetylation cycle is composed of three classes of proteins, histone acetyltransferases (HATs) that add acetyl groups to lysine amino acids, bromodomain (BRD) containing proteins that are one of the most characterized of several ...
Suzanne Wahab, Alejandro Saettone, Syed Nabeel-Shah, Nora Dannah, Jeffrey Fillingham   +4 more
doaj   +1 more source

Structural variation of protein-ligand complexes of the first bromodomain of BRD4 [PDF]

, 2021
The bromodomain-containing protein 4 (BRD4), a member of the bromodomain and extra-terminal domain (BET) family, plays a key role in several diseases, especially cancers.
Ellen, Guest, Guest, Ellen E., Stephen, Pickett, Pickett, Stephen D., Jonathan, Hirst, Hirst, Jonathan D.   +5 more
core   +5 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Should I Stay or Should I Go—Leveraging an Overlooked Feature of Click‐to‐Release Chemistry for Affinity Labeling

Angewandte Chemie, EarlyView.
Click‐to‐release (C2R) chemistry is redirected from payload liberation toward ligand‐directed covalent protein labeling through a transient dihydropyridazine methide (DHP‐methide). This concept opens the way to dual‐functional systems combining covalent target engagement with controlled effector release.
Dóra Kern, Krisztina Németh, Tímea Imre, József Simon, Kitti Meggyes, Gergő Bárdos, László Petri, Márton Bojtár, Attila Kormos, Péter Kele   +9 more
wiley   +2 more sources

Nucleosome conformation dictates the histone code

eLife
Histone post-translational modifications (PTMs) play a critical role in chromatin regulation. It has been proposed that these PTMs form localized ‘codes’ that are read by specialized regions (reader domains) in chromatin-associated proteins (CAPs) to ...
Matthew R Marunde, Harrison A Fuchs, Jonathan M Burg, Irina K Popova, Anup Vaidya, Nathan W Hall, Ellen N Weinzapfel, Matthew J Meiners, Rachel Watson, Zachary B Gillespie, Hailey F Taylor, Laylo Mukhsinova, Ugochi C Onuoha, Sarah A Howard, Katherine Novitzky, Eileen T McAnarney, Krzysztof Krajewski, Martis W Cowles, Marcus A Cheek, Zu-Wen Sun, Bryan J Venters, Michael-C Keogh, Catherine A Musselman   +22 more
doaj   +1 more source