Results 81 to 90 of about 276,902 (250)

Clinical usefulness of mepolizumab in severe eosinophilic asthma

open access: yes, 2016
Francesco Menzella, Mirco Lusuardi, Gloria Montanari, Carla Galeone, Nicola Facciolongo, Luigi ZucchiDepartment of Cardio-Thoracic-Vascular and Intensive Care Medicine, Pneumology Unit, IRCCS – Arcispedale Santa Maria Nuova, Reggio Emilia ...
Galeone C   +5 more
core  

Effectiveness and safety of mepolizumab in severe refractory eosinophilic asthma: results in clinical practice

open access: yes, 2019
Background: Asthma is an inflammatory disease of the airways with symptoms that vary over time and intensity, sometimes leading to disability or even death. Eosinophilic asthma accounts for 25% of cases of severe asthma.
Olalla Montero-Pérez   +2 more
core   +1 more source

System‐Local Axes and Metabolic Reprogramming From Health to Response in House Dust Mite‐Specific Subcutaneous Immunotherapy for Allergic Rhinitis

open access: yesiMetaMed, EarlyView.
This study delineated nasal‐plasma metabolic reprogramming in house dust mite‐allergic rhinitis (HDM‐AR) and subcutaneous immunotherapy (SCIT) response, showing compartment‐specific signatures dominated by nasal lipid‐redox and plasma nucleotide‐NAD+ axes and across the HC–HDM‐AR–SCIT response continuum, dual‑compartment metabolites exhibited ...
Bixing Fang   +13 more
wiley   +1 more source

Old disease, new twist

open access: yesJournal of Hospital Medicine, EarlyView.
Abstract An 81‐year‐old man with a history of high‐grade urothelial carcinoma of the bladder and ureter on treatment with atezolizumab and tiragolumab presented to the emergency department with 5 months of malaise, generalized weakness, and fatigue and 2 weeks of subjective fevers. One month prior to presentation, he received an empiric 9‐day course of
Hadi Roudsari   +4 more
wiley   +1 more source

Chronic conditions associated with paediatric onset inflammatory bowel diseases: A population‐based study

open access: yesJournal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objective Several conditions are associated with inflammatory bowel disease (IBD), including immune‐mediated inflammatory diseases (IMIDs), extraintestinal manifestations (EIMs), and psychiatric disorders. This study aimed to describe at population‐level the comorbidities and their relative burden in paediatric‐onset IBD (pIBD).
Nicolas Richard   +480 more
wiley   +1 more source

Severe eosinophilic asthma: from the pathogenic role of interleukin-5 to the therapeutic action of mepolizumab

open access: yes, 2017
Corrado Pelaia,1 Alessandro Vatrella,2 Maria Teresa Busceti,1 Luca Gallelli,3 Rosa Terracciano,3 Rocco Savino,3 Girolamo Pelaia1 1Department of Medical and Surgical Sciences, Section of Respiratory Diseases, University “Magna Græcia&rdquo ...
Vatrella A   +6 more
core  

EGF-induced bronchial epithelial cells drive neutrophil chemotactic and anti-apoptotic activity in asthma [PDF]

open access: yes, 2013
Chronic damage and repair of the bronchial epithelium are features of asthma. We have previously reported that ex vivo stimulation of normal bronchial epithelial cells with epidermal growth factor (EGF), a key factor of epithelial repair, enhances the ...
Donna E Davies   +52 more
core   +2 more sources

Type II achalasia unmasked by EndoFLIP and high‐resolution manometry in a child with eosinophilic esophagitis

open access: yesJPGN Reports, EarlyView.
ABSTRACT Eosinophilic esophagitis (EoE) is a chronic immune‐mediated disease characterized by esophageal dysfunction and eosinophilic inflammation. Persistent dysphagia despite histologic remission should prompt evaluation for alternative etiologies. A 10‐year‐old male with asthma and eczema presented with progressive solid food dysphagia, daily non ...
Rasha Abi Radi Abou Jaoudeh   +2 more
wiley   +1 more source

Diagnosis and management of eosinophilic asthma: a US perspective

open access: yesJournal of Asthma and Allergy, 2014
Hannah H Walford,1,2 Taylor A Doherty11Department of Medicine, 2Department of Pediatrics, University of California, La Jolla, CA, USAAbstract: Eosinophilic asthma is now recognized as an important subphenotype of asthma based on the pattern of ...
Walford HH, Doherty TA
doaj  

Eosinophil Peroxidase Activity is a Reliable and Resilient Biomarker for Eosinophilic Chronic Rhinosinusitis

open access: yes
International Forum of Allergy &Rhinology, EarlyView.
Christian Caceres   +14 more
wiley   +1 more source

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