Results 1 to 10 of about 23,541 (163)

Biomarkers for severe eosinophilic asthma [PDF]

Journal of Allergy and Clinical Immunology, 2017
The last decade has seen the approval of several new biologics for the treatment of severe asthma-targeting specific endotypes and phenotypes. This review will examine how evidence generated from the mepolizumab clinical development program showed that blood eosinophil counts, rather than sputum or tissue eosinophil counts, evolved as a pharmacodynamic
Frank Albers, Hector Ortega, Ian Pavord   +2 more
exaly   +4 more sources

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma [PDF]

New England Journal of Medicine, 2014
Some patients with severe asthma have frequent exacerbations associated with persistent eosinophilic inflammation despite continuous treatment with high-dose inhaled glucocorticoids with or without oral glucocorticoids.In this randomized, double-blind, double-dummy study, we assigned 576 patients with recurrent asthma exacerbations and evidence of ...
Guy Brusselle, Alfredo Chetta, Hector Ortega   +2 more
exaly   +5 more sources

Eosinophilic bioactivities in severe asthma [PDF]

World Allergy Organization Journal, 2016
Asthma is clearly related to airway or blood eosinophilia, and asthmatics with significant eosinophilia are at higher risk for more severe disease. Eosinophils actively contribute to innate and adaptive immune responses and inflammatory cascades through ...
Tara F. Carr, Sergejs Berdnikovs, Hans-Uwe Simon, Bruce S. Bochner, Lanny J. Rosenwasser   +4 more
doaj   +4 more sources

Efficacy of Benralizumab in Reducing FeNO in Severe Eosinophilic Asthma: The Role of CRSwNP [PDF]

Journal of Asthma and Allergy
Juan Luis Garcia-Rivero,1,2 Beatriz Abascal-Bolado,1 Nieves Aranda Sobrino,2 Cristina Ghadban Garrido2 1Respiratory Department, Marqués de Valdecilla University Hospital, Santander, Spain; 2Valdecilla Research Institute (IDIVAL), Santander ...
Garcia-Rivero JL, Abascal-Bolado B, Aranda Sobrino N, Ghadban Garrido C   +3 more
doaj   +2 more sources

Mepolizumab treatment alters the functional phenotype of eosinophils in severe eosinophilic asthma. [PDF]

Front Immunol
Background Blood eosinophil count is usually employed as a predictive and response biomarker for mepolizumab treatment. However, its decrease is not always associated with an improvement in asthma symptoms.
Miguéns-Suárez P, Martelo-Vidal L, Vázquez-Mera S, Blanco-Aparicio M, Calvo-Álvarez U, González-Fernández C, Mosteiro-Añón M, Corbacho-Abelaira D, Hermida-Valverde T, Calvo-Henríquez C, Nieto-Fontarigo JJ, Salgado FJ, González-Barcala FJ.   +12 more
europepmc   +3 more sources

Construction of Severe Eosinophilic Asthma Related Competing Endogenous RNA Network by Weighted Gene Co-Expression Network Analysis

Frontiers in Pharmacology, 2022
Background: Currently, disease control in patients with severe eosinophilic asthma is not optimistic. Competing endogenous RNA (ceRNA) networks have been found to play a key role in asthma in recent years.
Haixia Wang, Zeyi Zhang, Yu Ma, Yuanmin Jia, Bin Ma, Junlian Gu, Ou Chen, Ou Chen, Shouwei Yue, Shouwei Yue   +9 more
doaj   +1 more source

Two years follow-up of relapsing eosinophilic pneumonia with concomitant severe asthma successfully treated with benralizumab: A case report and brief review of the literature

Respiratory Medicine Case Reports, 2023
Relapsing eosinophilic pneumonia and severe eosinophilic asthma are rare and disabling diseases, which share common inflammatory backgrounds and often require long-term systemic steroid therapy.
G. Angeletti, M. Mazzolini, A. Rocca
doaj   +1 more source

Severe eosinophilic asthma [PDF]

European respiratory journal, 2017
A task force has identified key consensus issues for defining, diagnosing and treating severe eosinophilic asthmahttp://ow.ly ...
Buhl, Roland, Humbert, Marc, Bjermer, Leif, Chanez, Pascal, Heaney, Liam G., Pavord, Ian, Quirce, Santiago, Virchow, Johann C., Holgate, Stephen, Djukanovic, Ratko, Chung, Kian Fan, Canonica, Walter, Papi, Alberto, Brightling, Chris, Horváth, Ildiko, Walker, Samantha, Brusselle, Guy, Backer, Vibeke, Kuna, Piotr, Bel, Elisabeth, De Llano, Luis Perez, Rabe, Klaus   +21 more
openaire   +5 more sources

Severe Eosinophilic Asthma [PDF]

Journal of Clinical Medicine, 2019
Asthma is a heterogeneous disease with varying severity. Severe asthma is a subject of constant research because it greatly affects patients’ quality of life, and patients with severe asthma experience symptoms, exacerbations, and medication side effects.
Bakakos, A., Loukides, S., Bakakos, P.
openaire   +3 more sources

Eosinophilic inflammation: An Appealing Target for Pharmacologic Treatments in Severe Asthma

Biomedicines, 2022
Severe asthma is characterized by different endotypes driven by complex pathologic mechanisms. In most patients with both allergic and non-allergic asthma, predominant eosinophilic airway inflammation is present.
Alessandro Vatrella, Angelantonio Maglio, Corrado Pelaia, Luigi Ciampo, Giulia Pelaia, Carolina Vitale   +5 more
doaj   +1 more source