Results 51 to 60 of about 36,390 (302)

Dosing Interval Extension of Dupilumab in CRSwNP: Five‐Year Real World Outcomes

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a persistent, often Type 2‐mediated inflammatory disease that markedly impairs quality of life. While dupilumab provides rapid improvement, there is limited evidence on long‐term outcomes beyond 2 years, and the clinical impact of dosing‐interval extension remains unclear.
Nicholas J. Campion, Dioni‐Pinelopi Petsiou, Florian C. Fally, Karina Berbalk, Noah F. Melamed, Aldine Tu, Christina Morgenstern, Fana Alem Kidane, Mohammed Zghaebi, Linda Liu, Minghao Pan, Tina J. Bartosik, Victoria Stanek, Katarina Gangl, Julia Eckl‐Dorna, Sven Schneider   +15 more
wiley   +1 more source

Determinação do componente inflamatório das doenças das vias aéreas através do escarro induzido: utilização na prática clínica [PDF]

, 2007
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-graduação em Ciências MédicasIntrodução: Além de um importante instrumento de pesquisa, a celularidade do escarro induzido (EI) vem sendo ...
Moritz, Pablo
core  

Antagonism of cytokine-induced eosinophil accumulation in asthma [PDF]

, 2012
Peer ...
Garry M Walsh, Garry M. Walsh, Walsh, Garry M.   +2 more
core   +1 more source

Allergic Rhinitis Amplifies Asthma Risk in Patients With Chronic Rhinosinusitis: A Large‐Scale Retrospective Cohort Analysis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) are two highly prevalent airway diseases in the United States. While the coexistence of CRS and asthma is well recognized, less is known about the development of new‐onset asthma in CRS, particularly in the context of comorbid AR. This study assessed the impact of CRS and AR on
Austin J. Lee, Mohamad R. Chaaban
wiley   +1 more source

Severe eosinophilic asthma: a roadmap to consensus.

, 2017
Asthma is widely accepted as a complex heterogeneous condition with diverse pathophysiological mechanisms, clinical presentations, comorbidities, physiological characteristics, pathology and outcomes that is typically best managed by a multidisciplinary ...
Expert Group of the European Consensus Meeting for Severe Eosinophilic Asthma, Humbert, M, Heaney, LG, Holgate, S, Bjermer, L, Pavord, Ian, Chanez, P, Quirce, S, Buhl, R, Pavord, I, Virchow, JC   +10 more
core   +1 more source

Effectiveness of mepolizumab in patients with severe eosinophilic asthma: results from real-world clinical practice in Finland [PDF]

, 2022
Objectives: Mepolizumab treatment provides clinical benefits for patients with severe eosinophilic asthma in randomized controlled trials. However, real-world data for patients in Finland are lacking.Methods: This retrospective, non-interventional, chart
Iso-Mustajarvi Ilona, Mehtala Juha, Viinanen Arja, Koistinen Ville, Kauppi Paula, Veijalainen Lauri, Kilpeläinen Maritta, Idänpään-Heikkilä Juhana, Ylisaukko-Oja Tero   +8 more
core   +1 more source

Interspecies Biofilm Dynamics Among Staphylococci: Inflammatory Contributions to Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Introduction Staphylococcus species are frequently isolated from the sinonasal niche of chronic rhinosinusitis (CRS) patients. While Staphylococcus aureus is often associated with recalcitrant CRS, Staphylococcus epidermidis and Staphylococcus lugdunensis are largely deemed commensal.
Sintayehu Ambachew, Mahnaz Ramezanpour, Clare M. Cooksley, Sholeh Feizi, Muhammed Awad, Kevin Aaron Fenix, Peter‐John Wormald, Alkis J. Psaltis, Sarah Vreugde   +8 more
wiley   +1 more source

Interleukin-13 in Asthma and Other Eosinophilic Disorders

Frontiers in Medicine, 2017
Asthma is characterized by episodic, reversible airflow obstruction associated with variable levels of inflammation. Over the past several decades, there has been an increasing appreciation that the clinical presentation of asthma comprises a diverse set
Emma Doran, Fang Cai, Cécile T. J. Holweg, Kit Wong, Jochen Brumm, Joseph R. Arron   +5 more
doaj   +1 more source

Evaluation of serum levels of interleukin-10 and transforming growth factor-β1 among Egyptian children with wheezy asthma phenotype

Egyptian Journal of Chest Disease and Tuberculosis, 2021
Background Asthma is known to be a heterogeneous disease that forms a problem in asthma management. Symptom-based asthma phenotyping with endotyping of the proposed phenotype is a trial to solve this problem.
Magdy M.E Zedan, Mohamed M Zedan, Afaf M El-Said, Ahmed M.H Badran, Yahya Wahba   +4 more
doaj   +1 more source

Extent of Sinus Surgery Is Associated With Disease Control in Biologic Treated Type 2 Dominant CRS

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background A greater benefit of biologics is observed after surgery in Type 2 chronic rhinosinusitis with nasal polyps (CRSwNP). However, the extent of surgery remains undefined in many studies. This study evaluated the extent of surgery on disease control in patients receiving biologics for refractory Type 2 dominant CRSwNP.
Nicholas J. Campion, Peta‐Lee Sacks, Lu Hui Png, Ruoxin Hua, Rhea Darbari Kaul, Raquel Alvarado, Christine Choy, Raymond Sacks, Peter Earls, Raewyn G. Campbell, Larry Kalish, Richard J. Harvey   +11 more
wiley   +1 more source