Results 31 to 40 of about 123,808 (307)

mTOR complexes differentially orchestrates eosinophil development in allergy

Scientific Reports, 2018
Eosinophil infiltration is considered a hallmark in allergic airway inflammation, and the blockade of eosinophil differentiation may be an effective approach for treating eosinophil-related disorders.
Chen Zhu, Lixia Xia, Fei Li, Lingren Zhou, Qingyu Weng, Zhouyang Li, Yinfang Wu, Yuanyuan Mao, Chao Zhang, Yanping Wu, Miao Li, Songmin Ying, Zhihua Chen, Huahao Shen, Wen Li   +14 more
doaj   +1 more source

Natural killer cells induce eosinophil activation and apoptosis.

PLoS ONE, 2014
Eosinophils are potent inflammatory cells with numerous immune functions, including antigen presentation and exacerbation of inflammatory responses through their capacity to release a range of largely preformed cytokines and lipid mediators. Thus, timely
Ali Awad, Hanane Yassine, Mathieu Barrier, Han Vorng, Philippe Marquillies, Anne Tsicopoulos, Catherine Duez   +6 more
doaj   +1 more source

Novel targeted therapies for eosinophil-associated diseases and allergy. [PDF]

, 2015
Eosinophil-associated diseases often present with life-threatening manifestations and/or chronic organ damage. Currently available therapeutic options are limited to a few drugs that often have to be prescribed on a lifelong basis to keep eosinophil ...
Simon, Hans-Uwe, Michael E. Wechsler, Peter Valent, Hans-Uwe Simon, Valent, Peter, Wechsler, Michael E, Susanne Radonjic-Hoesli, Amy D. Klion, Radonjic-Hoesli, Susanne, Klion, Amy D, Wechsler ME, Klion AD, Simon HU, Radonjic-Hoesli S, Valent P   +14 more
core   +1 more source

Circulating eosinophils in patients with hypereosinophilic syndrome have heterogeneous immunophenotypes

Journal of Allergy and Clinical Immunology: Global
Background: Hypereosinophilic syndromes (HES) encompass a heterogeneous group of disorders characterized by blood and/or tissue hypereosinophilia. Despite recent advances, the diagnosis and management of HES remain challenging due to the lack of well ...
Krishan D. Chhiba, MD, PhD, Richard Kasjanski, MS, Michelle A. Makiya, MS, Thomas Brown, BSN, CCRP, Paneez Khoury, MD, Amy D. Klion, MD, Fei Li Kuang, MD, PhD   +6 more
doaj   +1 more source

Evaluation of exacerbations and blood eosinophils in UK and US COPD populations

Respiratory Research, 2019
Background Blood eosinophil counts and history of exacerbations have been proposed as predictors of patients with chronic obstructive pulmonary disease (COPD) who may benefit from triple therapy (inhaled corticosteroid, long-acting β2-agonist and long ...
Claus F. Vogelmeier, Konstantinos Kostikas, Juanzhi Fang, Hengfeng Tian, Bethan Jones, Christopher Ll Morgan, Robert Fogel, Florian S. Gutzwiller, Hui Cao   +8 more
doaj   +1 more source

Peripheral blood eosinophil and classification of residual hematoma help predict the recurrence of chronic subdural hematoma after initial surgery

Frontiers in Surgery, 2022
Chronic subdural hematoma (CSDH) is a common type of intracranial hemorrhage in neurosurgical practice, whose incidence has increased markedly in recent years. However, CSDH still troubles clinicians with a high postoperative recurrence rate.
Sichao Chen, Linqian Shao, Li Ma
doaj   +1 more source

Inhalation Toxicity of Coal Fly Ash in Mice Models [PDF]

Asia Pacific Journal of Medical Toxicology, 2020
Background: Indonesia is one of world’s largest producers of coal. Coal fly ash (CFA), a product of the coal combustion process, consists of various minerals and causes toxic effects by inhalation.
Dewita Putri, Latifatu Choirunisa, Isa Ansori   +2 more
doaj   +1 more source

Eosinophils and eosinophil-associated diseases: An update [PDF]

Journal of Allergy and Clinical Immunology, 2018
The goal of this series is to offer a survey of the latest literature for clinicians and scientists alike, providing a list of important recent advances relevant to the broad field of allergy and immunology. This particular assignment was to cover the topic of eosinophils. In an attempt to highlight major ideas, themes, trends, and advances relevant to
Jeremy A. O'Sullivan, Bruce S. Bochner
openaire   +2 more sources

Increased serum levels of eosinophil cationic protein and eosinophil-derived neurotoxin (protein X) in vernal keratoconjunctivitis

, 1994
To evaluate whether the eosinophil preformed mediators, eosinophil cationic protein X, and eosinophil-derived neurotoxin/eosinophil protein X (EDN/EPX) are detectable in serum and can be used as markers of eosinophilic ...
Tomassini, M, Stefano Bonini, Bonini, S, Alessandro Lambiase, Sergio Bonini, LAMBIASE, ALESSANDRO, Magrini, L, Margherita Tomassini, Bonini, S., Laura Magrini   +9 more
core   +1 more source

Race and Household Income Are Associated With Disease Outcomes in Pediatric Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Hospitalized in the United States

Arthritis Care &Research, EarlyView.
Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos, William Daniel Soulsby III, Emily von Scheven   +2 more
wiley   +1 more source