Transcription Factors in Eosinophil Development and As Therapeutic Targets
Frontiers in Medicine, 2017 Dynamic gene expression is a major regulatory mechanism that directs hematopoietic cell fate and differentiation, including eosinophil lineage commitment and eosinophil differentiation. Though GATA-1 is well established as a critical transcription factor
Fulkerson Patricia C
exaly +3 more sources
Circulating eosinophils in patients with hypereosinophilic syndrome have heterogeneous immunophenotypes [PDF]
Journal of Allergy and Clinical Immunology: GlobalBackground: Hypereosinophilic syndromes (HES) encompass a heterogeneous group of disorders characterized by blood and/or tissue hypereosinophilia. Despite recent advances, the diagnosis and management of HES remain challenging due to the lack of well ...
Krishan D. Chhiba, MD, PhD +6 more
doaj +2 more sources
Static and Dynamic Eosinophil Measures and In-Hospital Mortality in Patients with Sepsis: A Retrospective Cohort Study [PDF]
MedicinaBackgroundand Objectives: Reliable prognostic biomarkers in sepsis that are inexpensive and universally available remain limited. Eosinophil counts decrease in systemic illness, but the prognostic value of static versus dynamic eosinophil measures in ...
Florentina Mușat +6 more
doaj +2 more sources
Identification of COPD Inflammatory Endotypes Using Repeated Sputum Eosinophil Counts
Biomedicines, 2022 Higher blood and sputum eosinophil counts are associated with a greater response to corticosteroids in COPD. Low blood eosinophil counts exhibit greater stability over time whereas higher counts demonstrate more variability.
Augusta Beech +2 more
doaj +1 more source
Haematological Predictors of Section Recovery in Dengue Cases [PDF]
National Journal of Laboratory Medicine, 2019 Introduction: Dengue fever is associated with relative increase in haemoglobin, haematocrit and monocyte counts and reduction in platelet counts, eosinophil percentage and absolute eosinophil count.
Sushma Nayar +2 more
doaj +1 more source
Targeted ablation of miR-21 decreases murine eosinophil progenitor cell growth. [PDF]
PLoS ONE, 2013 MiR-21 is one of the most up-regulated miRNAs in multiple allergic diseases associated with eosinophilia and has been shown to positively correlate with eosinophil levels.
Thomas X Lu +9 more
doaj +1 more source
Clinical and Biological Markers in Hypereosinophilic Syndromes
Frontiers in Medicine, 2017 Hypereosinophilic syndromes (HES) are rare, heterogeneous syndromes characterized by markedly elevated eosinophil counts in the blood and/or tissue and evidence of eosinophil-associated pathology. Although parasitic infections, drug hypersensitivity, and
Paneez Khoury +2 more
doaj +1 more source
Nasal eosinophilia and eosinophil peroxidase in children and adolescents with rhinitis [PDF]
Korean Journal of Pediatrics, 2019 Background Researchers have shown that eosinophil peroxidase (EPO) is a relatively accurate marker of eosinophilia and eosinophil activity. However, its use as a marker of eosinophilic inflammation in nasal secretions is limited because the diagnostic ...
Yeonu Choi +4 more
doaj +1 more source
Clinical Microbiology Reviews, 2012 SUMMARY This review starts with discussions of several infectious causes of eosinophilic pneumonia, which are almost exclusively parasitic in nature. Pulmonary infections due specifically to Ascaris , hookworms, Strongyloides , Paragonimus , filariasis, and
Akuthota, P., Weller, Peter
openaire +4 more sources
Recent advances in understanding eosinophil biology [version 1; referees: 2 approved]
F1000Research, 2017 With the advent of novel therapies targeting eosinophils, there has been renewed interest in understanding the basic biology of this unique cell. In this context, murine models and human studies have continued to highlight the role of the eosinophil in ...
Amy Klion
doaj +1 more source