Results 71 to 80 of about 51,921 (307)
The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma [PDF]
, 2016 Chronic asthma is associated with persistent lung inflammation and long-term remodelling of the airways that have proved refractory to conventional treatments such as steroids, despite their efficacy in controlling acute airway contraction and bronchial ...
Al-Riyami, L. +6 more
core +1 more source
Eosinophilic bioactivities in severe asthma [PDF]
World Allergy Organization Journal, 2016 Asthma is clearly related to airway or blood eosinophilia, and asthmatics with significant eosinophilia are at higher risk for more severe disease. Eosinophils actively contribute to innate and adaptive immune responses and inflammatory cascades through the production and release of diverse chemokines, cytokines, lipid mediators and other growth ...
Carr, Tara F +4 more
openaire +4 more sources
Dupilumab Beyond the Airway: Decreased Morbidity in a Real‐World Analysis
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Post hoc analyses of clinical trials have characterized dupilumab's adverse effects, yet the real‐world impact in chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma is not well described. This study aims to characterize the risks of lymphoma, cardiovascular events, eosinophilia, joint pain, inflammatory arthritis, and ...
Emma J. Anisman +9 more
wiley +1 more source
Eosinophilic Digestive Disease (EDD) and Allergic Bronchial Asthma; Two Diseases or Expression of One Disease in Two Systems? [PDF]
, 2011 Eosinophilic digestive disease (EDD) includes a broad spectrum of clinical presentations due to eosinophilic inflammation involving anywhere from the esophagus to the rectum.
Yakoot Mostafa
core +2 more sources
Frontiers in Pharmacology, 2022 Eosinophilic asthma is the predominant phenotype of asthma, and although these patients are sensitive to glucocorticoid therapy, they also experience many side effects.
Zhenan Deng +12 more
doaj +1 more source
Mepolizumab in refractory eosinophilic asthma [PDF]
Thorax, 2010 In a recent Lung Alert reviewing our study of mepolizumab in severe eosinophilic asthma,1 Barratt states that the study population represented a minority of patients with asthma and that they had corticosteroid-resistant disease.2 These comments require clarification.
Pavord, ID +3 more
openaire +3 more sources
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background The indication for nasal irrigation with corticosteroids after sinus surgery in patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is well established, as surgery facilitates distribution throughout the sinonasal cavity.
Juliana Sant'Ana +5 more
wiley +1 more source
Inflammatory Airway Disease of Horses - Revised Consensus Statement [PDF]
, 2016 The purpose of this manuscript is to revise and update the previous consensus statement on inflammatory airway disease (IAD) in horses. Since 2007, a large number of scientific articles have been published on the topic and these new findings have led to ...
Cardwell, J M +5 more
core +4 more sources
Rationale of New Grading System: Central Compartment Atopic Disease
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Central compartment atopic disease (CCAD) has recently been recognized as a distinct phenotype within the spectrum of type 2–dominant chronic rhinosinusitis (CRS). Although international guidelines highlight polypoid changes in the central nasal cavity, standardized diagnostic and classification criteria are still lacking.
Ramón Moreno‐Luna +11 more
wiley +1 more source
Type 2 Innate Lymphoid Cells in Allergic Disease. [PDF]
, 2013 Type II innate lymphoid cells (ILC2) are a novel population of lineage-negative cells that produce high levels of Th2 cytokines IL-5 and IL-13. ILC2 are found in human respiratory and gastrointestinal tissue as well as in skin.
Doherty, Taylor A +2 more
core +2 more sources