Eosinophilic inflammation: An Appealing Target for Pharmacologic Treatments in Severe Asthma
Biomedicines, 2022 Severe asthma is characterized by different endotypes driven by complex pathologic mechanisms. In most patients with both allergic and non-allergic asthma, predominant eosinophilic airway inflammation is present.
Alessandro Vatrella +5 more
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Experience with mepolizumab in adults with severe eosinophilic asthma: a case series from India
Respirology Case Reports, 2021 Severe asthma can be associated with eosinophilic or allergic phenotypes or both. Eosinophilic inflammation is associated with exacerbations and disease severity due to biological activity of interleukin‐5 (IL‐5).
Venkata Nagarjuna Maturu +7 more
doaj +1 more source
A Case of Eosinophilic Gastroenteritis Remission Achieved Steroid-Free With Mepolizumab
Gastro Hep Advances, 2022 Eosinophilic gastroenteritis is an eosinophilic inflammatory disease that responds well to steroids but often relapses upon their discontinuation, necessitating maintenance treatment.
Yuki Hirata +2 more
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Targeting Eosinophils in Asthma [PDF]
Current Molecular Medicine, 2008 Recruitment of eosinophils has long been recognized as a hallmark of the inflammatory response in asthma. However, the functions of this population of cells in host defense remain poorly understood. Eosinophils play an important part in the inflammatory response and have key regulatory roles in the afferent arm of the immune response.
Foster, Paul S. +3 more
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Profile of reslizumab in eosinophilic disease and its potential in the treatment of poorly controlled eosinophilic asthma [PDF]
, 2013 Peer ...
Walsh, Garry Michael, Walsh GM
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Severe eosinophilic asthma and aspirin-exacerbated respiratory disease associated to eosinophilic gastroenteritis treated with mepolizumab: a case report [PDF]
, 2020 Background: Mepolizumab (MEP) is the first anti Interleukin (IL)-5 add-on therapy approved for the treatment of severe refractory eosinophilic asthma.
C. Di Mario +11 more
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Clinical characteristics of eosinophilic COPD versus COPD patients with a history of asthma
Respiratory Research, 2017 Eosinophilic COPD appears to be a distinct patient subgroup with an increased corticosteroid response. Eosinophilic COPD has been labelled as part of the asthma COPD overlap syndrome (ACOS).
Umme Kolsum +5 more
doaj +1 more source
Fasting impairs type 2 helper T cell infiltration in the lung of an eosinophilic asthma mouse model
FEBS Open Bio, 2021 Eosinophilic asthma is a form of bronchial asthma that is caused by the pulmonary infiltration of eosinophils and accounts for approximately half of the patients with severe asthma.
Yusuke Suzuki +7 more
doaj +1 more source
Eosinophilic Inflammation in Allergic Asthma [PDF]
Frontiers in Pharmacology, 2013 Eosinophils are circulating granulocytes involved in pathogenesis of asthma. A cascade of processes directed by Th2 cytokine producing T-cells influence the recruitment of eosinophils into the lungs. Furthermore, multiple elements including interleukin (IL)-5, IL-13, chemoattractants such as eotaxin, Clara cells, and CC chemokine receptor (CCR)3 are ...
Possa, Samantha S. +4 more
openaire +3 more sources
A community study of factors related to poorly controlled asthma among Brazilian urban children. [PDF]
, 2012 BACKGROUND: Asthma constitutes a serious public health problem in many regions of the world, including the city of Salvador, State of Bahia-Brazil. The purpose of this study was to analyse the factors associated with poor asthma control.
Cruz, Alvaro A. +30 more
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