Results 31 to 40 of about 232,012 (210)

Association of asthma genetic variants with asthma-associated traits reveals molecular pathways of eosinophilic asthma [PDF]

, 2023
Introduction Asthma is a complex, polygenic, heterogenous inflammatory disease. Recently, we generated a list of 128 independent single nucleotide polymorphisms (SNPs) associated with asthma in genome-wide association studies.
El-Husseini, Zaid W., Koppelman, Gerard H., Gosens, Reinoud, Maarten van den Berge, Koppelman, Gerard H.; id_orcid, Reinoud Gosens, Judith M. Vonk, van den Berge, Maarten; id_orcid, Gerard H. Koppelman, van den Berge, Maarten, Vonk, Judith M., Zaid W. El‐Husseini, El-Husseini, Zaid W.; id_orcid   +12 more
core   +2 more sources

Risk factors for asthma and allergy associated with urban migration: background and methodology of a cross-sectional study in Afro-Ecuadorian school children in Northeastern Ecuador (Esmeraldas-SCAALA Study). [PDF]

, 2006
BACKGROUND: Asthma and allergic diseases are becoming increasingly frequent in children in urban centres of Latin America although the prevalence of allergic disease is still low in rural areas.
Cooper Philip J, Bernd Genser, Stein, RT, de Carvalho, Lain Pontes, Pontes-de-Carvalho, Lain Carlos, Cooper, Philip J, Rodriguez, Alejandro, Chico Martha E, Rodrigues, LC, Alejandro Rodriguez, Chico, ME, Vaca, Maritza G, Barreto, Maurício Lima, Alcântara-Neves, Neuza M, Martinez, Gioconda Maritza Vaca, Rodriguez Alejandro, Maritza G Vaca, Cruz Alvaro A, Martha E Chico, Stein Renato T, Laura C Rodrigues, Genser, Bernd, Rodrigues, Laura C, Cooper, PJ, Renato T Stein, Barreto, Mauricio L, Alcântara-Neves, NM, Stein, Renato Tetelbom, Stein, Renato T, Cruz, Alvaro A, Rodriguez, A, Vaca, MG, Alcântara-Neves Neuza M, de Carvalho Lain, Lain Pontes de Carvalho, Chico, Martha E, Genser, B, Genser Bernd, Vaca Maritza G, Alvaro A Cruz, Cooper, Philip John, Neves, Neuza Maria Alcântara, Rodrigues Laura C, Cruz, AA, de Carvalho, LP, Philip J Cooper, Barreto, ML, Mauricio L Barreto, Barreto Mauricio L, Neuza M Alcântara-Neves, Rodrigues, Laura Cunha, Cruz Filho, Alvaro Augusto Souza da   +51 more
core   +2 more sources

Targeting eosinophils: severe asthma and beyond

Drugs in Context, 2019
Recent research in the field of bronchial asthma has mainly focused on eosinophilic disease phenotype. Several trials proved the efficacy and safety profile of eosinophils and interleukin (IL)-5 targeting molecules, currently approved for severe asthma ...
Marco, Francesco, Lucia, Gianenrico
doaj   +1 more source

Conducting retrospective impact analysis to inform a medical research charity’s funding strategies: The case of Asthma UK [PDF]

, 2013
© 2013 Hanney et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Amanda Watt, Teresa H Jones, Jones, TH, Hanney, S, Metcalf, L, Stephen R Hanney, Leanne Metcalf, Watt, A   +7 more
core   +1 more source

Successful treatment with dupilumab for mucus plugs in severe asthma

Respirology Case Reports, 2023
A 29‐year‐old man presented to our hospital with severe eosinophilic asthma. He needed a short OCS burst for exacerbation of asthma once every 1 or 2 months, although he used a high dose of inhaled corticosteroids and a long‐acting beta‐2 agonists. Chest
Moriyasu Anai, Chieko Yoshida, Hiroki Izumi, Kei Muramoto, Koichi Saruwatari, Yusuke Tomita, Hidenori Ichiyasu, Takuro Sakagami   +7 more
doaj   +1 more source

Airway wall remodeling in asthma : novel mechanisms of human bronchial smooth muscle cells in the induction of angiogenesis [PDF]

, 2014
Asthma is a global major health concern and it affects estimated 300 million people. The prevalence of asthma is rising and there is no cure for asthma, only the symptoms can be controlled.
Keglowich, Laura Franziska
core   +1 more source

Eosinophil Apoptosis and Clearance in Asthma [PDF]

, 2013
Peer ...
Garry M. Walsh, Walsh, Garry M
core   +1 more source

Personalized and Precision Medicine in Asthma and Eosinophilic Esophagitis: The Role of T2 Target Therapy

Pharmaceutics, 2023
The role of type 2 inflammation has been progressively associated with many diseases, including severe asthma, atopic dermatitis, nasal polyposis, eosinophilic granulomatosis with polyangiitis, and, recently, eosinophilic esophagitis.
Diego Bagnasco, Edoardo Vincenzo Savarino, Mona-Rita Yacoub, Fulvio Braido, Maria Giulia Candeliere, Edoardo Giannini, Giovanni Passalacqua, Elisa Marabotto   +7 more
doaj   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Serum and Nasal Lavage Fluid Eosinophil‐Derived Neurotoxin Levels in Clinically Defined Asthma Phenotypes

Clinical and Translational Allergy
Background As a surrogate for eosinophilic activation, eosinophil‐derived neurotoxin (EDN) is a potential clinical biomarker. However, EDN levels and discriminatory ability in different asthma phenotypes are unknown.
Saliha Selin Özuygur Ermis, Carina Malmhäll, Magnus P. Borres, Robert Movérare, Daniil Lisik, Reshed Abohalaka, Selin Ercan, Susanne Schmeisser, Rani Basna, Roxana Mincheva, Göran Wennergren, Jan Lötvall, Linda Ekerljung, Madeleine Rådinger, Hannu Kankaanranta, Bright I. Nwaru   +15 more
doaj   +1 more source