Results 171 to 180 of about 252,536 (246)
Cochrane Evidence Synthesis and Methods, Volume 4, Issue 5, September 2026.ABSTRACT Introduction Artificial intelligence (AI) is a branch of technology enabling machines to emulate complex human skills; it can also entail problem‐solving using bioinspired methods. It is used for automating systematic literature reviews (SLR), that is, defining a clinical question, locating relevant literature, preliminary screening, study ...
Ana M. Barragán +5 more
wiley +1 more source
CCR2/CCR5 Signaling Defines a Pathogenic Interstitial Macrophage Subset That Drives Severe Asthma
Clinical and Translational Allergy, Volume 16, Issue 9, September 2026.In mouse model of severe asthma, protective resident alveolar macrophages are depleted and replaced by monocyte‐derived populations, particularly a Lyve1loMHCIIhi interstitial macrophage subset enriched for Ccr2/Ccr5 and inflammatory gene programs. Blocking this subset with a dual CCR2/CCR5 antagonist reduces airway inflammation, restores homeostasis ...
Hao Wang +8 more
wiley +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.Cisplatin induces oxidative stress and hepatotoxicity, as evidenced by increased serum biomarkers and oxidative damage parameters. Luteolin, derived from Pistacia terebinthus, mitigates these effects by enhancing antioxidant defense systems and improving cell viability in cancer cell lines.
Özge Temiz +9 more
wiley +1 more source
Tissue‐Resident Macrophage in Inflammation and Cancer
MedComm, Volume 7, Issue 9, September 2026.Opposing macrophage functions in inflammation and cancer converge on shared mechanistic nodes, informing cross‐disease therapeutic strategies. ABSTRACT Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological ...
Siyuan Huang +13 more
wiley +1 more source
New Zealand Journal of Botany, Volume 64, Issue 3, September 2026.Introduction: Cardiotoxicity is an undesirable side effect of chemotherapy that limits the effectiveness of cancer treatment. Almost all cardiotoxic agents cause cardiovascular complications, leading to oxidative stress and other pathological conditions.
Susanna Badalyan +2 more
wiley +1 more source
Pediatric Functional Lung Imaging: A Scoping Review
Pediatric Pulmonology, Volume 61, Issue 9, September 2026.ABSTRACT Functional lung imaging enables pulmonary parameters, including ventilation, perfusion, gas exchange, and biomechanics, to be mapped and quantified noninvasively throughout the lungs. Pulmonary function testing is generally more difficult to perform in a child in comparison to an adult, and so pulmonary functional imaging has the potential to ...
Matthew Bruorton +9 more
wiley +1 more source
Allergy, Volume 81, Issue 9, Page 3039-3070, September 2026.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
Franziska Roth‐Walter +20 more
wiley +1 more source
Nasal Airway Transcriptome Reflects Selected Asthma‐Associated Gene Signatures in the Lower Airways
Allergy, Volume 81, Issue 9, Page 3197-3205, September 2026.Seven genes and two gene modules were consistently associated with asthma in both airway compartments in ARMS and were validated in ATLANTIS. The two modules reflected IL‐13 related inflammation and mast cell activity, respectively. Nasal gene signatures provide a non‐invasive proxy for selected bronchial asthma‐associated gene signatures. ARMS, Asthma
Hui Wen +22 more
wiley +1 more source
Allergy, Volume 81, Issue 9, Page 3221-3235, September 2026.This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake +8 more
wiley +1 more source
Allergy, Volume 81, Issue 9, Page 3345-3360, September 2026.Studies suggest that type 2 inflammatory diseases are driven by overactivation of the IL4/IL13 pathway, manifesting differently in distinct tissues. We performed quantitative analyses using several large independent datasets to explore the interrelation of type 2 inflammatory diseases based on co‐prevalence, genetic predispositions, and transcriptomic ...
Jennifer D. Hamilton +19 more
wiley +1 more source