Results 61 to 70 of about 36,390 (302)

Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyp (CRSwNP) is a heterogeneous Type 2 inflammatory disease characterized by enhanced eosinophilic infiltration. Both innate and adaptive immunity are involved in the onset and progression of CRSwNP.
Yuki Sonoda, Yohei Sato, Yoshimasa Imoto, Mayumi Tamari, Shigeharu Fujieda   +4 more
wiley   +1 more source

Lonicerin attenuates house dust mite-induced eosinophilic asthma through targeting Src/EGFR signaling

Frontiers in Pharmacology, 2022
Eosinophilic asthma is the predominant phenotype of asthma, and although these patients are sensitive to glucocorticoid therapy, they also experience many side effects.
Zhenan Deng, Xuefei Zhang, Junjie Wen, Xiaojing Yang, Lingna Xue, Changxing Ou, Jianjuan Ma, Hongrui Zhan, Xiaomin Cen, Xuliang Cai, Yu Zhang, Riken Chen, Qingling Zhang   +12 more
doaj   +1 more source

Assessing Surgical Extent in Endoscopic Sinus Surgery: A Scoping Review of Scoring Systems

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Endoscopic sinus surgery (ESS) varies substantially in the extent of surgical dissection performed, even when described under the same procedural label. In chronic rhinosinusitis, this heterogeneity may influence postoperative outcomes, revision rates, and response to biologic therapies.
Alexander Lein, Marie T. Ehrgott, Linda Liu, Archana Jaiswal, Rajiv K. Bhalla, Noel Ayoub, Faris F. Brkic, David T. Liu   +7 more
wiley   +1 more source

Management of Severe Asthma in Eosinophilic Granulomatosis with Polyangiitis with Interleukin-5-Targeted Therapies: Current Status and Report of Two Cases

Applied Sciences, 2022
Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic disorder characterized by peripheral eosinophilia, severe eosinophilic asthma, sinusitis, transient pulmonary infiltrates, and features of medium/small-vessel vasculitis.
Ciro Romano, Domenico Cozzolino, Ausilia Sellitto, Luca Rinaldi   +3 more
doaj   +1 more source

Sputum immunoglobulin E levels correlate with eosinophilic airway regardless of atopy

Allergy, Asthma & Clinical Immunology
Immunoglobulin E (IgE) is a key molecule that induces mast cell activation in allergic inflammation and contributes to type 2/eosinophilic inflammation in asthmatic airways.
Hyo-In Rhyou, Thi Bich Tra Cao, Quang Luu Quoc, Young-Hee Nam, Hae-Sim Park   +4 more
doaj   +1 more source

A new look at the pathogenesis of asthma

, 2009
Asthma is an inflammatory disorder of the conducting airways that has strong association with allergic sensitization. The disease is characterized by a polarized Th-2 (T-helper-2)-type T-cell response, but in general targeting this component of the ...
Graham C. Roberts, Philipp Thurner, Stephen T. Holgate, Donna E. Davies, Arshad, Hasan S., Howarth, Peter H., Davies, Donna E., Holgate, Stephen T., Roberts, Graham C., Thurner, Philipp J., Hasan S. Arshad, Peter H. Howarth   +11 more
core   +1 more source

Lung maneuvers of large amplitudes for probing physiological alterations in mouse models of asthma

Animal Models and Experimental Medicine, EarlyView.
Lung maneuvers of small amplitudes, such as the ones performed in oscillometry, are the current gold standard to probe lung mechanics in animals, but they are insensitive to detect baseline physiological alterations in mouse models of asthma. Herein, lung maneuvers of different amplitudes were compared in two mouse models of asthma.
Magali Boucher, Cyndi Henry, Marie‐Josée Beaulieu, Andrés Rojas‐Ruiz, Ynuk Bossé   +4 more
wiley   +1 more source

Identification of distinct phenotypes related to benralizumab responsiveness in patients with severe eosinophilic asthma.

PLoS ONE, 2021
PurposeTo characterize the clinical phenotypes of severe eosinophilic asthma based on early responsiveness to benralizumab in terms of forced expiratory volume in 1 second (FEV1) improvement.Patients and methodsSixty-four participants diagnosed with ...
Hideyasu Yamada, Masayuki Nakajima, Masashi Matsuyama, Yuko Morishima, Naoki Arai, Norihito Hida, Taisuke Nakaizumi, Hironori Masuko, Yohei Yatagai, Takefumi Saito, Nobuyuki Hizawa   +10 more
doaj   +1 more source

Prediction of Relapse and Glucocorticoid Dependence in Eosinophilic Granulomatosis With Polyangiitis: Findings From a Large European Cohort

Arthritis &Rheumatology, EarlyView.
Objective Eosinophilic granulomatosis with polyangiitis (EGPA) is a small vessel vasculitis characterized by eosinophilia, asthma, and ear, nose, and throat (ENT) involvement. Although glucocorticoids (GCs) are effective in controlling symptoms, relapses and GC dependence are common. The aim of this study was to develop predictive models for vasculitis
Matthias Papo, Pauline Martinot, Renato A. Sinico, Vítor Silvestre‐Teixeira, Nils Venhoff, Maria‐Letizia Urban, Michele Iudici, Juliane Mahrhold, Francesco Locatelli, Giulia Cassone, Franco Schiavon, Benjamin Seeliger, Thomas Neumann, Claudia Feder, Matthieu Groh, Chiara Marvisi, Maxime Samson, Thomas Barba, David Jayne, Arianna Troilo, Jens Thiel, Bernhard Hellmich, Sara Monti, Carlomaurizio Montecucco, Carlo Salvarani, Jean‐Emmanuel Kahn, Bernard Bonnotte, Cécile‐Audrey Durel, Xavier Puéchal, Luc Mouthon, Loïc Guillevin, Giacomo Emmi, Augusto Vaglio, Raphaël Porcher, Benjamin Terrier, on behalf of the French Vasculitis Study Group and the Eosinophilic Granulomatosis with Polyangiitis European Study Group   +35 more
wiley   +1 more source

Organization, Clinical and Management Indicators on the First Year of Activity of an Outpatient Clinic Dedicated to the Diagnosis and Treatment of Severe Asthma in Italy

Journal of Asthma and Allergy, 2021
Silvia Tognella,1 Claudio Micheletto,2 Alessandro Roggeri,3 Guido Polese,4 Denise Artioli,1 Gianenrico Senna,5 Marco Caminati,5,6 Daniela Paola Roggeri3 1Pulmonology Unit, Mater Salutis Hospital, Legnago (Verona), Italy; 2Pulmonology Unit, Azienda ...
Tognella S, Micheletto C, Roggeri A, Polese G, Artioli D, Senna G, Caminati M, Roggeri DP   +7 more
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