Results 41 to 50 of about 2,200,340 (304)

Small Airways Disease Adversely Impacts the Response to Biologic Therapies in Severe Asthma

Pulmonary Therapy
Introduction Small airways disease (SAD) is increasingly recognized as a relevant trait in severe asthma, but its influence on outcomes with biologic therapies remains uncertain.
Chiara Allegrini, Elisa Bentivegna, Alessia Catalisano, Greta Insalata, Rubina Giulia Girolamo, Martina Maria Marinato, Luca Paita, Alessandra Sorano, Chiara Marzi, Clara De Filippis, Federico Lavorini, Gianna Camiciottoli   +11 more
doaj   +1 more source

Asthma control in severe asthma and occupational exposures to inhalable asthmagens

BMJ Open Respiratory Research
Introduction Work-related asthma accounts for ≥25% of asthma in working-age populations, though the relationship between work exposures and symptoms is frequently missed, leading to poor health and employment outcomes.
Mamidipudi Thirumala Krishna, Adel H Mansur, Gareth I Walters, Nicole Le Moual, Christopher C Huntley, Julie Marsh, Christopher Reilly, Hanan Hussein, Ali Bahron   +8 more
doaj   +1 more source

Attack, Flare-up or Exacerbation? The terminology preferences of patients with severe asthma

, 2019
Background: People with severe asthma experience frequent life-threatening acute asthma events. A Lancet commission recently highlighted that terms ‘exacerbations’ and ‘flare-ups’ are seen to trivialise these episodes and recommended use of the term ...
McDonald, Vanessa, Jones, Kimberley, Smith, Amber, Gibson, Peter, Yorke, Janelle, Niven, Robert, Gibson, PG, Smith, A, Jones, KA, McDonald, VM, Niven, R   +10 more
core   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Factors Associated With the Rising Trend in Self‐Reported Cognitive Disability Among U.S. Adults Aged 18–39 From 2013–2024

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Building on our prior Behavioral Risk Factor Surveillance System analysis identifying adults aged 18–39 as the primary driver of the national increase in self‐reported cognitive disability, we examined factors associated with this rise using 2013–2024 U.S. BRFSS data. Methods We analyzed U.S.
Adam de Havenon, Ka‐Ho Wong, Mirriam Mananah, Christopher D. Anderson, Ada Fenick, Amy Arnsten, Arman Fesharaki‐Zadeh, James C. McPartland, Mary L. Adams, Kevin N. Sheth   +9 more
wiley   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

The asthma-obstructive sleep apnea overlap: pathophysiological links, clinical impact, and implications for integrated management [PDF]

Exploration of Asthma & Allergy
The asthma-obstructive sleep apnea (OSA) overlap is a clinically important phenotype, especially in patients with severe or difficult-to-control asthma.
Carlo Lombardi, Marcello Cottini, Francesco Menzella   +2 more
doaj   +1 more source

Health Care Use Among Patients Presenting to Emergency Department for Gout Flares in Ontario, Canada: A Population‐Based Health Systems Analysis

Arthritis Care &Research, EarlyView.
Objective We characterized emergency department (ED) gout visits and identified patient characteristics and health services patterns contributing to ED presentations. Methods We conducted a population‐based study of ED gout visits in Ontario, Canada, between 2014 and 2023.
Timothy S. H. Kwok, Samantha Morais, William K. Silverstein, Clare L. Atzema, Gregory Choy, Priyanka Chandratre, Ping Li, Jessica Widdifield   +7 more
wiley   +1 more source

The illness burden of severe asthma contrasted to people with mild-to-moderate asthma: a qualitative study

ERJ Open Research
Background Disabling symptoms of asthma including breathlessness, cough, wheeze and chest tightness largely impact quality of life; however, how these symptoms impact people with asthma of different severity levels remains unknown.
Eleanor C. Majellano, Janelle Yorke, Vanessa L. Clark, Peter G. Gibson, Amber J. Smith, Leanne J. Holmes, Vanessa M. McDonald   +6 more
doaj   +1 more source

The Gut–Heart Axis in Systemic Sclerosis: Evidence From a Large Prospective Early Disease Cohort

Arthritis Care &Research, EarlyView.
Objective Cardiac involvement significantly impacts prognosis in systemic sclerosis (SSc), highlighting the need for early risk stratification. Gastrointestinal (GI) symptoms are common and often manifest early. Emerging data suggest a link between GI and cardiac manifestations, possibly through shared mechanisms like dysautonomia.
Francesca R. Di Ciommo, Ashish P. Balar, Aidan K. Strother, Subhash Kulkarni, Michael Hughes, Brian Skaug, Maureen D. Mayes, Shervin Assassi, Ali Y. Ayla, Zsuzsanna H. McMahan   +9 more
wiley   +1 more source