Results 11 to 20 of about 1,917,601 (292)
Severe Eosinophilic Asthma [PDF]
Journal of Clinical Medicine, 2019 Asthma is a heterogeneous disease with varying severity. Severe asthma is a subject of constant research because it greatly affects patients’ quality of life, and patients with severe asthma experience symptoms, exacerbations, and medication side effects.
Bakakos, A., Loukides, S., Bakakos, P.
core +5 more sources
Severe eosinophilic asthma [PDF]
European respiratory journal, 2017 A task force has identified key consensus issues for defining, diagnosing and treating severe eosinophilic asthmahttp://ow.ly ...
Buhl, Roland +21 more
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Severe eosinophilic bronchial asthma: new therapeutic options [PDF]
Медицинский совет, 2018 Eosinophilic asthma is a common phenotype of severe asthma, occurring in at least half of patients. In recent years, there have been significant changes in the approaches to the treatment of severe bronchial asthma and, above all, eosinophilic asthma ...
N. M. Nenasheva
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Mepolizumab in the Treatment of Severe Eosinophilic Asthma
Immunotherapy, 2015 IL-5 is crucial in the pathogenesis and evolution of eosinophilic asthma. Mepolizumab is a high-affinity humanized monoclonal antibody of the IgG1/k subtype that inhibits the binding of IL-5 to its receptor expressed on eosinophils, thereby inducing significant reduction in eosinophil circulation, as well as asthma exacerbations and corticosteroid ...
FAINARDI, Valentina +2 more
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Clinical usefulness of mepolizumab in severe eosinophilic asthma
Therapeutics and Clinical Risk Management, 2016 Asthma is a chronic inflammatory disorder of the airways with variable clinical severity from very mild and occasional symptoms to recurrent critical exacerbations, at risk of fatal or near-fatal outcome, in a small percentage of patients. Within the different inflammatory cascades involved in asthma, eosinophils play a central role in the pathogenesis
Menzella,Francesco +5 more
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Eosinophilic bioactivities in severe asthma [PDF]
World Allergy Organization Journal, 2016 Asthma is clearly related to airway or blood eosinophilia, and asthmatics with significant eosinophilia are at higher risk for more severe disease. Eosinophils actively contribute to innate and adaptive immune responses and inflammatory cascades through ...
Tara F. Carr +4 more
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Severe eosinophilic asthma: from the pathogenic role of interleukin-5 to the therapeutic action of mepolizumab [PDF]
Drug Design, Development and Therapy, 2017 Corrado Pelaia,1 Alessandro Vatrella,2 Maria Teresa Busceti,1 Luca Gallelli,3 Rosa Terracciano,3 Rocco Savino,3 Girolamo Pelaia1 1Department of Medical and Surgical Sciences, Section of Respiratory Diseases, University “Magna Græcia&rdquo ...
Pelaia C +6 more
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Eosinophilic Asthma: Pathophysiology and Therapeutic Horizons
CellsAsthma is a prevalent chronic non-communicable disease, affecting approximately 300 million people worldwide. It is characterized by significant airway inflammation, hyperresponsiveness, obstruction, and remodeling.
Musaddique Hussain, Gang Liu
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New therapy options for patients with eosinophilic type of severe bronchial asthma [PDF]
Медицинский совет, 2020 The article provides data on the epidemiology of severe asthma. It defines the phenotype and endotype of bronchial asthma and classifies BA according to phenotype/endotype.
G. L. Ignatova +4 more
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Cellular Mechanisms Underlying Eosinophilic and Neutrophilic Airway Inflammation in Asthma
Mediators of Inflammation, 2015 Asthma is a phenotypically heterogeneous chronic disease of the airways, characterized by either predominant eosinophilic or neutrophilic, or even mixed eosinophilic/neutrophilic inflammatory patterns. Eosinophilic inflammation can be associated with the
Girolamo Pelaia +6 more
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