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Eosinophilic Asthma: Pathophysiology and Therapeutic Horizons

Cells
Asthma is a prevalent chronic non-communicable disease, affecting approximately 300 million people worldwide. It is characterized by significant airway inflammation, hyperresponsiveness, obstruction, and remodeling.
Musaddique Hussain, Gang Liu
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Immunological phenotype in asthma and its impact on long-term renal outcomes

Scientific Reports
Asthma is associated with both airway and systemic inflammation as well as non-respiratory adverse outcomes. However, data regarding its impact on long-term renal outcomes is lacking.
Wang Chung Kwok, Terence Chi Chun Tam, James Chung Man Ho, David Chi Leung Lam, Isaac Sze Him Leung, Mary Sau Man Ip, Desmond Yat Hin Yap   +6 more
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Neutrophilic asthma: current prospects. A review

Consilium Medicum
Asthma, caused by eosinophilic inflammation of the airways, is caused by exposure to allergen, is well treated with glucocorticostroids or monoclonal antibodies to interleukin-4 and 5, but some patients do not develop an answer to this therapy. The given
Viliya V. Gaynitdinova, Zamira M. Merzhoeva, Alena A. Aleksandrova   +2 more
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Differential Analysis of Hemogram Parameters and Cellular Ratios in Severe Asthma Exacerbations: A Comparative Study of Eosinophilic and Non-Eosinophilic Phenotypes

Life
Asthma exacerbations are acute worsening episodes in individuals with bronchial asthma, frequently necessitating emergency hospital care. Early differentiation between eosinophilic (≥150 eosinophils/mm3) and non-eosinophilic (
Nicolae Demenciuc, Corina Eugenia Budin, Corina Ureche, Mircea Stoian, Teodora Nicola-Varo, Dragos-Florin Baba, Dariana-Elena Pătrîntașu, Diana Deleanu   +7 more
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Effects of in vitro azithromycin treatment on bronchial epithelial antiviral immunity in asthma phenotypes

Frontiers in Allergy
BackgroundAzithromycin (AZM) effectively reduces asthma exacerbations and enhances bronchial epithelial cell (BEC) antiviral immunity in vitro. However, its clinical impact on different asthma phenotypes is not fully elucidated and differences in ...
Muzhda Ghanizada, Sofia Malm Tillgren, Louis Praeger-Jahnsen, Nihaya Mahmoud Said, Sisse Ditlev, Helle Frost Andreassen, Nanna Dyhre-Petersen, Samuel Cerps, Asger Sverrild, Celeste Porsbjerg, Lena Uller, Therese Lapperre, Therese Lapperre, Therese Lapperre, Mandy Menzel   +14 more
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Differences in Type 2 Phenotype and Clinical Characteristics of Adult Asthma Patients with Different Severity, Across GINA Step 1 to 5 Asthma

Journal of Asthma and Allergy
Wang Chun Kwok, Julie Kwan Ling Wang, Terence Chi Chun Tam, James Chung Man Ho, David Chi Leung Lam, Mary Sau Man Ip Department of Medicine, the University of Hong Kong, Hong Kong, SAR, People’s Republic of ChinaCorrespondence: Mary Sau Man Ip ...
Kwok WC, Wang JKL, Tam TCC, Ho JCM, Lam DCL, Ip MSM   +5 more
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When sequential use of mepolizumab and dupilumab in a severe atopic eosinophilic asthmatic questions the role of eosinophils in mediating the clinical expression of the disease: a case report

Journal of Medical Case Reports
Background The advent of biologics has resulted in major progress in the treatment of severe T2 high asthmatics. There are currently several classes of biologics approved for severe asthma including anti-immunoglobulin E, anti-interleukin-5/interleukin ...
M. Sabbe, F. Schleich, P. Janssens, R. Louis   +3 more
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CD11b Expression Level Measurement to Distinguish Asthma Phenotype in Pediatric Patients

Avicenna Journal of Medicine
Background Inflammation is involved in asthma pathogenesis. Based on the majority of inflammatory cells found in blood samples, asthma is divided into neutrophilic and eosinophilic phenotype.
Tien Budi Febriani, Soeroyo Mahfudz, Emi Azmi Choironi, Ninda Devita, Adika Zhulhi Arjana, Muhammad Nur Imansyah   +5 more
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Allergens abrogate antiinflammatory DNA effects and unmask macrophage-driven neutrophilic asthma via ILC2/STING/TNF-α signaling

The Journal of Clinical Investigation
The mechanisms of neutrophilic and mixed neutrophilic-eosinophilic asthma are poorly understood. We found that extracellular DNA and nucleosomes (Nucs) were elevated in the airways of patients with neutrophilic-eosinophilic asthma and correlated with ...
Anand Sripada, Divya Verma, Rangati Varma, Kapil Sirohi, Carolyn Kwiat, Mohini Pathria, Mukesh Verma, Anita Sahu, Vamsi Guntur, Laurie Manka, Brian Vestal, Camille Moore, Richard J. Martin, Magdalena M. Gorska, John Cambier, Andrew Getahun, Rafeul Alam   +16 more
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Eosinophillic myocarditis and coronary arteritis in a fatal case of asthma

Indian Journal of Pathology and Microbiology, 2010
Mortality is very unusual in the case of asthma. We recently came across a fatal case of asthma which showed a rare combination of unusual complications like eosinophilic myocarditis, coronary arteritis, biventricular cardiac hypertrophy, eosinophilic ...
Rupani Asha, Amonkar Gayathri, Deshpande Jaya   +2 more
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