Results 51 to 60 of about 33,428 (239)

Dual-target inhibitors of bromodomain and extra-terminal proteins in cancer: A review from medicinal chemistry perspectives

Medicinal research reviews (Print), 2021
Bromodomain‐containing protein 4 (BRD4), as the most studied member of the bromodomain and extra‐terminal (BET) family, is a chromatin reader protein interpreting epigenetic codes through binding to acetylated histones and non‐histone proteins, thereby ...
Lu Feng, Guan Wang, Yi Chen, Gu He, Bo Liu, Jie Liu, C. Chiang, Ouyang Liang   +7 more
semanticscholar   +1 more source

BRD3 (bromodomain containing 3) [PDF]

, 2016
BRD3 is a ubiquitously expressed member of the bromodomain and extraterminal motif (BET) family of proteins that use their tandem N-terminal bromodomains to associate with acetylated histones and transcription factors.
Blobel, Gerd A, Werner, Michael T, Hsu, Sarah C   +2 more
core   +1 more source

Spotlight on Plant Bromodomain Proteins

Biology, 2023
Bromodomain-containing proteins (BRD-proteins) are the “readers” of histone lysine acetylation, translating chromatin state into gene expression. They act alone or as components of larger complexes and exhibit diverse functions to regulate gene expression; they participate in chromatin remodeling complexes, mediate histone modifications, serve as ...
Eirini Bardani, Paraskevi Kallemi, Martha Tselika, Konstantina Katsarou, Kriton Kalantidis   +4 more
openaire   +3 more sources

Blocking the Bromodomains Function Contributes to Disturbances in Alga Chara vulgaris Spermatids Differentiation

Cells, 2020
Bromodomain containing (BRD) proteins play an essential role in many cellular processes. The aim of this study was to estimate activity of bromodomains during alga Chara vulgaris spermatids differentiation. The effect of a bromodomain inhibitor, JQ1 (100
Agnieszka Wojtczak
doaj   +1 more source

Selective inhibition of BET bromodomains [PDF]

Nature, 2010
Epigenetic proteins are intently pursued targets in ligand discovery. So far, successful efforts have been limited to chromatin modifying enzymes, or so-called epigenetic 'writers' and 'erasers'. Potent inhibitors of histone binding modules have not yet been described.
Filippakopoulos, P, Qi, J, Picaud, S, Shen, Y, Smith, W, Fedorov, O, Morse, E, Keates, T, Hickman, T, Felletar, I, Philpott, M, Munro, S, McKeown, M, Wang, Y, Christie, A, West, N, Cameron, M, Schwartz, B, Heightman, T, La Thangue, N, French, C, Wiest, O, Kung, A, Knapp, S, Bradner, J   +24 more
openaire   +4 more sources

Current Understanding of the Role of the Brd4 Protein in the Papillomavirus Lifecycle

Viruses, 2013
The Brd4 protein is an epigenetic reader that is central to regulation of cellular transcription and mitotic bookmarking. The transcription and replication proteins of many viruses interact with Brd4.
Moon Kyoo Jang, Alison A. McBride
doaj   +1 more source

Bromodomain and extra-terminal motif inhibitors: a review of preclinical and clinical advances in cancer therapy

Future Science OA, 2019
Histone lysine acetylation is critical in regulating transcription. Dysregulation of this process results in aberrant gene expression in various diseases, including cancer.
Ali J Alqahtani, Khalil Choucair, M. Ashraf, D. M. Hammouda, Abduraham Alloghbi, Talal Khan, N. Senzer, J. Nemunaitis   +7 more
semanticscholar   +1 more source

BRD4 (bromodomain containing 4) [PDF]

, 2007
Review on BRD4 (bromodomain containing 4), with data on DNA, on the protein encoded, and where the gene is ...
Collin, A
core   +1 more source

Engineered bromodomains to explore the acetylproteome [PDF]

PROTEOMICS, 2015
MS‐based analysis of the acetylproteome has highlighted a role for acetylation in a wide array of biological processes including gene regulation, metabolism, and cellular signaling. To date, anti‐acetyllysine antibodies have been used as the predominant affinity reagent for enrichment of acetyllysine‐containing peptides and proteins; however, these ...
Del Rosario, Amanda M, Yaffe, Michael B, Gootenberg, Jonathan S, Bryson, Bryan D., White, Forest M.   +4 more
openaire   +4 more sources

Pro-Inflammatory Properties of Salivary Gland-Derived Fibroblasts—Implications in Sjögren’s Disease

Cells
Salivary gland dysfunction is a hallmark of Sjögren’s disease (SjD). Here, we investigated the pro-inflammatory properties of salivary gland-derived fibroblasts (SGF) that were cultured from minor salivary gland (MSG) tissues of patients with SjD and ...
Matthias Brunner, Daniel Guggisberg, Marco Sprecher, Ondrej Pastva, Kristina Bürki, Miranda Houtman, Marco Kreuzer, Sara Andrea Krättli, Laura Jahnke, Mila Roceri, Rémy Bruggmann, Muriel Elhai, Britta Maurer, Thomas M. Marti, Caroline Ospelt, Kerstin Klein   +15 more
doaj   +1 more source