Results 1 to 10 of about 325,759 (119)

Severe asthma in children: Evaluation and management

Allergology International, 2019
Severe asthma in children is associated with significant morbidity. Children with severe asthma are at increased risk for adverse outcomes including medication-related side effects, life-threatening exacerbations, and impaired quality of life.
Mehtap Haktanir Abul, Wanda Phipatanakul
doaj   +3 more sources

Assessing adherence to inhaled therapies in asthma and the emergence of electronic monitoring devices

European Respiratory Review, 2022
Infrequent use of inhaled corticosteroids (ICS) and/or over-reliance of short-acting β-agonists (SABA) are recognised as key contributors to increased morbidity and mortality in asthma.
Hetal Dhruve, David J. Jackson
doaj   +1 more source

A patient case demonstrating the efficacy of benralizumab in uncontrolled severe eosinophilic asthma refractory to omalizumab and mepolizumab treatment

Respiratory Medicine Case Reports, 2021
Severe eosinophilic asthma is associated with a heavy burden and impact on daily living in patients experiencing uncontrolled symptoms, exacerbations, and treatment side effects.
John Davison, Simon Doe
doaj   +1 more source

Associations of symptoms of anxiety and depression with health-status, asthma control, dyspnoea, dysfunction breathing and obesity in people with severe asthma

Respiratory Research, 2022
Background Anxiety and depression are comorbidities of severe asthma. However, clinical characteristics associated with coexisting severe asthma and anxiety/depression are poorly understood.
Michelle A. Stubbs, Vanessa L. Clark, Peter G. Gibson, Janelle Yorke, Vanessa M. McDonald   +4 more
doaj   +1 more source

A feasibility randomised controlled trial of Novel Activity Management in severe ASthma-Tailored Exercise (NAMASTE): yoga and mindfulness

BMC Pulmonary Medicine, 2021
Background Physical inactivity is common in severe asthma and associated with poor health outcomes. New approaches are needed to address physical inactivity in this group.
Sarah A. Hiles, Paola D. Urroz, Peter G. Gibson, Adam Bogdanovs, Vanessa M. McDonald   +4 more
doaj   +1 more source

Phenotype overlap in the natural history of asthma

European Respiratory Review, 2023
The heterogeneity of asthma makes it challenging to unravel the pathophysiologic mechanisms of the disease. Despite the wealth of research identifying diverse phenotypes, many gaps still remain in our knowledge of the disease's complexity.
Fabio L.M. Ricciardolo, Giuseppe Guida, Francesca Bertolini, Antonino Di Stefano, Vitina Carriero   +4 more
doaj   +1 more source

What matters to people with severe asthma? Exploring add-on asthma medication and outcomes of importance

ERJ Open Research, 2021
There is an increasing number of new therapies for severe asthma; however, what outcomes people with severe asthma would like improved and what aspects they prioritise in new medications remain unknown.
Vanessa L. Clark, Peter G. Gibson, Vanessa M. McDonald   +2 more
doaj   +1 more source

“It's like being on a roller coaster”: the burden of caring for people with severe asthma

ERJ Open Research, 2021
Introduction Family carers and significant others play a fundamental role in the well-being of people with severe asthma. This study aimed to investigate the challenges faced by family carers/significant others of people with severe asthma, to understand
Eleanor C. Majellano, Vanessa L. Clark, Juliet M. Foster, Peter G. Gibson, Vanessa M. McDonald   +4 more
doaj   +1 more source

Difficult‐to‐treat asthma patients from ethnic minority groups in central England are at an enhanced risk of house dust mite sensitisation

Clinical and Translational Allergy, 2023
Background House dust mite (HDM) is the most common sensitising allergen in asthma. Ethnic minority groups (EMGs) in the UK are more likely to live in deprived conditionings with a greater exposure to HDM and other aero‐allergens.
Adel H. Mansur, Julie Marsh, Ali Bahron, Maximillian Thomas, Gareth Walters, John Busby, Liam G. Heaney, Mamidipudi Thirumala Krishna   +7 more
doaj   +1 more source

Dupilumab modulates specific IgE mite responses at the molecular level in severe T2-high atopic dermatitis: A real-world experience

Frontiers in Medicine, 2022
BackgroundAtopic dermatitis (AD) is regarded as a chronic systemic disease which is characterized by a robust overexpression of type 2 related cytokines, with increased total IgE levels and a concomitant sensitization to common allergens.
Ruperto González-Pérez, Ruperto González-Pérez, Paloma Poza-Guedes, Paloma Poza-Guedes, Elena Mederos-Luis, Inmaculada Sánchez-Machín   +5 more
doaj   +1 more source