Results 21 to 30 of about 2,200,340 (304)

Application of an algorithm to analyze patterns of intermittent oral corticosteroid use in asthma

npj Primary Care Respiratory Medicine, 2023
An algorithm to describe patterns of intermittent oral corticosteroid use in the UK (n = 476,167) found that one-third of patients receiving intermittent oral corticosteroids for asthma only had short gaps (
John Haughney, Trung N. Tran, Heath Heatley, Arnaud Bourdin, Andrew Menzies-Gow, David J. Jackson, Ekaterina Maslova, Jatin Chapaneri, Derek Skinner, Victoria Carter, Jeffrey Shi Kai Chan, David Price   +11 more
doaj   +1 more source

Real-world study in severe eosinophilic asthma patients refractory to anti-IL5 biological agents treated with benralizumab in Spain (ORBE study)

BMC Pulmonary Medicine, 2021
Background Benralizumab, a monoclonal antibody targeting the human interleukin-5 (IL-5) receptor (IL-5R), was used before marketing authorisation in Spain in a real world setting as part of an early-access programme (EAP) to treat patients with severe ...
Eva Martínez-Moragón, Ismael García-Moguel, Javier Nuevo, Gustavo Resler, ORBE study investigators   +4 more
doaj   +1 more source

Depiction of Major Mite Allergens in Severe Allergic Rhinitis with High Mite Perennial Exposure

Turkish Archives of Otorhinolaryngology, 2020
Objective: Airway diseases, including allergic rhinitis, are prompted by specific IgE antibodies against airborne allergens and notably those derived from mites.
Ruperto González-Pérez, Paloma Poza-Guedes, Fernando Pineda, Miriam Castillo   +3 more
doaj   +1 more source

Problematic severe asthma in children, not one problem but many: a GA(2)LEN initiative

, 2010
Although most children with asthma are easy to treat with low doses of safe medications, many remain symptomatic despite every therapeutic effort.
Hedlin G, Lødrup Carlsen K, PERONI, Diego, Problematic Severe Asthma in Childhood Initiative group, Bush A   +4 more
core   +2 more sources

Biologics and global burden of asthma: A worldwide portrait and a call for action

World Allergy Organization Journal, 2021
Biologics for severe asthma can significantly impact on the burden of disease and also have the potential to reduce asthma mortality. By reviewing the literature and contacting the pharmaceutical companies, the present paper aims at providing a worldwide
M. Caminati, M. Morais-Almeida, E. Bleecker, I. Ansotegui, G.W. Canonica, C. Bovo, G. Senna   +6 more
doaj   +1 more source

CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development [PDF]

, 2016
Single nucleotide polymorphisms (SNPs) in chitinase 3-like 1 (CHI3L1), the gene encoding YKL-40, and increased serum YKL-40 levels are associated with severe forms of asthma. It has never been addressed whether SNPs in CHI3L1 and cord blood YKL-40 levels
Gorlanova, Olga, Olga Gorlanova, Latzin, Philipp, Frey, Urs, Jakob Usemann, Urs Frey, Philipp Latzin, Dominik Hartl, Mack, Ines, Hartl, Dominik, Schmidt, Anne, Röösli, Martin, Ines Mack, Usemann, Jakob, Martin Röösli, Anne Schmidt, Latzin P, Usemann J, Schmidt A, Röösli M, Mack I, Hartl D, Gorlanova O, Frey U   +23 more
core   +2 more sources

Critical evaluation of asthma biomarkers in clinical practice

Frontiers in Medicine, 2022
The advent of personalized medicine has revolutionized the whole approach to the management of asthma, representing the essential basis for future developments.
Giuseppe Guida, Diego Bagnasco, Vitina Carriero, Francesca Bertolini, Fabio Luigi Massimo Ricciardolo, Stefania Nicola, Luisa Brussino, Emanuele Nappi, Emanuele Nappi, Giovanni Paoletti, Giovanni Paoletti, Giorgio Walter Canonica, Giorgio Walter Canonica, Enrico Heffler, Enrico Heffler   +14 more
doaj   +1 more source

EGF-induced bronchial epithelial cells drive neutrophil chemotactic and anti-apoptotic activity in asthma [PDF]

, 2013
Chronic damage and repair of the bronchial epithelium are features of asthma. We have previously reported that ex vivo stimulation of normal bronchial epithelial cells with epidermal growth factor (EGF), a key factor of epithelial repair, enhances the ...
Donna E Davies, Cornelius Victoria, Grégory Seumois, Lau, LC, Karl J Staples, Cornelius, Victoria, Dorinsky, P, Victoria Cornelius, Davies Donna E., Dinesh Bagmane (457229), Staples, Karl J., Uddin, Mohib, Ratko Djukanović, Pandurangan Vijayanand, Victoria Cornelius (457230), Lau, Laurie C., Mohib Uddin (457226), Karl J. Staples (457228), Bagmane, Dinesh, Ratko Djukanović (457232), Paul Dorinsky, Pandurangan Vijayanand (277869), Djukanović Ratko, Lau, Laurie C, Grégory Seumois (5656213), Lau Laurie C., Staples, KJ, Vijayanand, P, Vijayanand, Pandurangan, Laurie C. Lau (457227), Seumois, G, Uddin, M, Staples, Karl J, Davies, Donna E, Staples Karl J., Davies, DE, Donna E. Davies (137702), Seumois Grégory, Djukanović, R, Dinesh Bagmane, Djukanović, Ratko, Cornelius, V, Davies, Donna E., Laurie C Lau, Dorinsky Paul, Paul Dorinsky (457231), Dorinsky, Paul, Seumois, Grégory, Bagmane Dinesh, Uddin Mohib, Bagmane, D, Mohib Uddin, Vijayanand Pandurangan   +52 more
core   +2 more sources

Pharmacotherapy of severe asthma [PDF]

Current Opinion in Pharmacology, 2010
Severe asthma is a complex and heterogeneous phenotype where management can be challenging. While many patients with severe asthma respond to high-dose inhaled corticosteroids in combination with a long-acting beta-agonist, there remains a significant subset of patients that require oral corticosteroids to control symptoms.
Rafael, Firszt, Monica, Kraft
openaire   +2 more sources

Is Bronchiectasis (BE) Properly Investigated in Patients with Severe Asthma? A Real-Life Report from Eight Italian Centers

Journal of Respiration, 2023
Introduction: Asthma and bronchiectasis are often partners in a complex but uneven relationship with asthma receiving more attention. The aim of this study is to describe how bronchiectasis is investigated in some Severe Asthma (SA) Centers, scattered ...
Giovanna Elisiana Carpagnano, Vitaliano Nicola Quaranta, Claudia Crimi, Pierachille Santus, Francesco Menzella, Corrado Pelaia, Giulia Scioscia, Cristiano Caruso, Elena Bargagli, Nicola Scichilone, Eva Polverino   +10 more
doaj   +1 more source