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Eosinophilic and Noneosinophilic Asthma: An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort [PDF]
, 2021 BACKGROUND: Phenotypic characteristics of eosinophilic and non-eosinophilic asthma patients are not well-characterized in global, real life severe asthma cohorts.RESEARCH QUESTION: What is the prevalence of eosinophilic and non-eosinophilic phenotypes in Taube, Christian, Tran, Trung N., Christoff, GC, Popov, TA, Lehtimäki, L, Alan Altraja, Victoria A. Carter, Brusselle, Guy G., Porsbjerg, CM, Costello, RW, Matthew Peters, Bjermer, Leif, Pfeffer, Paul, Jackson, David J, Takashi Iwanaga, Canonica, GW, Al-Ahmad, M, Paul E. Pfeffer, J. Mark FitzGerald, Iwanaga, T, Taillé, C, Busby, J, Carter, Victoria A., Vibeke Backer, Zangrilli, James, Papadopoulos, Nikolaos, FitzGerald, JM, Eleangovan, Neva, Eleangovan, Nevaashni, Tran, Trung N, Bourdin, Arnaud, Arnaud Bourdin, Price, DB, Papaioannou, Andriana, Christoff, George, Brusselle, Guy, Mark Hew, Lehmann, Sverre, Lehtimäki, Lauri, Papaioannou, Andriana I., Alacqua, M, Heaney, Liam G, Iwanaga, Takashi, Tohda, Yuji, Nikos G. Papadopoulos, Christian Taube, Rhee, Chin Kook, John Busby, Mohsen Sadatsafavi, Borja G. Cosio, Popov, Todor, Ruth Murray, Koh, Mariko Siyue, Buhl, Roland, Menzies-Gow, Andrew N, Popov, Todor A, Price, David B, Wang, E, Bulathsinhala, L, Zangrilli, J, Busby, John, Cosio, BG, Papaioannou, AI, Heaney, Liam G., Chaudhry, Isha, Trung N. Tran, Backer, Vibeke, Andriana I. Papaioannou, Camille Taillé, Jackson, David, Price, David B., Hosseini, Naeimeh, Heffler, E, Eleangovan, N, Heffler, Enrico, G. Walter Canonica, Cosio, Borja, Tohda, Y, Kerkhof, Marjan, Kerkhof, M, Papadopoulos, NG, Lakmini Bulathsinhala, Wang, Eileen, Yuji Tohda, Wechsler, ME, Altraja, Alan, Wechsler, Michael E, Luis Perez de Llano, Popov, Todor A., Enrico Heffler, Brusselle, Guy G, Sadatsafavi, M, Leif Bjermer, Pfeffer, Paul E, Chaudhry, I, Mona Al-Ahmad, Tran, Trung, Papadopoulos, Nikolaos G., Celeste M. Porsbjerg, Pfeffer, PE, Menzies-Gow, Andrew N., Murray, RB, Alacqua, Marianna, Siyue, MK, Murray, Ruth, Wechsler, Michael E., Papadopoulos, Nikolaos G, Isha Chaudhry, FitzGerald, J. Mark, Peters, M, Chin Kook Rhee, Price, Chris A., Siyue, Mariko Koh, Pfeffer, Paul E., David B. Price, Chris A. Price, Costello, Richard W, Hosseini, N, George C. Christoff, Altraja, A, Liam G. Heaney, Björnsdóttir, Unnur S, Taillé, Camille, Tran, TN, Lehmann, S, Porsbjerg, Celeste, Buhl, R, Heaney, Liam, Murray, Ruth B., Sadatsafavi, Mohsen, Roland Buhl, Eileen Wang, Christoff, George C., Björnsdóttir, Unnur, Backer, V, Perez de Llano, Luis, David J. Jackson, Mariko Siyue Koh, Christoff, George C, Hew, M, Hew, Mark, Björnsdóttir, Unnur S., Bourdin, A, Jackson, David J., Carter, Victoria, Al-Ahmad, Mona, Andrew N. Menzies-Gow, Porsbjerg, Celeste M., Jackson, DJ, Price, CA, Unnur S. Björnsdóttir, Price, Chris A, Brusselle, GG, Eileen, Wang, Heaney, LG, Naeimeh Hosseini, FitzGerald, J Mark, Canonica, Giorgio Walter, Cosio, Borja G, Marianna Alacqua, James Zangrilli, Cosio, Borja G., Costello, Richard, Menzies-Gow, AN, Costello, Richard W., Richard W. Costello, Papaioannou, Andriana I, Peters, Matthew, G.G.O. (Guy) Brusselle, Menzies-Gow, Andrew, Marjan Kerkhof, Wechsler, Michael, Carter, Victoria A, Murray, Ruth B, Price, Chris, Porsbjerg, Celeste M, Bulathsinhala, Lakmini, Michael E. Wechsler, Sverre Lehmann, Björnsdóttir, US, Lauri Lehtimäki, Bjermer, L, Price, David, Neva Eleangovan, Rhee, CK, Perez de Llano, L, Taube, C, Todor A. Popov, Carter, VA, Kerkhof, Marjan,, Pierachille Santus, Francesco Mazza, Lehmann, Sverre,, Vicente Plaza, Alacqua, Marianna,, Price, Chris A.,, Gianenrico Senna, Francesco Menzella, Paolo Montuschi, Linda Rasmussen, FitzGerald, J. Mark,, Ji yong Moon, Maria D’Amato, Soichiro Hozawa, Tran, Trung N.,, MariaElisabetta Conte, Eleonora Nucera, Pearlanne Zelarney, Murray, Ruth B.,, Désirée Larenas Linnemann, Iwanaga, Takashi,, Johannes Schmid, Bjermer, Leif,, Carlo Lombardi, Hew, Mark,, Salvatore Lo Cicero, Wang, Eileen,, Antonio Spanevello, Riyad Al-Lehebi, Lorenzo Cosmi, Vittorio Viviano, Giovanni Rolla, Manlio Milanese, Takahiko Horiguchi, Cvetanka Odjakova, Girolamo Pelaia, Piotr Kuna, Cristiano Caruso, Papaioannou, Andriana I.,, Menzies-Gow, Andrew N.,, Peters, Matthew,, Heffler, Enrico,, Sadatsafavi, Mohsen,, Stefano Centanni, Jasmina Nurkic, Costello, Richard W.,, Andreanne Cote, Joy Zimmer, Cosio, Borja G.,, Hosseini, Naeimeh,, Mohit Bhutani, Paolo Solidoro, Esther Garcia Gil, Kirsten Rasmussen, Koh, Mariko Siyue,, Giuseppe Spadaro, Gabriella Guarnieri, Eleangovan, Neva,, Pfeffer, Paul E.,, Nunzio Crimi, Hiroshi Tanaka, Cecilia Calabrese, Jae Ha Lee, Backer, Vibeke,, Wechsler, Michael E.,, Nadezda K. Takovska, Giovanni Passalacqua, Ahmed Maher, Laura Pini, Lehtimäki, Lauri,, Gianna Camiciottoli, Karin Dahl Assing, Angelo Guido Corsico, Christoff, George C.,, Price, David B.,, Concetta Sirena, Brusselle, Guy G.,, Dloui Philippe Boulet, Darina Petrova Dimova, Youlim Kim, Lund University., Taube, Christian,, Bassam Mahboub, Kwang Ha Yoo, Luisa Ricciardi, Elisabetta Favero, Al-Ahmad, Mona,, Carter, Victoria A.,, Caterina Bucca, Heaney, Liam G.,, Chaudhry, Isha,, Erminia Ridolo, Ole Hilberg, Konstantinos Kostikas, Canonica, Giorgio Walter,, Papadopoulos, Nikolaos G.,, Alessandro Farsi, Giannis Paraskevopoulos, Plamen Hristov Yakovliev, Maria Teresa Costantino, Charlotte Ulrik, Rupert C. Jones, Sundeep Salvi, Jorge Maspero, Sonya Metodieva Genova, Maria Cristina Zappa, Porsbjerg, Celeste M.,, Roberta Parente, Seung Won Ra, Price Chris A, Anders Christiansen, Luigi Macchia, Diahn-Warng Perng (Steve), Björnsdóttir, Unnur S.,, Zangrilli, James,, Maria Filomena Caiaffa, Taillé, Camille,, Louis Phillipe Boulet, Francesco Blasi, Nicola Scichilone, Carlos A. Torres-Duque, Giuseppe Guida, Buhl, Roland,, Perez de Llano, Luis,, Barbaro Maria Pia Foschino, Diana X. Hristova, Altraja, Alan,, Celine Bergeron, Busby, John,, Marcello Montagni, Pierluigi Paggiaro, Price David B, Kenneth Chapman, Simona D’Alò, Stefano Del Giacco, Bulathsinhala, Lakmini,, Peter G. Gibson, Eleonara M. Stamenova, Stelios Loukides, Daniela Morrone, Violina Milchova Vasileva, Bourdin, Arnaud,, Luca Richeldi, Marco Bonavia, Jackson, David J.,, Andrea Vianello, Fabio Luigi Massimo Ricciardolo, Mona-Rita Yacoub, VincenzoPatella, Katya Vasileva Noleva, Guy G. Brusselle, Nikolaos G. Papadopoulos, Ruth B. Murray, Giorgio Walter Canonica +343 morecore +1 more sourceImpaired macrophage phagocytosis in non-eosinophilic asthma
, 2013 Background Many patients with non-eosinophilic asthma have increased numbers of neutrophils in the airways. The explanation for this chronic inflammation remains unclear, but may result from an impaired ability of alveolar macrophages to phagocytose ...Yang, I., James, A., Reynolds, P. N., Simpson, J. L., AMAZES Study Research Group, Yang, I. A., Upham, J., Simpson, J., Gibson, P. G., Reynolds, P., Gibson, P., AMAZES Study Research Group,, Hodge, S. +12 morecore +1 more sourceCognitive Dysfunction in Chronic Rhinosinusitis: A Scoping Review
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background
Cognitive dysfunction is increasingly recognized as an extra‐nasal manifestation of chronic rhinosinusitis (CRS). This scoping review characterizes the primary evidence on cognition in adult CRS, covering measures, treatment response, and incident dementia.Luke M. O'Neil, Hannan A Qureshi, Logan Lindemann, David J. Cvancara, Ashton E. Lehmann, Aria Jafari +5 morewiley +1 more sourceLonicerin attenuates house dust mite-induced eosinophilic asthma through targeting Src/EGFR signaling
Frontiers in Pharmacology, 2022 Eosinophilic asthma is the predominant phenotype of asthma, and although these patients are sensitive to glucocorticoid therapy, they also experience many side effects.Zhenan Deng, Xuefei Zhang, Junjie Wen, Xiaojing Yang, Lingna Xue, Changxing Ou, Jianjuan Ma, Hongrui Zhan, Xiaomin Cen, Xuliang Cai, Yu Zhang, Riken Chen, Qingling Zhang +12 moredoaj +1 more sourceEfficacy and Predictors of Response to Biologic Therapy and Endoscopic Sinus Surgery in Patients With Nasal Polyps: A Systematic Review
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background
Biologics and endoscopic sinus surgery (ESS) treat refractory chronic rhinosinusitis with nasal polyposis (CRSwNP), but direct comparisons are lacking. We synthesized efficacy and subgroup data across randomized controlled trials (RCTs) of biologics and ESS.Arun Chakravorty, Matthew E. Lin, Rory Lubner, Jess C. Mace, Jeffrey Suh, Jivianne Lee, Marilene Wang, Sarah Wise, Naweed Chowdhury, Zachary M. Soler, Justin Turner, Timothy L. Smith, Myung Sim, Daniel M. Beswick +13 morewiley +1 more sourcePoly(I:C)‐Activated Nasal Fibroblasts Promote Eosinophil Recruitment in CRSwNP
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background
Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by persistent mucosal inflammation and eosinophilic infiltration. Although epithelial and immune cells have been widely studied, the role of nasal fibroblasts in innate immune activation and eosinophil recruitment remains unclear.Chaewon Shin, An‐Gi Kim, Byeong Min Yu, Woo‐Keun Kwon, Min‐Ho Hwang, Joo‐Hoo Park +5 morewiley +1 more sourceAssessing the Mucosal Inflammatory Endotype of Obesity in Chronic Rhinosinusitis
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background
Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory syndrome of the paranasal sinuses that is defined phenotypically as either with nasal polyps (CRSwNP) or without nasal polyps (CRSsNP). More recently, inflammatory markers have been used to cluster patients into putative endotypes that are presumed to have a common ...Jeffanie W. Gayoso, Li‐Ching Huang, Quanhu Sheng, Daniel Lofgren, Ping Li, Katherine Cahill, Mason Krysinski, Rakesh K. Chandra, Justin H. Turner, Naweed Chowdhury +9 morewiley +1 more source
