Results 31 to 40 of about 23,640 (262)

May mepolizumab used in asthma correct subfertility?

Annals of Medicine, 2021
İntroduction Asthma is one of the most common chronic airway disease among reproductive period of women. Chronic inflammation in asthma, eosinophilia, high steroid treatment and uncontrolled asthma may cause infertility by affecting the reproductive ...
Guzin Ozden, Pelin Pınar Deniz
doaj   +1 more source

Sputum Hyaluronan and Versican in Severe Eosinophilic Asthma [PDF]

International Archives of Allergy and Immunology, 2012
<b><i>Background:</i></b> We examined levels of hyaluronan, a matrix glycosaminoglycan and versican, a matrix proteoglycan, in the sputum of asthmatics treated with mepolizumab (anti-IL-5 monoclonal antibody) versus placebo to evaluate the utility of these measurements as possible biomarkers of asthma control and airway ...
Andrew G, Ayars, Leonard C, Altman, Sue, Potter-Perigo, Katherine, Radford, Thomas N, Wight, Parameswaran, Nair   +5 more
openaire   +2 more sources

Organization, Clinical and Management Indicators on the First Year of Activity of an Outpatient Clinic Dedicated to the Diagnosis and Treatment of Severe Asthma in Italy

Journal of Asthma and Allergy, 2021
Silvia Tognella,1 Claudio Micheletto,2 Alessandro Roggeri,3 Guido Polese,4 Denise Artioli,1 Gianenrico Senna,5 Marco Caminati,5,6 Daniela Paola Roggeri3 1Pulmonology Unit, Mater Salutis Hospital, Legnago (Verona), Italy; 2Pulmonology Unit, Azienda ...
Tognella S, Micheletto C, Roggeri A, Polese G, Artioli D, Senna G, Caminati M, Roggeri DP   +7 more
doaj  

Case Report: Severe Eosinophilic Asthma Associated With ANCA-Negative EGPA in a Young Adult Successfully Treated With Benralizumab

Frontiers in Pharmacology, 2022
Background: Traditionally, Eosinophilic Granulomatosis with Polyangiitis (EGPA) has been treated with systemic corticosteroids and immunosuppressants. In recent years, therapeutic efforts have been directed towards targeting eosinophils which represent a
Luisa Ricciardi, Daniel Griscti Soler, Alessandra Bennici, Silvia Brunetto, Giovanni Pioggia, Sebastiano Gangemi   +5 more
doaj   +1 more source

Distinct functions of eosinophils in severe asthma with type 2 phenotype: clinical implications [PDF]

The Korean Journal of Internal Medicine, 2020
Asthma is commonly recognized as a heterogeneous condition with a complex pathophysiology. With advances in the development of multiple medications for patients with asthma, most asthma symptoms are well managed.
Youngwoo Choi, Soyoon Sim, Hae-Sim Park
doaj   +1 more source

Remission outcomes in severe eosinophilic asthma with mepolizumab therapy: Analysis of the REDES study

Frontiers in Immunology, 2023
IntroductionClinical remission as a multicomponent treatment goal in severe asthma is being explored in clinical practice. This post hoc analysis used data from the REDES study to assess the proportion of patients with severe eosinophilic asthma ...
Ian Pavord, Frances Gardiner, Liam G. Heaney, Christian Domingo, Robert G. Price, Alison Pullan, John Oppenheimer, Guy Brusselle, Hiroyuki Nagase, Geoffrey Chupp, Emilio Pizzichini, Emilio Pizzichini, David Bañas-Conejero, Peter Howarth   +13 more
doaj   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Assessing the Anti-Inflammatory Effects of an Orally Dosed Enzymatically Liberated Fish Oil in a House Dust Model of Allergic Asthma

Biomedicines, 2022
Eosinophils are a major driver of inflammation in a number of human diseases, including asthma. Biologic therapies targeting IL-5 have enabled better control of severe eosinophilic asthma, but no such advances have been made for enhancing the control of ...
Crawford Currie, Bomi Framroze, Dave Singh, Simon Lea, Christian Bjerknes, Erland Hermansen   +5 more
doaj   +1 more source

Sputum autoantibodies in patients with severe eosinophilic asthma [PDF]

Journal of Allergy and Clinical Immunology, 2018
The persistence of eosinophils in sputum despite high doses of corticosteroids indicates disease severity in asthmatic patients. Chronic inflamed airways can lose tolerance over time to immunogenic entities released on frequent eosinophil degranulation, which further contributes to disease severity and necessitates an increase in maintenance ...
Manali, Mukherjee, David C, Bulir, Katherine, Radford, Melanie, Kjarsgaard, Chynna Margaret, Huang, Elizabeth A, Jacobsen, Sergei I, Ochkur, Ana, Catuneanu, Hanah, Lamothe-Kipnes, James, Mahony, James J, Lee, Paige, Lacy, Parameswaran K, Nair   +12 more
openaire   +2 more sources

Allergic Rhinitis Amplifies Asthma Risk in Patients With Chronic Rhinosinusitis: A Large‐Scale Retrospective Cohort Analysis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) are two highly prevalent airway diseases in the United States. While the coexistence of CRS and asthma is well recognized, less is known about the development of new‐onset asthma in CRS, particularly in the context of comorbid AR. This study assessed the impact of CRS and AR on
Austin J. Lee, Mohamad R. Chaaban
wiley   +1 more source