Results 161 to 170 of about 4,858 (185)

1,3,4-oxadiazoles as inhibitors of the atypical member of the BET family bromodomain factor 3 from Trypanosoma cruzi (TcBDF3). [PDF]

Front Microbiol
Alonso VL, Escalante AM, Rodríguez Araya E, Frattini G, Tavernelli LE, Moreno DM, Furlan RLE, Serra E.   +7 more
europepmc   +1 more source

Discovery of Monovalent Direct Degraders of BRD4 that Act via the Recruitment of DCAF11. [PDF]

Mol Cancer Ther
Parker GS, Toth JI, Fish S, Blanco G, Kampert T, Li X, Yang L, Stumpf CR, Steadman K, Jamborcic A, Chien S, Daniele E, Dearie A, Leriche G, Bailey S, Thompson PA.   +15 more
europepmc   +1 more source

Cancer-associated polybromo-1 bromodomain 4 missense variants variably impact bromodomain ligand binding and cell growth suppression. [PDF]

J Biol Chem
Bursch KL, Goetz CJ, Jiao G, Nuñez R, Olp MD, Dhiman A, Khurana M, Zimmermann MT, Urrutia RA, Dykhuizen EC, Smith BC.   +10 more
europepmc   +1 more source

Histone Acetyltransferases Gcn5 and Esa1 Regulate Occupancy of RSC to Maintain Nucleosome-Depleted Regions and Promote RSC Recruitment to Coding Regions Genome-Wide in <i>Saccharomyces cerevisiae</i>. [PDF]

Mol Cell Biol
Biernat E, Verma M, Werick M, Khan U, Joseph S, Govind CK.   +5 more
europepmc   +1 more source

A Review of the Bromodomain and Extraterminal Domain Epigenetic Reader Proteins: Function on Virus Infection and Cancer. [PDF]

Viruses
Wu M, Guan G, Yin H, Niu Q.
europepmc   +1 more source

Taf1 expression in mouse: novel transcripts and protein distribution

Li P, Cleverley K, Crombie EM, Bieschke J, Fisher EM, Brown A.   +5 more
europepmc   +1 more source

Peptide molecular glues select between BET paralogues by exploiting allosteric sites and conformational dynamics

Patel K, Mohanty B, Norman A, Franck C, Pachl P, Yang L, Jing X, Reid XJ, Walshe JL, Solomon P, Tran DH, Ford D, Low JKK, Wilkinson-White L, Passioura T, Payne RJ, Suga H, Walport LJ, Mackay JP.   +18 more
europepmc   +1 more source

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BET bromodomain inhibitors

Current Opinion in Chemical Biology, 2022
Lysine acetylation creates docking sites for epigenetic reader domains of BET bromodomain proteins that have emerged as principal regulators of linage specific gene transcription. The development of potent and highly selective inhibitors, that have been soon widely available, enabled mechanistic studies in a diversity of disease models leading to a ...
Martin P. Schwalm, Stefan Knapp
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Bromodomain and extraterminal domain protein bromodomain inhibitor based cancer therapeutics

Current Opinion in Oncology, 2021
Purpose of review Bromodomain and extraterminal domain (BET) proteins are evolutionarily conserved, multifunctional super-regulators that specifically recognize acetyl-lysine on histones and other proteins controlling gene transcription.
Tithi Ghosh, Halder, Raffaella, Soldi, Sunil, Sharma   +2 more
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Bromodomain inhibitors and therapeutic applications

Current Opinion in Chemical Biology, 2023
The bromodomain acts to recognize acetylated lysine in histones and transcription proteins and plays a fundamental role in chromatin-based cellular processes including gene transcription and chromatin remodeling. Many bromodomain proteins, particularly the bromodomain and extra terminal domain (BET) protein BRD4 have been implicated in cancers and ...
Bharath Kumar Gajjela, Ming-Ming Zhou
openaire   +2 more sources