Results 1 to 10 of about 123,808 (307)

Socioeconomic and regional influences on eosinophilic inflammation in chronic rhinosinusitis with nasal polyps [PDF]

World Allergy Organization Journal
Background: Eosinophilic inflammation is a key feature of chronic rhinosinusitis with nasal polyps (CRSwNP); however, the extent to which peripheral blood eosinophil counts reflect local nasal eosinophilia remains controversial, particularly across ...
Hao-Sheng Ni, MD, Li-Yuan Zhang, MD, Han-Qiang Lu, MD, Zhi-Cun Zhang, MD, Min Zhang, MD, Mei-Ping Lu, MD, PhD, Lei Cheng, MD, PhD   +6 more
doaj   +2 more sources

Identification of COPD Inflammatory Endotypes Using Repeated Sputum Eosinophil Counts

Biomedicines, 2022
Higher blood and sputum eosinophil counts are associated with a greater response to corticosteroids in COPD. Low blood eosinophil counts exhibit greater stability over time whereas higher counts demonstrate more variability.
Augusta Beech, Natalie Jackson, Dave Singh   +2 more
doaj   +1 more source

Targeted ablation of miR-21 decreases murine eosinophil progenitor cell growth. [PDF]

PLoS ONE, 2013
MiR-21 is one of the most up-regulated miRNAs in multiple allergic diseases associated with eosinophilia and has been shown to positively correlate with eosinophil levels.
Thomas X Lu, Eun-Jin Lim, Svetlana Itskovich, John A Besse, Andrew J Plassard, Melissa K Mingler, Joelle A Rothenberg, Patricia C Fulkerson, Bruce J Aronow, Marc E Rothenberg   +9 more
doaj   +1 more source

Haematological Predictors of Section Recovery in Dengue Cases [PDF]

National Journal of Laboratory Medicine, 2019
Introduction: Dengue fever is associated with relative increase in haemoglobin, haematocrit and monocyte counts and reduction in platelet counts, eosinophil percentage and absolute eosinophil count.
Sushma Nayar, B Sriranjan, Priyadarshini Shanmugam   +2 more
doaj   +1 more source

Clinical and Biological Markers in Hypereosinophilic Syndromes

Frontiers in Medicine, 2017
Hypereosinophilic syndromes (HES) are rare, heterogeneous syndromes characterized by markedly elevated eosinophil counts in the blood and/or tissue and evidence of eosinophil-associated pathology. Although parasitic infections, drug hypersensitivity, and
Paneez Khoury, Michelle Makiya, Amy D. Klion   +2 more
doaj   +1 more source

Nasal eosinophilia and eosinophil peroxidase in children and adolescents with rhinitis [PDF]

Korean Journal of Pediatrics, 2019
Background Researchers have shown that eosinophil peroxidase (EPO) is a relatively accurate marker of eosinophilia and eosinophil activity. However, its use as a marker of eosinophilic inflammation in nasal secretions is limited because the diagnostic ...
Yeonu Choi, Haeun Jeon, Eun Ae Yang, Jong-Seo Yoon, Hyun Hee Kim   +4 more
doaj   +1 more source

Recent advances in understanding eosinophil biology [version 1; referees: 2 approved]

F1000Research, 2017
With the advent of novel therapies targeting eosinophils, there has been renewed interest in understanding the basic biology of this unique cell. In this context, murine models and human studies have continued to highlight the role of the eosinophil in ...
Amy Klion
doaj   +1 more source

Transcription Factors in Eosinophil Development and As Therapeutic Targets

Frontiers in Medicine, 2017
Dynamic gene expression is a major regulatory mechanism that directs hematopoietic cell fate and differentiation, including eosinophil lineage commitment and eosinophil differentiation. Though GATA-1 is well established as a critical transcription factor
Patricia C. Fulkerson
doaj   +1 more source

Elevated eosinophil level predicted long time to next treatment in relapsed or refractory myeloma patients treated with lenalidomide

Cancer Medicine, 2020
Lenalidomide is an immunomodulatory drug that is administered commonly in patients with relapsed or refractory multiple myeloma (RRMM). Eosinophils have immunological functions, for instance, in allergic diseases and asthma. The purpose of this study was
Kazuhito Suzuki, Kaichi Nishiwaki, Tadahiro Gunji, Mitsuji Katori, Hidekazu Masuoka, Shingo Yano   +5 more
doaj   +1 more source

CD3−CD4+ lymphoid variant of hypereosinophilic syndrome: nodal and extranodal histopathological and immunophenotypic features of a peripheral indolent clonal T-cell lymphoproliferative disorder

Haematologica, 2015
The CD3−CD4+ lymphoid variant of hypereosinophilic syndrome is characterized by hypereosinophilia and clonal circulating CD3−CD4+ T cells. Peripheral T-cell lymphoma has been described during this disease course, and we observed in our cohort of 23 ...
Guillaume Lefèvre, Marie-Christine Copin, Christophe Roumier, Hélène Aubert, Martine Avenel-Audran, Nathalie Grardel, Stéphanie Poulain, Delphine Staumont-Sallé, Julien Seneschal, Gilles Salles, Kamel Ghomari, Louis Terriou, Christian Leclech, Chafika Morati-Hafsaoui, Franck Morschhauser, Olivier Lambotte, Félix Ackerman, Jacques Trauet, Sandrine Geffroy, Florent Dumezy, Monique Capron, Catherine Roche-Lestienne, Alain Taieb, Pierre-Yves Hatron, Sylvain Dubucquoi, Eric Hachulla, Lionel Prin, Myriam Labalette, David Launay, Claude Preudhomme, Jean-Emmanuel Kahn   +30 more
doaj   +1 more source