Results 1 to 10 of about 237,523 (354)

Eosinophil Knockout Humans: Uncovering the Role of Eosinophils Through Eosinophil-Directed Biological Therapies

Annual Review of Immunology, 2021
The enigmatic eosinophil has emerged as an exciting component of the immune system, involved in a plethora of homeostatic and inflammatory responses. Substantial progress has been achieved through experimental systems manipulating eosinophils in vivo ...
Elizabeth A Jacobsen, David J Jackson, Enrico Heffler   +2 more
exaly   +2 more sources

Type 2 innate lymphoid cells control eosinophil homeostasis

Nature, 2013
Eosinophils are specialized myeloid cells associated with allergy and helminth infections. Blood eosinophils demonstrate circadian cycling, as described over 80 years ago, and are abundant in the healthy gastrointestinal tract.
Steven J Van Dyken, Jakob von Moltke, Ari B Molofsky   +2 more
exaly   +2 more sources

Effect of Dupilumab on Blood Eosinophil Counts in Patients With Asthma, Chronic Rhinosinusitis With Nasal Polyps, Atopic Dermatitis, or Eosinophilic Esophagitis.

Journal of Allergy and Clinical Immunology: In Practice, 2022
BACKGROUND Transient increases in blood eosinophil counts have been observed in dupilumab clinical trials. OBJECTIVE Assessment of eosinophil counts and eosinophilia-related treatment-emergent adverse events (TEAEs) across 11 dupilumab clinical trials,
M. Wechsler, A. Klion, P. Paggiaro, Parameswaran Nair, Delphine Staumont-Sallé, A. Radwan, Robert R. Johnson, U. Kapoor, F. A. Khokhar, N. Daizadeh, Zhen Chen, E. Laws, B. Ortiz, J. Jacob-Nara, L. Mannent, P. Rowe, Y. Deniz   +16 more
semanticscholar   +1 more source

Identification of COPD Inflammatory Endotypes Using Repeated Sputum Eosinophil Counts

Biomedicines, 2022
Higher blood and sputum eosinophil counts are associated with a greater response to corticosteroids in COPD. Low blood eosinophil counts exhibit greater stability over time whereas higher counts demonstrate more variability.
Augusta Beech, Natalie Jackson, Dave Singh   +2 more
doaj   +1 more source

Blood eosinophil count and prospective annual asthma disease burden: a UK cohort study

Lancet Respiratory Medicine,the, 2015
David B Price, Eugene R Bleecker, Mike Thomas   +2 more
exaly   +2 more sources

Haematological Predictors of Section Recovery in Dengue Cases [PDF]

National Journal of Laboratory Medicine, 2019
Introduction: Dengue fever is associated with relative increase in haemoglobin, haematocrit and monocyte counts and reduction in platelet counts, eosinophil percentage and absolute eosinophil count.
Sushma Nayar, B Sriranjan, Priyadarshini Shanmugam   +2 more
doaj   +1 more source

Patients of COVID-19 may benefit from sustained Lopinavir-combined regimen and the increase of Eosinophil may predict the outcome of COVID-19 progression

International Journal of Infectious Diseases, 2020
Highlights • An asymptomatic 2019-coronavirus disease patient with normal radiography throughout appeared in this study.• Lopinavir has a positive effect on 2019-coronavirus disease patients.• Eosinophil counts presented potentiality as a predictor on ...
Fang Liu, A. Xu, Yan Zhang, Weiling Xuan, Ting-bo Yan, Kenv Pan, Wenyan Yu, Jun Zhang   +7 more
semanticscholar   +1 more source

Eosinophil responses during COVID-19 infections and coronavirus vaccination

Journal of Allergy and Clinical Immunology, 2020
Eosinophils are circulating and tissue-resident leukocytes that have potent pro-inflammatory effects in a number of diseases. Recently, eosinophils have been shown to have a variety of other functions, including immunoregulation and antiviral activity ...
Andrew W. Lindsley, Justin T. Schwartz, Marc E. Rothenberg   +2 more
semanticscholar   +1 more source

Targeted ablation of miR-21 decreases murine eosinophil progenitor cell growth. [PDF]

PLoS ONE, 2013
MiR-21 is one of the most up-regulated miRNAs in multiple allergic diseases associated with eosinophilia and has been shown to positively correlate with eosinophil levels.
Thomas X Lu, Eun-Jin Lim, Svetlana Itskovich, John A Besse, Andrew J Plassard, Melissa K Mingler, Joelle A Rothenberg, Patricia C Fulkerson, Bruce J Aronow, Marc E Rothenberg   +9 more
doaj   +1 more source

Blood eosinophil count in the general population: typical values and potential confounders

European Respiratory Journal, 2020
There is growing interest in blood eosinophil counts in the management of chronic respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD).
S. Hartl, M. Breyer, O. Burghuber, A. Ofenheimer, A. Schrott, M. Urban, A. Agustí, M. Studnicka, E. Wouters, R. Breyer-Kohansal   +9 more
semanticscholar   +1 more source