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Biomarkers for severe eosinophilic asthma [PDF]

Journal of Allergy and Clinical Immunology, 2017
The last decade has seen the approval of several new biologics for the treatment of severe asthma-targeting specific endotypes and phenotypes. This review will examine how evidence generated from the mepolizumab clinical development program showed that blood eosinophil counts, rather than sputum or tissue eosinophil counts, evolved as a pharmacodynamic
Yancey, S, Keene, O, Albers, F, Ortega, H, Bates, S, Bleecker, E, Pavord, I   +6 more
openaire   +5 more sources

Eosinophilic bioactivities in severe asthma [PDF]

World Allergy Organization Journal, 2016
Asthma is clearly related to airway or blood eosinophilia, and asthmatics with significant eosinophilia are at higher risk for more severe disease. Eosinophils actively contribute to innate and adaptive immune responses and inflammatory cascades through ...
Tara F. Carr, Sergejs Berdnikovs, Hans-Uwe Simon, Bruce S. Bochner, Lanny J. Rosenwasser   +4 more
doaj   +4 more sources

Efficacy of Benralizumab in Reducing FeNO in Severe Eosinophilic Asthma: The Role of CRSwNP [PDF]

Journal of Asthma and Allergy
Juan Luis Garcia-Rivero,1,2 Beatriz Abascal-Bolado,1 Nieves Aranda Sobrino,2 Cristina Ghadban Garrido2 1Respiratory Department, Marqués de Valdecilla University Hospital, Santander, Spain; 2Valdecilla Research Institute (IDIVAL), Santander ...
Garcia-Rivero JL, Abascal-Bolado B, Aranda Sobrino N, Ghadban Garrido C   +3 more
doaj   +2 more sources

Construction of Severe Eosinophilic Asthma Related Competing Endogenous RNA Network by Weighted Gene Co-Expression Network Analysis

Frontiers in Pharmacology, 2022
Background: Currently, disease control in patients with severe eosinophilic asthma is not optimistic. Competing endogenous RNA (ceRNA) networks have been found to play a key role in asthma in recent years.
Haixia Wang, Zeyi Zhang, Yu Ma, Yuanmin Jia, Bin Ma, Junlian Gu, Ou Chen, Ou Chen, Shouwei Yue, Shouwei Yue   +9 more
doaj   +1 more source

Two years follow-up of relapsing eosinophilic pneumonia with concomitant severe asthma successfully treated with benralizumab: A case report and brief review of the literature

Respiratory Medicine Case Reports, 2023
Relapsing eosinophilic pneumonia and severe eosinophilic asthma are rare and disabling diseases, which share common inflammatory backgrounds and often require long-term systemic steroid therapy.
G. Angeletti, M. Mazzolini, A. Rocca
doaj   +1 more source

Severe Eosinophilic Asthma [PDF]

Journal of Clinical Medicine, 2019
Asthma is a heterogeneous disease with varying severity. Severe asthma is a subject of constant research because it greatly affects patients’ quality of life, and patients with severe asthma experience symptoms, exacerbations, and medication side effects.
Bakakos, A., Loukides, S., Bakakos, P.
openaire   +3 more sources

Eosinophilic inflammation: An Appealing Target for Pharmacologic Treatments in Severe Asthma

Biomedicines, 2022
Severe asthma is characterized by different endotypes driven by complex pathologic mechanisms. In most patients with both allergic and non-allergic asthma, predominant eosinophilic airway inflammation is present.
Alessandro Vatrella, Angelantonio Maglio, Corrado Pelaia, Luigi Ciampo, Giulia Pelaia, Carolina Vitale   +5 more
doaj   +1 more source

Experience with mepolizumab in adults with severe eosinophilic asthma: a case series from India

Respirology Case Reports, 2021
Severe asthma can be associated with eosinophilic or allergic phenotypes or both. Eosinophilic inflammation is associated with exacerbations and disease severity due to biological activity of interleukin‐5 (IL‐5).
Venkata Nagarjuna Maturu, Priti Meshram, Soumya Das, Ashok Kumar Rajput, Arun Chowdary Kotaru, Bhavesh Kotak, Neeraj Markandeywar, Simran Chhatwal   +7 more
doaj   +1 more source

Identifying clinical and demographic characteristic differences between eosinophilic and non-eosinophilic asthma and detecting predictors of eosinophilic asthma among Egyptian asthmatic patients

The Egyptian Journal of Bronchology, 2022
Introduction Asthma is a heterogenous disease with various phenotypes that is characterized by airway limitation due to bronchospasm and airway inflammation associated with excessive mucus secretion.
Maged Mohamed Refaat, Riham Hazem Raafat, Heba Eid AbuAlia, Dina Sayed Sheha   +3 more
doaj   +1 more source

Neutrophils and Asthma

Diagnostics, 2022
Although eosinophilic inflammation is characteristic of asthma pathogenesis, neutrophilic inflammation is also marked, and eosinophils and neutrophils can coexist in some cases. Based on the proportion of sputum cell differentiation, asthma is classified
Akira Yamasaki, Ryota Okazaki, Tomoya Harada   +2 more
doaj   +1 more source